Top 100 Key Players companies in Lysosome by Highest Patent Value in the world in 2019 – Discovery

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The Lysosome top 100 is Discovery PatSnap’ annual ranking of the top 100 Highest Patent Value Lysosome Key Players in the world. Discovery has identified the top key players, startups & unicorns, fast-growings, news entrants in 2019, ranking from differnt perspectives, including patent filing intensity, academic research capability, news media heat. The company list is generated from various data types.

A lysosome (/ˈlaɪsəˌsoʊm/) is a membrane-bound organelle found in many animal cells. They are spherical vesicles that contain hydrolytic enzymes that can break down many kinds of biomolecules. A lysosome has a specific composition, of both its membrane proteins, and its lumenal proteins. The lumen's pH (~4.5–5.0) is optimal for the enzymes involved in hydrolysis, analogous to the activity of the stomach. Besides degradation of polymers, the lysosome is involved in various cell processes, including secretion, plasma membrane repair, cell signaling, and energy metabolism.

1	Synageva BioPharma Corp.	Massachusetts, United States	Botanical drug,Herb,Accelerated atherosclerosis, ...[+2]	Avg patent value: 8.58 M
2	Regents of the University of California	California, United States	Working capital,Pathology,Companion diagnostic, ...[+2]	Avg patent value: 8.50 M
3	Vertex Pharmaceuticals, Inc.	Massachusetts, United States	Health care,Medicine,Cystic fibrosis, ...[+2]	Avg patent value: 8.04 M
4	Alexion Pharmaceuticals, Inc.	Connecticut, United States	Health care,Biopharmaceutical,Clinical trial, ...[+2]	Avg patent value: 7.96 M
5	Shire Human Genetic Therapies, Inc.	Massachusetts, United States	Medicine	Avg patent value: 7.38 M
6	Medigene Immunotherapies GmbH	Germany	Immunotherapy,Cell therapy,Medicine, ...[+2]	Avg patent value: 6.11 M
7	Seagen Inc.	Washington, United States	Antibody-drug conjugate,Medicine,Health care, ...[+2]	Avg patent value: 5.94 M
8	Wellstat Therapeutics Corp.	United States	Drug discovery,Pharmacy,Drug development, ...[+2]	Avg patent value: 5.74 M
9	Zymenex A/S	Hovedstaden, Denmark	Clinical trial,Pharmacy and Therapeutics,Medicine, ...[+2]	Avg patent value: 5.70 M
10	Sangamo Therapeutics, Inc.	California, United States	Cell,Pharmacy and Therapeutics,Genomics, ...[+2]	Avg patent value: 5.61 M
11	BioMarin Pharmaceutical, Inc.	California, United States	Software development,Biopharmaceutical,Clinical trial, ...[+2]	Avg patent value: 5.44 M
12	Immunomic Therapeutics, Inc.	Pennsylvania, United States	Biology,Medicine,Pharmacy and Therapeutics, ...[+2]	Avg patent value: 4.79 M
13	MedImmune Ltd.	Cambridgeshire, United Kingdom	Molecular engineering,Medicine	Avg patent value: 4.74 M
14	Precigen, Inc.	United States	Cell therapy,Biology,Health care, ...[+2]	Avg patent value: 4.44 M
15	Riptide Bioscience, Inc.	United States	Colitis,Organism,Human body, ...[+2]	Avg patent value: 4.38 M
16	Genzyme Corp.	Massachusetts, United States	Medicine,Pharmacy and Therapeutics,Multiple sclerosis, ...[+2]	Avg patent value: 4.35 M
