Top 100 Key Players companies in Lysosome by Most Patent Filings in the world in 2019 – Discovery

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The Lysosome top 100 is Discovery PatSnap’ annual ranking of the top 100 Most Patent Filings Lysosome Key Players in the world. Discovery has identified the top key players, startups & unicorns, fast-growings, news entrants in 2019, ranking from differnt perspectives, including patent filing intensity, academic research capability, news media heat. The company list is generated from various data types.

A lysosome (/ˈlaɪsəˌsoʊm/) is a membrane-bound organelle found in many animal cells. They are spherical vesicles that contain hydrolytic enzymes that can break down many kinds of biomolecules. A lysosome has a specific composition, of both its membrane proteins, and its lumenal proteins. The lumen's pH (~4.5–5.0) is optimal for the enzymes involved in hydrolysis, analogous to the activity of the stomach. Besides degradation of polymers, the lysosome is involved in various cell processes, including secretion, plasma membrane repair, cell signaling, and energy metabolism.

1	BioMarin Pharmaceutical, Inc.	California, United States	Software development,Biopharmaceutical,Clinical trial, ...[+2]	Patent: 150
2	Shire Human Genetic Therapies, Inc.	Massachusetts, United States	Medicine	Patent: 150
3	Genzyme Corp.	Massachusetts, United States	Medicine,Pharmacy and Therapeutics,Multiple sclerosis, ...[+2]	Patent: 106
4	Amicus Therapeutics, Inc.	New Jersey, United States	Pharmacological chaperone,Medicine,Health care, ...[+2]	Patent: 97
5	STARTUP Prevail Therapeutics, Inc.	New York, United States	Gene,Health care,Pharmacy and Therapeutics, ...[+2]	Patent: 56
6	Angiochem, Inc.	Quebec, Canada	Drug,Medicine,Health care, ...[+2]	Patent: 44
7	Regeneron Pharmaceuticals, Inc.	New York, United States	Monoclonal antibody,Clinical trial,Cholesterol, ...[+2]	Patent: 42
8	JCR Pharmaceuticals Co., Ltd.	Hokkaido, Japan	Raw material,Drug,Medicine, ...[+2]	Patent: 36
9	Protalix Ltd.	Haifa, Israel		Patent: 34
10	Alexion Pharmaceuticals, Inc.	Connecticut, United States	Health care,Biopharmaceutical,Clinical trial, ...[+2]	Patent: 28
11	Takeda Pharmaceutical Co., Ltd.	Osaka, Japan	Medicine,Health care,Clinical trial, ...[+2]	Patent: 25
12	Takeda Chemical Industries Ltd.	Japan	Pharmaceutical drug,Botanical drug,Herb	Patent: 25
13	Astellas Pharma, Inc.	Tokyo, Japan	Health care,Clinical trial,Diabetic complication, ...[+2]	Patent: 21
14	Synageva BioPharma Corp.	Massachusetts, United States	Botanical drug,Herb,Accelerated atherosclerosis, ...[+2]	Patent: 21
15	Photocure ASA	New Jersey, United States	Photodynamic diagnosis,Medicine,Lifestyle drug, ...[+2]	Patent: 19
16	PerkinElmer Health Sciences, Inc.	MA, US	Medicine	Patent: 19
17	Sarepta Therapeutics, Inc.	Massachusetts, United States	Pharmacy and Therapeutics,Health care,Approved drug, ...[+2]	Patent: 18
18	Vakzine Projekt Management GmbH	Niedersachsen, Germany	Small molecule,Medicine,Drug development, ...[+2]	Patent: 18
19	Transactiva Srl	Udine, Italy	Biopharmaceutical,Drug,Biological drugs, ...[+1]	Patent: 18
20	Fondazione Telethon	Lombardia, Italy	Gene delivery,Cell therapy,Plasmid, ...[+2]	Patent: 17
21	biOasis Technologies, Inc.	British Columbia, Canada	Biopharmaceutical,Brain cancers,Biomedicine, ...[+2]	Patent: 16
22	Esteve Pharmaceuticals S.A.	Cataluña, Spain	Ophthalmology,Pathology,Pharmacy, ...[+2]	Patent: 16
23	ESTEVE	Cataluña, Spain	Drug,Medicine,Health care, ...[+2]	Patent: 16
24	Bayer HealthCare AG	Nordrhein-Westfalen, Germany	Health care,Diabetes Therapy,Immunoprotein, ...[+2]	Patent: 14
25	Asklepios BioPharmaceutical, Inc.	North Carolina, United States	Biopharmaceutical,Health care,Gene delivery, ...[+2]	Patent: 14
26	Swedish Orphan Biovitrum AB	Sweden	Medicine,Clinical trial,Biotechnology, ...[+2]	Patent: 13
