Top 100 Key Players companies in Microorganism by Highest Patent Value in the world in 2018 – Discovery

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The Microorganism top 100 is Discovery PatSnap’ annual ranking of the top 100 Highest Patent Value Microorganism Key Players in the world. Discovery has identified the top key players, startups & unicorns, fast-growings, news entrants in 2018, ranking from differnt perspectives, including patent filing intensity, academic research capability, news media heat. The company list is generated from various data types.

A microorganism, or microbe, is a microscopic organism, which may exist in its single-celled form or in a colony of cells. The possible existence of unseen microbial life was suspected from ancient times, such as in Jain scriptures from 6th century BC India and the 1st century BC book On Agriculture by Marcus Terentius Varro. Microbiology, the scientific study of microorganisms, began with their observation under the microscope in the 1670s by Antonie van Leeuwenhoek. In the 1850s, Louis Pasteur found that microorganisms caused food spoilage, debunking the theory of spontaneous generation. In the 1880s, Robert Koch discovered that microorganisms caused the diseases tuberculosis, cholera and anthrax.

1	Apple, Inc.	California, United States	Software,Computer hardware,Peripheral, ...[+2]	Avg patent value: 13.90 M
2	Johnson & Johnson	New Jersey, United States	Health care,Medical equipment,Risperidone, ...[+2]	Avg patent value: 11.05 M
3	Gilead Biologics, Inc.	Delaware, United States	Medicine	Avg patent value: 11.00 M
4	Kirin-Amgen, Inc.	California, United States	Pharmaceutical drug,Medicine	Avg patent value: 10.99 M
5	Brookhaven Science Associates LLC	New York, United States		Avg patent value: 10.94 M
6	Rinat Neuroscience Corp.	California, United States	Neuroscience,Antibody,Medicine, ...[+2]	Avg patent value: 10.53 M
7	Essex Industries, Inc.	Connecticut, United States	Headframe,Eye protection,Fall protection, ...[+2]	Avg patent value: 10.15 M
8	Sterilecare, Inc.	Ontario, Canada	Serious infection	Avg patent value: 10.09 M
9	Aseptica, Inc.	Washington, United States		Avg patent value: 10.09 M
10	Ocean Nutrition Canada Ltd.	Nova Scotia, Canada	Food industry,Health care,Nutrition, ...[+2]	Avg patent value: 9.76 M
11	Anacor Pharmaceuticals, Inc.	California, United States	Medicine,Health care,Boron, ...[+2]	Avg patent value: 9.51 M
12	Achaogen, Inc.	California, United States	Antibiotics,Health care,Medicine, ...[+2]	Avg patent value: 9.28 M
13	Verdinck Holding BV	Noord-Brabant, Netherlands	Chemical engineering	Avg patent value: 8.98 M
14	C5 Yeast Co. BV	Noord-Brabant, Netherlands	Yeast	Avg patent value: 8.98 M
15	Dong-A Socio Holdings Co., Ltd.	South Korea	Clinical trial,Medicine,Over-the-counter, ...[+2]	Avg patent value: 8.97 M
16	Dong-A ST Co., Ltd.	South Korea	Medicine,Mucous membrane,Growth hormone, ...[+2]	Avg patent value: 8.97 M
17	Dong-A Pharmaceutical Co., Ltd.	South Korea	Medicine,Udenafil,Fidaxomicin, ...[+2]	Avg patent value: 8.97 M
18	STARTUP Mycovia Pharmaceuticals, Inc.	North Carolina, United States	Recurrent vulvovaginal candidiasis,Drug,Biomedicine, ...[+2]	Avg patent value: 8.54 M
19	Viamet Pharmaceuticals, Inc.	North Carolina, United States	Amphotericin B,Medical equipment,Medicine, ...[+2]	Avg patent value: 8.54 M
20	Oxyrane UK Ltd.	Manchester, United Kingdom	Alglucosidase alfa,Medicine,Enzyme replacement therapy, ...[+2]	Avg patent value: 8.53 M
21	Roche Glycart AG	Zürich, Switzerland	Antibody,Medicine,Health care, ...[+2]	Avg patent value: 8.52 M
22	EnGeneIC Molecular Delivery Pty Ltd.	Australia		Avg patent value: 8.06 M
23	Medivation Prostate Therapeutics LLC	California, United States	Drug,Medicine	Avg patent value: 8.04 M
24	Oro Agri, Inc.	California, United States	Pesticide,Agriculture,Chemical engineering, ...[+2]	Avg patent value: 7.94 M
