Top 100 Key Players companies in Lysosome by Most Patent Citation in the world in 2018 – Discovery

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The Lysosome top 100 is Discovery PatSnap’ annual ranking of the top 100 Most Patent Citation Lysosome Key Players in the world. Discovery has identified the top key players, startups & unicorns, fast-growings, news entrants in 2018, ranking from differnt perspectives, including patent filing intensity, academic research capability, news media heat. The company list is generated from various data types.

A lysosome (/ˈlaɪsəˌsoʊm/) is a membrane-bound organelle found in many animal cells. They are spherical vesicles that contain hydrolytic enzymes that can break down many kinds of biomolecules. A lysosome has a specific composition, of both its membrane proteins, and its lumenal proteins. The lumen's pH (~4.5–5.0) is optimal for the enzymes involved in hydrolysis, analogous to the activity of the stomach. Besides degradation of polymers, the lysosome is involved in various cell processes, including secretion, plasma membrane repair, cell signaling, and energy metabolism.

1	BioInvent International AB	Sweden	Antibody,Medicine,Biotechnology, ...[+2]	patent citation: 2,223
2	Bristol Myers Squibb Co.	New York, United States	Medicine,Health care,Oncology drugs, ...[+2]	patent citation: 1,746
3	Bristol Myers Co.	New York, United States	Botanical drug,Herb	patent citation: 1,746
4	Genzyme Corp.	Massachusetts, United States	Medicine,Pharmacy and Therapeutics,Multiple sclerosis, ...[+2]	patent citation: 1,303
5	BioMarin Pharmaceutical, Inc.	California, United States	Software development,Biopharmaceutical,Clinical trial, ...[+2]	patent citation: 744
6	Virginia Tech Intellectual Properties, Inc.	Virginia, United States	Software,Medical imaging,Digital library, ...[+2]	patent citation: 259
7	CropTech Development Corp.	VA, US		patent citation: 259
8	Amicus Therapeutics, Inc.	New Jersey, United States	Pharmacological chaperone,Medicine,Health care, ...[+2]	patent citation: 194
9	Photocure ASA	New Jersey, United States	Photodynamic diagnosis,Medicine,Lifestyle drug, ...[+2]	patent citation: 181
10	Protalix Ltd.	Haifa, Israel		patent citation: 173
11	Shire Human Genetic Therapies, Inc.	Massachusetts, United States	Medicine	patent citation: 143
12	Takeda Pharmaceutical Co., Ltd.	Osaka, Japan	Medicine,Health care,Clinical trial, ...[+2]	patent citation: 114
13	Takeda Chemical Industries Ltd.	Japan	Pharmaceutical drug,Botanical drug,Herb	patent citation: 114
14	Radiumhospitalets Forskningsstiftelse	AK, NO	Cancer research,Cancer cluster	patent citation: 105
15	Symbiontics, Inc.	MO, US		patent citation: 105
16	Becton, Dickinson & Co.	Haryana, India	Medical equipment,Health care,Surgical Specialty, ...[+2]	patent citation: 87
17	Becton, Dickinson & Co. Ltd.	Dublin, Ireland	Medical equipment,Medicine	patent citation: 87
18	UCSF Benioff Children's Hospital Oakland	California, United States	Substance abuse,Health care,Hospitality industry, ...[+2]	patent citation: 85
19	Maxygen, Inc.	California, United States	Directed evolution,DNA shuffling,Molecular breeding, ...[+2]	patent citation: 82
20	Medtronic, Inc.	Minnesota, United States	Medicine,Implantable cardiac pacemaker,Biomedical engineering, ...[+2]	patent citation: 80
21	Perseid Therapeutics LLC	California, United States	DNA shuffling,Medicine,Modalities	patent citation: 76
22	Merck & Co., Inc.	New Jersey, United States	Health care,Biopharmaceutical,Drug, ...[+2]	patent citation: 74
23	Biocept, Inc.	California, United States	Health care,Circulating tumor DNA,Circulating tumor cell, ...[+2]	patent citation: 73
24	JCR Pharmaceuticals Co., Ltd.	Hokkaido, Japan	Raw material,Drug,Medicine, ...[+2]	patent citation: 60
25	Crucell NV	Zuid-Holland, Netherlands	Health care,Pharmacy and Therapeutics,Drug, ...[+2]	patent citation: 54
26	Janssen Vaccines & Prevention BV	Zuid-Holland, Netherlands	Type I hypersensitivity,Medicine,Cancer immunotherapy, ...[+1]	patent citation: 54
