Top 100 Key Players companies in Monoclonal antibody by Highest Patent Value in the United States in 2022 – Discovery

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The Monoclonal antibody top 100 is Discovery PatSnap’ annual ranking of the top 100 Highest Patent Value Monoclonal antibody Key Players in the United States. Discovery has identified the top key players, startups & unicorns, fast-growings, news entrants in 2022, ranking from differnt perspectives, including patent filing intensity, academic research capability, news media heat. The company list is generated from various data types.

Monoclonal antibodies (mAb or moAb) are antibodies that are made by identical immune cells that are all clones of a unique parent cell. Monoclonal antibodies can have monovalent affinity, in that they bind to the same epitope (the part of an antigen that is recognized by the antibody). In contrast, polyclonal antibodies bind to multiple epitopes and are usually made by several different plasma cell (antibody secreting immune cell) lineages. Bispecific monoclonal antibodies can also be engineered, by increasing the therapeutic targets of one single monoclonal antibody to two epitopes.

1	Gilead Biologics, Inc.	Delaware, United States	Medicine	Avg patent value: 11.64 M
2	Weiman Products LLC	Illinois, United States	E-commerce,Food industry,Fast-moving consumer goods, ...[+2]	Avg patent value: 10.57 M
3	Alexion Pharmaceuticals, Inc.	Connecticut, United States	Health care,Biopharmaceutical,Clinical trial, ...[+2]	Avg patent value: 9.85 M
4	Baxter International, Inc.	Illinois, United States	Clinical trial,Drug,Hemodialysis, ...[+2]	Avg patent value: 9.70 M
5	STARTUP Eagle Biologics, Inc.	Massachusetts, United States	Viscosity,Health care,Pharmacy and Therapeutics, ...[+2]	Avg patent value: 9.08 M
6	Baxalta, Inc.	Illinois, United States	Biopharmaceutical,Medicine,Biotechnology, ...[+2]	Avg patent value: 9.07 M
7	Tanox Biosystems, Inc.	Texas, United States	Immune system,Biotechnology,Agriculture, ...[+2]	Avg patent value: 8.99 M
8	La Jolla Institute for Allergy & Immunology	California, United States	Immune system,Health care,Biomedicine, ...[+2]	Avg patent value: 8.96 M
9	Concortis Biosystems Corp.	California, United States	Biotechnology,Biology,Medicine, ...[+2]	Avg patent value: 8.94 M
10	Wyeth LLC	New Jersey, United States		Avg patent value: 8.70 M
11	Robert Bosch Corp.	Michigan, United States	Shopping mall,Truck	Avg patent value: 8.56 M
12	Sanofi-Aventis U.S. LLC	New Jersey, United States	Manufacturing operations,Medicine,Health care, ...[+2]	Avg patent value: 8.45 M
13	UNICORN Intarcia Therapeutics, Inc.	California, United States	Medicine,Medical equipment,Health care, ...[+2]	Avg patent value: 8.43 M
14	Kirin-Amgen, Inc.	California, United States	Pharmaceutical drug,Medicine	Avg patent value: 8.34 M
15	ZymoGenetics, Inc.	Washington, United States	Medicine,Pharmacy and Therapeutics,Protein chemistry, ...[+2]	Avg patent value: 8.22 M
16	Novartis Vaccines & Diagnostics, Inc.	New Jersey, United States	Health care,Medicine	Avg patent value: 8.19 M