17	Genmab A/S	Hovedstaden, Denmark	Health care,Antibody,Biotechnology, ...[+2]	Avg patent value: 4.21 M
18	Genmab BV	Netherlands		Avg patent value: 4.21 M
19	Protalix Ltd.	Haifa, Israel		Avg patent value: 4.05 M
20	Celsion Corp.	New Jersey, United States	Immunotherapy,Pharmacy and Therapeutics,Health care, ...[+2]	Avg patent value: 3.95 M
21	BCN Peptides SA	Cataluña, Spain	Peptide,Chemical engineering,Retinopathy, ...[+2]	Avg patent value: 3.77 M
22	Genentech, Inc.	California, United States	Biotechnology,Biology,Medicine, ...[+2]	Avg patent value: 3.76 M
23	PCI Biotech AS	Akershus, Norway	Vaccination,Bile duct cancer,Cancer vaccine, ...[+2]	Avg patent value: 3.76 M
24	Inatherys SAS	France	Health care,Monoclonal antibody,Cancer, ...[+1]	Avg patent value: 3.74 M
25	Bayer HealthCare AG	Nordrhein-Westfalen, Germany	Health care,Diabetes Therapy,Immunoprotein, ...[+2]	Avg patent value: 3.60 M
26	Bayer Healthcare LLC	New Jersey, United States	Pharmaceutical medicine,Medicine,Computed tomography, ...[+2]	Avg patent value: 3.60 M
27	Vakzine Projekt Management GmbH	Niedersachsen, Germany	Small molecule,Medicine,Drug development, ...[+2]	Avg patent value: 3.34 M
28	Bristol-Myers Squibb FCT bêta, Inc.	Texas, United States	Health care,Biological pathway,Biopharmaceutical, ...[+2]	Avg patent value: 3.15 M
29	STARTUP Inflectis Bioscience SAS	Pays de la Loire, France	Medicine,Health care,Proteostasis, ...[+2]	Avg patent value: 3.07 M
30	biOasis Technologies, Inc.	British Columbia, Canada	Biopharmaceutical,Brain cancers,Biomedicine, ...[+2]	Avg patent value: 2.95 M
31	UbiVac, Inc.	Oregon, United States	Immunotherapy,Medicine,Wellness Programs, ...[+2]	Avg patent value: 2.77 M
32	Orphazyme A/S	Hovedstaden, Denmark	Lysosomal storage disease,Medicine,Pharmacy and Therapeutics, ...[+2]	Avg patent value: 2.77 M
33	Eleva GmbH	Baden-Württemberg, Germany	Fabry's disease,Therapeutic protein,Technology transfer, ...[+2]	Avg patent value: 2.58 M
34	Amicus Therapeutics, Inc.	New Jersey, United States	Pharmacological chaperone,Medicine,Health care, ...[+2]	Avg patent value: 2.52 M
35	Sarepta Therapeutics, Inc.	Massachusetts, United States	Pharmacy and Therapeutics,Health care,Approved drug, ...[+2]	Avg patent value: 2.37 M
36	Nanjing Mingde New Drug Research and Development Co., Ltd.			Avg patent value: 2.30 M
37	STARTUP IntraBio Ltd.	Oxfordshire, United Kingdom	Clinical trial,Medicine,Drug, ...[+2]	Avg patent value: 2.01 M
38	Esteve Pharmaceuticals S.A.	Cataluña, Spain	Ophthalmology,Pathology,Pharmacy, ...[+2]	Avg patent value: 1.95 M
39	ESTEVE	Cataluña, Spain	Drug,Medicine,Health care, ...[+2]	Avg patent value: 1.95 M
40	Sanofi	Île-de-France, France	Health care,Pharmacy and Therapeutics,Drug, ...[+2]	Avg patent value: 1.85 M
41	biOasis Advanced Technologies, Inc.	CA		Avg patent value: 1.85 M
42	Centogene AG	Mecklenburg-Vorpommern, Germany	Clinical trial,Health care,Genetic analysis, ...[+2]	Avg patent value: 1.81 M
43	PerkinElmer Health Sciences, Inc.	MA, US	Medicine	Avg patent value: 1.75 M
44	DuPont Nutrition Biosciences ApS	Hovedstaden, Denmark	Food science,Medicine,Health care, ...[+2]	Avg patent value: 1.66 M