25	BASF Plant Science LLC	New Jersey, United States	Starch,Fertilizer,Plant science	Avg patent value: 7.89 M
26	TerraVia Holdings, Inc.	California, United States	Biofuel,Chemical engineering,Algae, ...[+2]	Avg patent value: 7.72 M
27	Revance Therapeutics, Inc.	California, United States	Botulinum toxin,Medicine,Health care, ...[+2]	Avg patent value: 7.64 M
28	Abunda Nutrition, Inc.	California, United States	Nutrition	Avg patent value: 7.55 M
29	TotalEnergies SE	Île-de-France, France	Solar energy,Petroleum,Renewable energy, ...[+2]	Avg patent value: 7.51 M
30	Total Co. Ltd.	China	Industrial engineering	Avg patent value: 7.51 M
31	Otsuka Pharmaceutical Co., Ltd.	Tokyo, Japan	Nutraceutical,Health care,Cosmetics, ...[+2]	Avg patent value: 7.42 M
32	Toyama Chemical Co., Ltd.	Tokyo, Japan	Pharmacy,Drug,Certolizumab pegol, ...[+2]	Avg patent value: 7.42 M
33	Nabriva Therapeutics GmbH	Wien, Austria	Health care,Pleuromutilin,Medicine, ...[+2]	Avg patent value: 7.41 M
34	Baxalta, Inc.	Illinois, United States	Biopharmaceutical,Medicine,Biotechnology, ...[+2]	Avg patent value: 7.34 M
35	Baxalta GmbH	Zürich, Switzerland	Drug,Medicine	Avg patent value: 7.34 M
36	Trius Therapeutics, Inc.	Massachusetts, United States	Medicine,Health care,Tedizolid, ...[+2]	Avg patent value: 7.26 M
37	Syngenta Crop Protection AG	Switzerland	Pesticide,Agriculture,Chemical engineering, ...[+2]	Avg patent value: 7.16 M
38	Tibotec Pharmaceuticals	Ireland		Avg patent value: 7.10 M
39	FibroGen, Inc.	California, United States	Pharmacy and Therapeutics,CTGF,Idiopathic pulmonary fibrosis, ...[+2]	Avg patent value: 7.07 M
40	Zoetis Belgium SA	Belgium	Medicine	Avg patent value: 7.06 M
41	Merck & Co., Inc.	New Jersey, United States	Health care,Biopharmaceutical,Drug, ...[+2]	Avg patent value: 6.98 M
42	Merck Sharp & Dohme Corp.	New Jersey, United States	Prescription drug,Medicine,Stroke, ...[+2]	Avg patent value: 6.98 M
43	Athenex, Inc.	New York, United States	Health care,Proprietary drug,Biotechnology, ...[+2]	Avg patent value: 6.93 M
44	Mitsubishi Power Ltd.	Kanagawa, Japan	Turbine,Control system,Renewable energy, ...[+2]	Avg patent value: 6.60 M
45	Mitsubishi Hitachi Power Systems	Kanagawa, Japan	Control system	Avg patent value: 6.60 M
46	Morphochem AG für Kombinatorische Chemie	Germany	Medicine	Avg patent value: 6.53 M
47	Ferring BV	Noord-Holland, Netherlands	Gastroenterology,Viscosupplementation,Infertility, ...[+2]	Avg patent value: 6.49 M
48	Fina Research SA	Belgium		Avg patent value: 6.45 M
49	CHIESI Farmaceutici SpA	Emilia-Romagna, Italy	Inhaler,Neonatology,Medicine, ...[+2]	Avg patent value: 6.18 M
50	Hayashibara Co., Ltd.	Okayama, Japan	Food industry,Snack foods,Starch, ...[+2]	Avg patent value: 6.13 M
51	Hayashibara Shoji, Inc.	Okayama, Japan	Medical equipment,Trehalose,Pullulan, ...[+2]	Avg patent value: 6.13 M
52	4D Pharma Plc	Aberdeen City, United Kingdom	Medicine,Health care,Microbiome, ...[+2]	Avg patent value: 6.04 M
53	Gowan Co. LLC	Arizona, United States	Pesticide,Crop,Agriculture, ...[+2]	Avg patent value: 5.99 M
54	Janssen Sciences Ireland Unlimited Co.	Ireland		Avg patent value: 5.92 M
55	Corbion Biotech, Inc.	United States		Avg patent value: 5.87 M
56	LiveLeaf, Inc.	California, United States	Gastrointestinal agent,Plant Immunity,Health care, ...[+2]	Avg patent value: 5.86 M
57	DSM Nutritional Products AG	Switzerland	Vitamin,Carotenoid,Chemical engineering, ...[+2]	Avg patent value: 5.83 M
58	Pierre Fabre Médicament SAS	Île-de-France, France	Oncology,Cosmetics,Pharmacy, ...[+1]	Avg patent value: 5.83 M
59	Wyeth LLC	New Jersey, United States		Avg patent value: 5.79 M
60	Wellstat Therapeutics Corp.	United States	Drug discovery,Pharmacy,Drug development, ...[+2]	Avg patent value: 5.74 M
61	Nutrition & Biosciences USA 2 LLC	New York, United States		Avg patent value: 5.72 M
62	Pergamum AB	Stockholm, Sweden	Peptide,Medicine	Avg patent value: 5.69 M
63	neo ALA Co. Ltd.	Abu Dhabi, United Arab Emirates	Medicine	Avg patent value: 5.61 M