17	Dyax Corp.	Massachusetts, United States	Biopharmaceutical,Monoclonal antibody,Medicine, ...[+2]	Avg patent value: 8.04 M
18	STARTUP True North Therapeutics, Inc.	California, United States	Immunotherapy,Health care,Clinical trial, ...[+2]	Avg patent value: 8.02 M
19	Morphotek, Inc.	Pennsylvania, United States	Monoclonal antibody,Antibody,Health care, ...[+2]	Avg patent value: 7.99 M
20	Millennium Pharmaceuticals, Inc.	Massachusetts, United States	Oncology,Health care,Monoclonal antibody, ...[+2]	Avg patent value: 7.93 M
21	Biogen, Inc.	Massachusetts, United States	Neuroscience,Medicine,Health care, ...[+2]	Avg patent value: 7.86 M
22	Amgen Fremont, Inc.	California, United States	Monoclonal antibody therapy,Medicine,Monoclonal antibody	Avg patent value: 7.80 M
23	XOMA (US) LLC	California, United States	Medicine	Avg patent value: 7.15 M
24	Pfizer Inc.	New York, United States	Health care,Clinical trial,Drug, ...[+2]	Avg patent value: 7.08 M
25	FibroGen, Inc.	California, United States	Pharmacy and Therapeutics,CTGF,Idiopathic pulmonary fibrosis, ...[+2]	Avg patent value: 7.07 M
26	Gilead Sciences, Inc.	California, United States	Medicine,Health care,Biopharmaceutical, ...[+2]	Avg patent value: 7.04 M
27	Thrombogenics, Inc.	New York, United States	Biotechnology,Diabetic Eye Disease,Biopharmaceutical, ...[+2]	Avg patent value: 7.04 M
28	Chiron Corp.	California, United States	Blood testing,Biology,Drug discovery, ...[+2]	Avg patent value: 6.95 M
29	Gilead Calistoga LLC	California, United States	Clinical research	Avg patent value: 6.86 M
30	Zoetis Services LLC	New Jersey, United States	Drug,Medicine,Vertical farming, ...[+2]	Avg patent value: 6.74 M
31	Soligenix, Inc.	New Jersey, United States	Biodefense,Medicine,Health care, ...[+2]	Avg patent value: 6.62 M
32	Elan Pharmaceuticals, LLC	Michigan, United States	Autoimmune disease,Medicine,Enzyme, ...[+2]	Avg patent value: 6.53 M
33	Biothera, Inc.	Minnesota, United States	Biotechnology,Polysaccharide,Medical equipment, ...[+2]	Avg patent value: 6.29 M
34	AbbVie, Inc.	Illinois, United States	Health care,Medicine,Biopharmaceutical, ...[+2]	Avg patent value: 6.27 M
35	STARTUP Boston Pharmaceuticals, Inc.	Massachusetts, United States	Biotechnology,Drug development,Biopharmaceutical, ...[+2]	Avg patent value: 6.24 M
36	Regents of the University of California	California, United States	Working capital,Pathology,Companion diagnostic, ...[+2]	Avg patent value: 6.04 M
37	Pfizer Products, Inc.	Connecticut, United States		Avg patent value: 6.00 M
38	Theraclone Sciences, Inc.	Washington, United States	Monoclonal antibody,Health care,Pharmacy and Therapeutics, ...[+2]	Avg patent value: 5.88 M
39	Medarex, Inc.	New Jersey, United States	Pharmacy and Therapeutics,Medical equipment,Biopharmaceutical, ...[+2]	Avg patent value: 5.58 M
40	Vaccinex, Inc.	New York, United States	Antibody,Medicine,Health care, ...[+2]	Avg patent value: 5.57 M
41	Eisai, Inc.	New Jersey, United States	Health care,Medicine,Managed care, ...[+2]	Avg patent value: 5.51 M
42	Mereo Biopharma 5, Inc.	United States		Avg patent value: 5.48 M
43	Galaxy Biotech LLC	California, United States	Scientific literature,Biotechnology,Medicine, ...[+2]	Avg patent value: 5.47 M