45	Massachusetts General Hospital	Massachusetts, United States	Substance abuse,Hospitality industry,Health care, ...[+2]	Avg patent value: 1.63 M
46	The General Hospital Corp.	Massachusetts, United States	Health care,Hospitality industry,Vascular Medicine, ...[+2]	Avg patent value: 1.63 M
47	REGENXBIO, Inc.	United States	Gene delivery,Viral vector,Pharmacy and Therapeutics, ...[+2]	Avg patent value: 1.53 M
48	University of Washington Center for Commercialization	WA, US		Avg patent value: 1.46 M
49	PerkinElmer Life Sciences, Inc.	MA, US	Drug discovery,Botanical drug,Herb, ...[+2]	Avg patent value: 1.46 M
50	UCL Business Ltd.	United Kingdom	Intellectual property,Lampalizumab,Angiogenesis inhibitor, ...[+2]	Avg patent value: 1.28 M
51	Nihon Shokuhin Kako Co., Ltd.	Tokyo, Japan	Starch,Food industry,Food processing, ...[+2]	Avg patent value: 1.27 M
52	Takeda Pharmaceutical Co., Ltd.	Osaka, Japan	Medicine,Health care,Clinical trial, ...[+2]	Avg patent value: 1.22 M
53	Takeda Chemical Industries Ltd.	Japan	Pharmaceutical drug,Botanical drug,Herb	Avg patent value: 1.22 M
54	ArmaGen, Inc.	California, United States	Health care,Iduronidase,Mucopolysaccharidosis, ...[+2]	Avg patent value: 1.07 M
55	FUJIFILM Corp.	Tokyo, Japan	Photography,Medical imaging,Computer hardware, ...[+2]	Avg patent value: 943,500
56	Protec Co., Ltd.	South Korea	Semiconductor,Pneumatic cylinder,Electronic component, ...[+1]	Avg patent value: 920,000
57	Marker Gene Technologies, Inc.	Oregon, United States	Biotechnology,Microarray,Marker gene, ...[+2]	Avg patent value: 905,857
58	Rexahn Pharmaceuticals, Inc.	United States	Medicine,Medical equipment,Drug, ...[+2]	Avg patent value: 870,000
59	Ocuphire Pharma, Inc.	Michigan, United States	OPHTHALMIC DISORDERS,Glaucoma,Eye drop, ...[+2]	Avg patent value: 870,000
60	CHIESI Farmaceutici SpA	Emilia-Romagna, Italy	Inhaler,Neonatology,Medicine, ...[+2]	Avg patent value: 863,428
61	Maco Pharma SAS	France	Medical equipment,Medicine	Avg patent value: 860,000
62	ChemGenes Corp.	Massachusetts, United States	Health care,RNA,DNA, ...[+2]	Avg patent value: 830,000
63	Regeneron Pharmaceuticals, Inc.	New York, United States	Monoclonal antibody,Clinical trial,Cholesterol, ...[+2]	Avg patent value: 800,624
64	Arrogene, Inc.	California, United States	Cancer,Medicine,Drug	Avg patent value: 760,000
65	Arrogene	California, United States	Glioma,Pre-clinical development,Cancer	Avg patent value: 760,000
66	Femtobiomed, Inc.	Kyonggi-do, South Korea	Cell therapy,Medicine	Avg patent value: 570,000
67	Femto Bio Med, Inc.	Gyeonggi-do, South Korea	Medicine	Avg patent value: 570,000
68	Dojindo Laboratories	Japan		Avg patent value: 500,000
69	Valerion Therapeutics LLC	Massachusetts, United States	Medicine,Pharmacy and Therapeutics,Alglucosidase alfa, ...[+2]	Avg patent value: 430,000
70	Seikagaku Corp.	Tokyo, Japan	Viscosupplementation,Health care,SURGICAL AIDS, ...[+2]	Avg patent value: 257,666
71	Fondazione Telethon	Lombardia, Italy	Gene delivery,Cell therapy,Plasmid, ...[+2]	Avg patent value: 200,000
72	STARTUP Ligandal, Inc.	New York, United States	CRISPR,Coronavirus disease 2019 (COVID-19),Cell therapy, ...[+2]	Avg patent value: 160,000