64	Romark LC	United States	Medicine,Medical equipment,Small molecule, ...[+2]	Avg patent value: 5.60 M
65	Bavarian Nordic A/S	Hovedstaden, Denmark	Cancer immunotherapy,Health care,Medicine, ...[+2]	Avg patent value: 5.58 M
66	Bavarian Nordic, Inc.	North Carolina, United States	Drug,Medicine	Avg patent value: 5.58 M
67	Stratatech Corp.	Wisconsin, United States	Wound healing,Health care,Skin tissue, ...[+2]	Avg patent value: 5.56 M
68	aXichem AB	Sweden	Nutraceutical,Chemical engineering	Avg patent value: 5.48 M
69	H.J. Heinz Company Brands LLC	Illinois, United States	Software as a service,Enterprise software,Software development, ...[+2]	Avg patent value: 5.46 M
70	Nutricia NV	Zuid-Holland, Netherlands	Food industry	Avg patent value: 5.46 M
71	Mebiol, Inc.	Kanagawa, Japan	Cultivation System,Farming industry,Agriculture	Avg patent value: 5.33 M
72	Ambrx, Inc.	California, United States	Biology,Pharmacy and Therapeutics,Dosing Frequency, ...[+2]	Avg patent value: 5.33 M
73	Constellation Brands, Inc.	New York, United States	Wine,Canopy,Winemaking, ...[+2]	Avg patent value: 5.28 M
74	McNeil-PPC, Inc.	Pennsylvania, United States	Personal Care Product,Medicine,Health care, ...[+2]	Avg patent value: 5.28 M
75	TOP Industri AB	Örebro, Sweden	Air dryer	Avg patent value: 5.23 M
76	POCARED Diagnostics Ltd.	HaMerkaz, Israel	Intubation,Health care,Species identification, ...[+2]	Avg patent value: 5.22 M
77	Genentech, Inc.	California, United States	Biotechnology,Biology,Medicine, ...[+2]	Avg patent value: 5.20 M
78	EirGen Pharma Ltd.	Ireland	Medicine,Health care,Potency, ...[+2]	Avg patent value: 5.19 M
79	Pierre Fabre Dermatologie SAS	Île-de-France, France	Medicine,Clinical trial,Biomedicine, ...[+2]	Avg patent value: 5.19 M
80	Avent, Inc.	Arizona, United States	Medicine	Avg patent value: 5.16 M
81	Johnson & Johnson Vision Care, Inc.	United States	Medical equipment,Health care,Optometry, ...[+2]	Avg patent value: 5.08 M
82	Entasis Therapeutics Ltd.	United Kingdom	Drug,Medicine	Avg patent value: 5.05 M
83	Lallemand, Inc.	Ontario, Canada	Yeast,Food industry,Feed additive, ...[+2]	Avg patent value: 5.01 M
84	Progen Pharmaceuticals, Inc.	North Carolina, United States	Medicine	Avg patent value: 4.99 M
85	Progen PG500 Series Pty Ltd	Australia	Medicine	Avg patent value: 4.99 M
86	ExThera Medical Corp.	California, United States	Hemodialysis,Medical equipment,Health care, ...[+2]	Avg patent value: 4.97 M
87	ExThera AB	Stockholm, Sweden	Medical product,Medicine,In vitro, ...[+1]	Avg patent value: 4.97 M
88	Allied Bioscience, Inc.	Texas, United States	Antimicrobial surface,Mildew,Algae, ...[+2]	Avg patent value: 4.96 M
89	BD Kiestra BV	FRIESLAND, Netherlands	Medicine,Antibody,Reagent	Avg patent value: 4.96 M
90	Bard Shannon Ltd.	Puerto Rico	Medical equipment,Medicine	Avg patent value: 4.94 M
91	Regeneron Pharmaceuticals, Inc.	New York, United States	Monoclonal antibody,Clinical trial,Cholesterol, ...[+2]	Avg patent value: 4.91 M
92	BioGaia AB	Sweden	Health care,Probiotic,Medicine, ...[+2]	Avg patent value: 4.83 M
93	Cipla Ltd.	Maharashtra, India	New Ventures,Medicine,Health care, ...[+2]	Avg patent value: 4.82 M
94	Avery Dennison Corp.	California, United States	Adhesive,Radio-frequency identification,Synthetic rubber, ...[+2]	Avg patent value: 4.77 M
95	Snipr Technologies Ltd.	United Kingdom		Avg patent value: 4.77 M
96	Biomax Technologies, Inc.	British Columbia, Canada	Skin cancer,Catheter	Avg patent value: 4.75 M
97	Elanco Tiergesundheit AG	Basel-Stadt, Switzerland	Medicine,Health care	Avg patent value: 4.71 M
98	Johnson & Johnson Consumer, Inc.	New Jersey, United States	Skin care,Shower gel,Baby powder, ...[+2]	Avg patent value: 4.70 M
99	Genelux Corp.	California, United States	Drug,Immunotherapy,Biopharmaceutical, ...[+2]	Avg patent value: 4.70 M
100	Magnolia Medical Technologies, Inc.	Washington, United States	Medical equipment,Blood culture,Health care, ...[+2]	Avg patent value: 4.69 M