44	Biogen MA, Inc.	Massachusetts, United States	Medicine,Drug,Developmental biology, ...[+2]	Avg patent value: 5.47 M
45	Inhibrx, Inc.	California, United States	Biotechnology,Protein engineering,Orphan diseases, ...[+2]	Avg patent value: 5.41 M
46	Bayer Healthcare LLC	New Jersey, United States	Pharmaceutical medicine,Medicine,Computed tomography, ...[+2]	Avg patent value: 5.33 M
47	Grifols Therapeutics, Inc.	North Carolina, United States	Congenital afibrinogenemia,Medicine,Fibrinogen, ...[+1]	Avg patent value: 5.32 M
48	Intrinsic Lifesciences LLC	California, United States	Medicine,Hepcidin,Biology, ...[+2]	Avg patent value: 5.26 M
49	Astellas Institute for Regenerative Medicine	Massachusetts, United States	Stem cell,Medicine,Health care, ...[+2]	Avg patent value: 5.25 M
50	EngMab SARL	California, United States	Biotechnology,Medicine,Cancer immunotherapy, ...[+2]	Avg patent value: 5.08 M
51	Merrimack Pharmaceuticals, Inc.	Massachusetts, United States	Health care,Autoimmunity,Medicine, ...[+2]	Avg patent value: 4.96 M
52	Deerfield Partners LP	New York, United States	Asset management,Impact investing	Avg patent value: 4.89 M
53	ImmunoGen, Inc.	Massachusetts, United States	Medicine,Health care,Pharmacy and Therapeutics, ...[+2]	Avg patent value: 4.86 M
54	Genentech, Inc.	California, United States	Biotechnology,Biology,Medicine, ...[+2]	Avg patent value: 4.84 M
55	EMD Millipore Corp.	Massachusetts, United States	Biotechnology,Biology,Medicine, ...[+2]	Avg patent value: 4.81 M
56	Stemcentrx, Inc.	California, United States	Cancer,Medicine,Pharmacy and Therapeutics, ...[+2]	Avg patent value: 4.76 M
57	Altrubio, Inc.	California, United States	E-commerce,Shopping mall,Immune checkpoint, ...[+2]	Avg patent value: 4.68 M
58	BioAtla, Inc.	California, United States	Health care,Monoclonal antibody,Drug, ...[+2]	Avg patent value: 4.66 M
59	Neogenix Oncology, Inc.	New York, United States	Oncology,Health care,Monoclonal antibody, ...[+2]	Avg patent value: 4.64 M
60	VentiRx Pharmaceuticals, Inc.	Washington, United States	Health care,Pharmacy and Therapeutics,TLR8, ...[+2]	Avg patent value: 4.63 M
61	Omeros Corp.	Washington, United States	Medicine,Health care,Central nervous system, ...[+2]	Avg patent value: 4.62 M
62	Mesoblast, Inc.	New York, United States	Orthopedic disorders,Drug,Medicine, ...[+2]	Avg patent value: 4.59 M
63	Argos Therapeutics, Inc.	North Carolina, United States	Immunotherapy,Medicine,Health care, ...[+2]	Avg patent value: 4.52 M
64	Amgen, Inc.	California, United States	Health care,Biopharmaceutical,TUMOR NECROSIS FACTOR BLOCKER, ...[+2]	Avg patent value: 4.45 M
65	Jounce Therapeutics, Inc.	Massachusetts, United States	Cancer immunotherapy,Immune system,Medicine, ...[+2]	Avg patent value: 4.45 M
66	Janssen Research & Development LLC	New Jersey, United States	Neuroscience,Oncology,Biotechnology, ...[+2]	Avg patent value: 4.43 M
67	Centocor Research & Development, Inc.	Pennsylvania, United States		Avg patent value: 4.43 M
68	Bristol Myers Squibb Co.	New York, United States	Medicine,Health care,Oncology drugs, ...[+2]	Avg patent value: 4.41 M