73	Merck & Co., Inc.	New Jersey, United States	Health care,Biopharmaceutical,Drug, ...[+2]	Avg patent value: 150,000
74	Merck Sharp & Dohme Corp.	New Jersey, United States	Prescription drug,Medicine,Stroke, ...[+2]	Avg patent value: 150,000
75	Ambrx, Inc.	California, United States	Biology,Pharmacy and Therapeutics,Dosing Frequency, ...[+2]	Avg patent value: 150,000
76	ERYTech Pharma SA	Rhône-Alpes, France	Medicine,Health care,Hematology, ...[+2]	Avg patent value: 140,000
77	STARTUP Prevail Therapeutics, Inc.	New York, United States	Gene,Health care,Pharmacy and Therapeutics, ...[+2]	Avg patent value: 139,638
78	Minoryx Therapeutics SL	Cataluña, Spain	Medicine,Health care,Adrenoleukodystrophy, ...[+2]	Avg patent value: 130,000
79	JCR Pharmaceuticals Co., Ltd.	Hokkaido, Japan	Raw material,Drug,Medicine, ...[+2]	Avg patent value: 123,774
80	National University Corp. Tokyo Medical & Dental University	Japan		Avg patent value: 120,000
81	Synpac (North Carolina), Inc.	North Carolina, United States		Avg patent value: 88,000
82	Denali Therapeutics, Inc.	California, United States	Biotechnology,Pharmacy and Therapeutics,Biological process, ...[+2]	Avg patent value: 87,625
83	STARTUP NEUWAY Pharma GmbH	Nordrhein-Westfalen, Germany	Health care,Progressive multifocal leukoencephalopathy,Metachromatic leukodystrophy, ...[+2]	Avg patent value: 79,580
84	Haode Technology Co., Ltd.	Shanghai Shi, China	Construction engineering	Avg patent value: 70,000
85	Ningbo Kunpeng Biotech Co., Ltd.	China		Avg patent value: 67,000
86	Biographene Co., Ltd.	GY, KR	Electronics	Avg patent value: 66,000
87	Astellas Pharma, Inc.	Tokyo, Japan	Health care,Clinical trial,Diabetic complication, ...[+2]	Avg patent value: 65,488
88	Swedish Orphan Biovitrum AB	Sweden	Medicine,Clinical trial,Biotechnology, ...[+2]	Avg patent value: 60,000
89	iNtRON Biotechnology, Inc.	South Korea	Antibiotics,Medicine,Molecular diagnostics, ...[+2]	Avg patent value: 59,000
90	STARTUP Evox Therapeutics Ltd.	Oxfordshire, United Kingdom	Exosome,Health care,Genomics, ...[+2]	Avg patent value: 58,000
91	Bayer AG	Nordrhein-Westfalen, Germany	Health care,Biology,Chemical engineering, ...[+2]	Avg patent value: 48,000
92	Bayer Pharma AG	Berlin, Germany	Medicine,Nuclear medicine,Andrology, ...[+2]	Avg patent value: 48,000
93	Bayer Oy	Finland		Avg patent value: 48,000
94	CJ CheilJedang Corp.	South Korea	Sugar,Food processing,Food industry, ...[+2]	Avg patent value: 47,000
95	KemPharm Denmark A/S	Capital, Denmark	Central nervous system,Chemistry,Biology, ...[+2]	Avg patent value: 46,000
96	STARTUP Astellas Gene Therapies, Inc.	California, United States	Health care,Gene,Biotechnology, ...[+2]	Avg patent value: 39,000
97	Orbis Health Solutions LLC	South Carolina, United States	Health care	Avg patent value: 38,000
98	Ospedale San Raffaele Srl	Lombardia, Italy	Pathology,Health care,Hospitality industry, ...[+2]	Avg patent value: 37,500
99	SFC Co., Ltd.	Chungcheongbuk-do, South Korea	Electronics,Semiconductor,Electronic component	Avg patent value: 36,000
100	Korea University Reserch & Business Foundation	South Korea		Avg patent value: 36,000