27	Bayer Healthcare LLC	New Jersey, United States	Pharmaceutical medicine,Medicine,Computed tomography, ...[+2]	Patent: 13
28	Bayer AG	Nordrhein-Westfalen, Germany	Health care,Biology,Chemical engineering, ...[+2]	Patent: 12
29	Sangamo Therapeutics, Inc.	California, United States	Cell,Pharmacy and Therapeutics,Genomics, ...[+2]	Patent: 12
30	ALZA Corp.	California, United States	Health care,Pharmacy and Therapeutics,Medical product, ...[+2]	Patent: 12
31	BCN Peptides SA	Cataluña, Spain	Peptide,Chemical engineering,Retinopathy, ...[+2]	Patent: 12
32	Bayer Oy	Finland		Patent: 12
33	Merck & Co., Inc.	New Jersey, United States	Health care,Biopharmaceutical,Drug, ...[+2]	Patent: 11
34	Bristol-Myers Squibb FCT bêta, Inc.	Texas, United States	Health care,Biological pathway,Biopharmaceutical, ...[+2]	Patent: 11
35	Seikagaku Corp.	Tokyo, Japan	Viscosupplementation,Health care,SURGICAL AIDS, ...[+2]	Patent: 10
36	Denali Therapeutics, Inc.	California, United States	Biotechnology,Pharmacy and Therapeutics,Biological process, ...[+2]	Patent: 10
37	Bristol Myers Squibb Co.	New York, United States	Medicine,Health care,Oncology drugs, ...[+2]	Patent: 9
38	CHIESI Farmaceutici SpA	Emilia-Romagna, Italy	Inhaler,Neonatology,Medicine, ...[+2]	Patent: 9
39	Bayer Pharma AG	Berlin, Germany	Medicine,Nuclear medicine,Andrology, ...[+2]	Patent: 9
40	Rexahn Pharmaceuticals, Inc.	United States	Medicine,Medical equipment,Drug, ...[+2]	Patent: 9
41	Bristol Myers Co.	New York, United States	Botanical drug,Herb	Patent: 9
42	Q Therapeutics, Inc.	Utah, United States	Medicine,Health care,Pharmacy and Therapeutics, ...[+2]	Patent: 8
43	UCL Business Ltd.	United Kingdom	Intellectual property,Lampalizumab,Angiogenesis inhibitor, ...[+2]	Patent: 8
44	STARTUP IntraBio Ltd.	Oxfordshire, United Kingdom	Clinical trial,Medicine,Drug, ...[+2]	Patent: 8
45	STARTUP Ligandal, Inc.	New York, United States	CRISPR,Coronavirus disease 2019 (COVID-19),Cell therapy, ...[+2]	Patent: 8
46	Plantechno Srl	CR, IT	Biotechnology,Gene	Patent: 8
47	StemCells California, Inc.	California, United States		Patent: 8
48	Yantai Heyuanaidisi Biomedical Technology Co Ltd	China		Patent: 8
49	Merck Sharp & Dohme Corp.	New Jersey, United States	Prescription drug,Medicine,Stroke, ...[+2]	Patent: 7
50	Ospedale San Raffaele Srl	Lombardia, Italy	Pathology,Health care,Hospitality industry, ...[+2]	Patent: 7
51	Protec Co., Ltd.	South Korea	Semiconductor,Pneumatic cylinder,Electronic component, ...[+1]	Patent: 7
52	Eleva GmbH	Baden-Württemberg, Germany	Fabry's disease,Therapeutic protein,Technology transfer, ...[+2]	Patent: 7
53	Valerion Therapeutics LLC	Massachusetts, United States	Medicine,Pharmacy and Therapeutics,Alglucosidase alfa, ...[+2]	Patent: 7
54	Marker Gene Technologies, Inc.	Oregon, United States	Biotechnology,Microarray,Marker gene, ...[+2]	Patent: 7
55	Becton, Dickinson & Co.	Haryana, India	Medical equipment,Health care,Surgical Specialty, ...[+2]	Patent: 6
56	Vertex Pharmaceuticals, Inc.	Massachusetts, United States	Health care,Medicine,Cystic fibrosis, ...[+2]	Patent: 6
57	Medtronic, Inc.	Minnesota, United States	Medicine,Implantable cardiac pacemaker,Biomedical engineering, ...[+2]	Patent: 6
58	Pharmacia Corp.	New Jersey, United States	Botanical drug,Herb,Ophthalmology, ...[+2]	Patent: 6
59	Massachusetts General Hospital	Massachusetts, United States	Substance abuse,Hospitality industry,Health care, ...[+2]	Patent: 6
60	Maxygen, Inc.	California, United States	Directed evolution,DNA shuffling,Molecular breeding, ...[+2]	Patent: 6
61	The General Hospital Corp.	Massachusetts, United States	Health care,Hospitality industry,Vascular Medicine, ...[+2]	Patent: 6
62	Ramot at Tel Aviv University Ltd.	Tel Aviv, Israel	Technology transfer,Industrial engineering,Biophysics, ...[+2]	Patent: 6