27	Sarepta Therapeutics, Inc.	Massachusetts, United States	Pharmacy and Therapeutics,Health care,Approved drug, ...[+2]	patent citation: 53
28	Zymenex A/S	Hovedstaden, Denmark	Clinical trial,Pharmacy and Therapeutics,Medicine, ...[+2]	patent citation: 50
29	ALZA Corp.	California, United States	Health care,Pharmacy and Therapeutics,Medical product, ...[+2]	patent citation: 49
30	Merck Sharp & Dohme Corp.	New Jersey, United States	Prescription drug,Medicine,Stroke, ...[+2]	patent citation: 48
31	Ambrx, Inc.	California, United States	Biology,Pharmacy and Therapeutics,Dosing Frequency, ...[+2]	patent citation: 48
32	PRP LLC	District of Columbia, United States	Alternative investment,Asset management	patent citation: 44
33	Angiochem, Inc.	Quebec, Canada	Drug,Medicine,Health care, ...[+2]	patent citation: 42
34	ERYTech Pharma SA	Rhône-Alpes, France	Medicine,Health care,Hematology, ...[+2]	patent citation: 41
35	Kentucky BioProcessing LLC	Kentucky, United States	American tobacco,Chemical engineering	patent citation: 41
36	Bayer HealthCare AG	Nordrhein-Westfalen, Germany	Health care,Diabetes Therapy,Immunoprotein, ...[+2]	patent citation: 37
37	Pharmacia Corp.	New Jersey, United States	Botanical drug,Herb,Ophthalmology, ...[+2]	patent citation: 37
38	Ixsys, Inc.	California, United States	Software,Human resource management,Payroll	patent citation: 31
39	biOasis Advanced Technologies, Inc.	CA		patent citation: 28
40	Bayer AG	Nordrhein-Westfalen, Germany	Health care,Biology,Chemical engineering, ...[+2]	patent citation: 27
41	Massachusetts General Hospital	Massachusetts, United States	Substance abuse,Hospitality industry,Health care, ...[+2]	patent citation: 27
42	The General Hospital Corp.	Massachusetts, United States	Health care,Hospitality industry,Vascular Medicine, ...[+2]	patent citation: 27
43	Neuraltus Pharmaceuticals, Inc.	California, United States	Fabry's disease,Medicine,Health care, ...[+2]	patent citation: 27
44	STARTUP Prevail Therapeutics, Inc.	New York, United States	Gene,Health care,Pharmacy and Therapeutics, ...[+2]	patent citation: 27
45	Bayer Oy	Finland		patent citation: 27
46	Ildong Pharmaceutical Co., Ltd.	South Korea	Health care,Pill,Antibiotics, ...[+2]	patent citation: 23
47	Valerion Therapeutics LLC	Massachusetts, United States	Medicine,Pharmacy and Therapeutics,Alglucosidase alfa, ...[+2]	patent citation: 23
48	Vakzine Projekt Management GmbH	Niedersachsen, Germany	Small molecule,Medicine,Drug development, ...[+2]	patent citation: 23
49	Bayer Healthcare LLC	New Jersey, United States	Pharmaceutical medicine,Medicine,Computed tomography, ...[+2]	patent citation: 22
50	UCL Business Ltd.	United Kingdom	Intellectual property,Lampalizumab,Angiogenesis inhibitor, ...[+2]	patent citation: 22
51	biOasis Technologies, Inc.	British Columbia, Canada	Biopharmaceutical,Brain cancers,Biomedicine, ...[+2]	patent citation: 21
52	Fondazione Telethon	Lombardia, Italy	Gene delivery,Cell therapy,Plasmid, ...[+2]	patent citation: 21
53	Ramot at Tel Aviv University Ltd.	Tel Aviv, Israel	Technology transfer,Industrial engineering,Biophysics, ...[+2]	patent citation: 19
54	PerkinElmer Health Sciences, Inc.	MA, US	Medicine	patent citation: 18
55	Large Scale Biology Corp.	California, United States	Health care	patent citation: 18
56	Helix Therapeutics, Inc.	Connecticut, United States	Pharmacy and Therapeutics,Sickle cell anemia,Thalassemia, ...[+2]	patent citation: 17
57	Olympus Corp.	Tokyo, Japan	Microscope,Endoscopy,Software, ...[+2]	patent citation: 16
58	Eiken Chemical Co., Ltd.	Tokyo, Japan	Reagent,Medical equipment,Fecal occult blood, ...[+2]	patent citation: 16
59	Synageva BioPharma Corp.	Massachusetts, United States	Botanical drug,Herb,Accelerated atherosclerosis, ...[+2]	patent citation: 15
60	Research Development Foundation	United States	Plasmid,Molecular medicine,Cardiovascular agent, ...[+2]	patent citation: 15
61	Bristol-Myers Squibb FCT bêta, Inc.	Texas, United States	Health care,Biological pathway,Biopharmaceutical, ...[+2]	patent citation: 14