63	Large Scale Biology Corp.	California, United States	Health care	Patent: 6
64	Immunomic Therapeutics, Inc.	Pennsylvania, United States	Biology,Medicine,Pharmacy and Therapeutics, ...[+2]	Patent: 6
65	STARTUP NEUWAY Pharma GmbH	Nordrhein-Westfalen, Germany	Health care,Progressive multifocal leukoencephalopathy,Metachromatic leukodystrophy, ...[+2]	Patent: 6
66	Neuraltus Pharmaceuticals, Inc.	California, United States	Fabry's disease,Medicine,Health care, ...[+2]	Patent: 6
67	Becton, Dickinson & Co. Ltd.	Dublin, Ireland	Medical equipment,Medicine	Patent: 6
68	Nanjing Mingde New Drug Research and Development Co., Ltd.			Patent: 6
69	FUJIFILM Corp.	Tokyo, Japan	Photography,Medical imaging,Computer hardware, ...[+2]	Patent: 5
70	Allergan, Inc.	CA, US	Over-the-counter,Dermatology,Botanical drug, ...[+2]	Patent: 5
71	Consiglio Nazionale delle Ricerche	Lazio, Italy	Research system,Internationalization	Patent: 5
72	Orphazyme A/S	Hovedstaden, Denmark	Lysosomal storage disease,Medicine,Pharmacy and Therapeutics, ...[+2]	Patent: 5
73	ERYTech Pharma SA	Rhône-Alpes, France	Medicine,Health care,Hematology, ...[+2]	Patent: 5
74	BioInvent International AB	Sweden	Antibody,Medicine,Biotechnology, ...[+2]	Patent: 5
75	Biocept, Inc.	California, United States	Health care,Circulating tumor DNA,Circulating tumor cell, ...[+2]	Patent: 5
76	Centogene AG	Mecklenburg-Vorpommern, Germany	Clinical trial,Health care,Genetic analysis, ...[+2]	Patent: 5
77	STARTUP Evox Therapeutics Ltd.	Oxfordshire, United Kingdom	Exosome,Health care,Genomics, ...[+2]	Patent: 5
78	STARTUP Lycia Therapeutics, Inc.	California, United States	Biotechnology,Health care,Biology	Patent: 5
79	Virginia Tech Intellectual Properties, Inc.	Virginia, United States	Software,Medical imaging,Digital library, ...[+2]	Patent: 5
80	CropTech Development Corp.	VA, US		Patent: 5
81	Taisho Pharmaceutical Co., Ltd.	Tokyo, Japan	Medicine,Self-medication,Drug, ...[+2]	Patent: 4
82	Crucell NV	Zuid-Holland, Netherlands	Health care,Pharmacy and Therapeutics,Drug, ...[+2]	Patent: 4
83	Applied Genetic Technologies Corp.	United States	Gene,Health care,Genomics, ...[+2]	Patent: 4
84	PRP LLC	District of Columbia, United States	Alternative investment,Asset management	Patent: 4
85	Arrogene, Inc.	California, United States	Cancer,Medicine,Drug	Patent: 4
86	Janssen Vaccines & Prevention BV	Zuid-Holland, Netherlands	Type I hypersensitivity,Medicine,Cancer immunotherapy, ...[+1]	Patent: 4
87	Ambrx, Inc.	California, United States	Biology,Pharmacy and Therapeutics,Dosing Frequency, ...[+2]	Patent: 4
88	UbiVac, Inc.	Oregon, United States	Immunotherapy,Medicine,Wellness Programs, ...[+2]	Patent: 4
89	Kentucky BioProcessing LLC	Kentucky, United States	American tobacco,Chemical engineering	Patent: 4
90	Arrogene	California, United States	Glioma,Pre-clinical development,Cancer	Patent: 4
91	Sanofi-Aventis Ltd.	United Kingdom	Medicine,Thrombosis,Metabolic disorder, ...[+2]	Patent: 4
92	Research Development Foundation	United States	Plasmid,Molecular medicine,Cardiovascular agent, ...[+2]	Patent: 4
93	PCI Biotech AS	Akershus, Norway	Vaccination,Bile duct cancer,Cancer vaccine, ...[+2]	Patent: 4
94	University of Washington Center for Commercialization	WA, US		Patent: 4
95	Ixsys, Inc.	California, United States	Software,Human resource management,Payroll	Patent: 4
96	Olympus Corp.	Tokyo, Japan	Microscope,Endoscopy,Software, ...[+2]	Patent: 3
97	Green Cross Co., Ltd.	Fukuoka, Japan	Oil well,DNA vaccination,Oncology drugs, ...[+2]	Patent: 3
98	Eiken Chemical Co., Ltd.	Tokyo, Japan	Reagent,Medical equipment,Fecal occult blood, ...[+2]	Patent: 3
99	Enzon Pharmaceuticals, Inc.	New Jersey, United States	Medicine,Health care,PEGylation, ...[+2]	Patent: 3
100	Nihon Shokuhin Kako Co., Ltd.	Tokyo, Japan	Starch,Food industry,Food processing, ...[+2]	Patent: 3