62	Enzon Pharmaceuticals, Inc.	New Jersey, United States	Medicine,Health care,PEGylation, ...[+2]	patent citation: 13
63	Arrogene, Inc.	California, United States	Cancer,Medicine,Drug	patent citation: 13
64	Arrogene	California, United States	Glioma,Pre-clinical development,Cancer	patent citation: 13
65	Oncologic, Inc.	CA, US		patent citation: 13
66	Innovative Biotech Pte Ltd.	SG	Biotechnology,Medical equipment,Drug, ...[+1]	patent citation: 13
67	Consiglio Nazionale delle Ricerche	Lazio, Italy	Research system,Internationalization	patent citation: 12
68	Bayer Pharma AG	Berlin, Germany	Medicine,Nuclear medicine,Andrology, ...[+2]	patent citation: 10
69	StemCells California, Inc.	California, United States		patent citation: 10
70	Alexion Pharmaceuticals, Inc.	Connecticut, United States	Health care,Biopharmaceutical,Clinical trial, ...[+2]	patent citation: 9
71	Nanjing Mingde New Drug Research and Development Co., Ltd.			patent citation: 9
72	Panacea Pharmaceuticals, Inc.	United States	Medicine,Health care,Lymphokine, ...[+2]	patent citation: 8
73	Ocuphire Pharma, Inc.	Michigan, United States	OPHTHALMIC DISORDERS,Glaucoma,Eye drop, ...[+2]	patent citation: 8
74	Seikagaku Corp.	Tokyo, Japan	Viscosupplementation,Health care,SURGICAL AIDS, ...[+2]	patent citation: 7
75	Allergan, Inc.	CA, US	Over-the-counter,Dermatology,Botanical drug, ...[+2]	patent citation: 7
76	Uwm Research Foundation, Inc.	Wisconsin, United States		patent citation: 7
77	BCN Peptides SA	Cataluña, Spain	Peptide,Chemical engineering,Retinopathy, ...[+2]	patent citation: 7
78	Regeneron Pharmaceuticals, Inc.	New York, United States	Monoclonal antibody,Clinical trial,Cholesterol, ...[+2]	patent citation: 6
79	Nektar Therapeutics	California, United States	Biopharmaceutical,Chemical engineering,Health care, ...[+2]	patent citation: 6
80	Asklepios BioPharmaceutical, Inc.	North Carolina, United States	Biopharmaceutical,Health care,Gene delivery, ...[+2]	patent citation: 6
81	Rexahn Pharmaceuticals, Inc.	United States	Medicine,Medical equipment,Drug, ...[+2]	patent citation: 6
82	STARTUP Ligandal, Inc.	New York, United States	CRISPR,Coronavirus disease 2019 (COVID-19),Cell therapy, ...[+2]	patent citation: 6
83	Transactiva Srl	Udine, Italy	Biopharmaceutical,Drug,Biological drugs, ...[+1]	patent citation: 6
84	Nektar Therapeutics AL Corp.	Alabama, United States	Ethylene glycol,Ethylene,Chemical engineering	patent citation: 6
85	Genmab A/S	Hovedstaden, Denmark	Health care,Antibody,Biotechnology, ...[+2]	patent citation: 5
86	Q Therapeutics, Inc.	Utah, United States	Medicine,Health care,Pharmacy and Therapeutics, ...[+2]	patent citation: 5
87	Introgene BV	Zuid-Holland, Netherlands		patent citation: 5
88	Tokyo Metropolitan Institute of Medical Science	Japan	Biotechnology,Agriculture,Chemistry, ...[+2]	patent citation: 5
89	Abbott Laboratories Ltd.	United Kingdom	Medicine,Photomedicine,Drug carrier, ...[+2]	patent citation: 5
90	Genmab BV	Netherlands		patent citation: 5
91	Horizon Orphan LLC	Illinois, United States	Medicine	patent citation: 5
92	InnoBM Pharmaceutics Co. Ltd.	China		patent citation: 5
93	Toray Industries, Inc.	Tokyo, Japan	Fiber,Textile,Textile (markup language), ...[+2]	patent citation: 4
94	Asahi Kasei Corp.	Tokyo, Japan	Chemical engineering,Petrochemical,Fertilizer, ...[+2]	patent citation: 4
95	Green Cross Co., Ltd.	Fukuoka, Japan	Oil well,DNA vaccination,Oncology drugs, ...[+2]	patent citation: 4
96	Fina Biotech SL	Madrid, Spain	Biotechnology,Venture capital,Health care, ...[+1]	patent citation: 4
97	Biographene Co., Ltd.	GY, KR	Electronics	patent citation: 4
98	Marker Gene Technologies, Inc.	Oregon, United States	Biotechnology,Microarray,Marker gene, ...[+2]	patent citation: 4
99	Astellas Pharma, Inc.	Tokyo, Japan	Health care,Clinical trial,Diabetic complication, ...[+2]	patent citation: 3
100	FUJIFILM Corp.	Tokyo, Japan	Photography,Medical imaging,Computer hardware, ...[+2]	patent citation: 3