69	Bristol Myers Co.	New York, United States	Botanical drug,Herb	Avg patent value: 4.41 M
70	QIAGEN Sciences LLC	United States	Assay,Medicine,Sample preparation	Avg patent value: 4.39 M
71	AVEO Pharmaceuticals, Inc.	Massachusetts, United States	Biopharmaceutical,Medicine,Health care, ...[+2]	Avg patent value: 4.39 M
72	Purdue Pharma LP	Connecticut, United States	Opioid,Medicine,Opioid epidemic, ...[+2]	Avg patent value: 4.36 M
73	Purdue Pharma, Inc.	Connecticut, United States	Health care,Healthcare system,Educational program, ...[+1]	Avg patent value: 4.36 M
74	Incyte Corp.	Delaware, United States	Drug discovery,Medical equipment,Medicine, ...[+2]	Avg patent value: 4.32 M
75	STARTUP Forty Seven, Inc.	California, United States	Clinical trial,Medicine,Health care, ...[+2]	Avg patent value: 4.30 M
76	Lexicon Pharmaceuticals, Inc.	Texas, United States	Health care,Clinical trial,Medicine, ...[+2]	Avg patent value: 4.29 M
77	Roche Diagnostics Corp.	Indiana, United States	Medicine,Urinalysis,Immunoassay, ...[+2]	Avg patent value: 4.27 M
78	XBiotech, Inc.	Texas, United States	Health care,Biopharmaceutical,Antibody therapy, ...[+2]	Avg patent value: 4.23 M
79	OPKO Pharmaceuticals LLC	United States	Medicine	Avg patent value: 4.15 M
80	Inhibrx LP	California, United States	Antibody,Immune activation,Oncology, ...[+2]	Avg patent value: 4.14 M
81	Eli Lilly & Co.	Indiana, United States	Medicine,Health care,Humalog Mix, ...[+2]	Avg patent value: 3.97 M
82	eGen LLC	Connecticut, United States	STREAMS,Power transmission,Solar power, ...[+2]	Avg patent value: 3.96 M
83	Celsion Corp.	New Jersey, United States	Immunotherapy,Pharmacy and Therapeutics,Health care, ...[+2]	Avg patent value: 3.95 M
84	Apexigen America, Inc.	California, United States	Medicine,Health care,Antibody, ...[+2]	Avg patent value: 3.93 M
85	Aprecia Pharmaceuticals Co.	Pennsylvania, United States	Medicine,Peptide,Wafer, ...[+2]	Avg patent value: 3.89 M
86	Aprecia Pharmaceuticals LLC	Ohio, United States	Pharmaceutical manufacturing	Avg patent value: 3.89 M
87	Abgenix, Inc.	California, United States	Antibody,Pharmacy and Therapeutics,Lead compound, ...[+2]	Avg patent value: 3.73 M
88	Trellis RSV Holdings, Inc.	California, United States		Avg patent value: 3.67 M
89	Tarpon Biosystems, Inc.	Massachusetts, United States	Biomanufacturing,Health care,Bioreactor, ...[+2]	Avg patent value: 3.66 M
90	Emergent Product Development Seattle	Washington, United States	Autoimmune disease,Medicine,Health care, ...[+2]	Avg patent value: 3.63 M
91	Cell Signaling Technology, Inc.	Massachusetts, United States	Cell signaling,Medical equipment,Cell, ...[+2]	Avg patent value: 3.56 M
92	Genzyme Corp.	Massachusetts, United States	Medicine,Pharmacy and Therapeutics,Multiple sclerosis, ...[+2]	Avg patent value: 3.52 M
93	MacroGenics, Inc.	United States	Monoclonal antibody,Medicine,Health care, ...[+2]	Avg patent value: 3.43 M
94	C2N Diagnostics LLC	Missouri, United States	Mass spectrometry,Amyloid beta,Stable Isotope Labeling, ...[+2]	Avg patent value: 3.42 M
95	Rinat Neuroscience Corp.	California, United States	Neuroscience,Antibody,Medicine, ...[+2]	Avg patent value: 3.38 M
96	Novavax, Inc.	United States	ISCOM,Medicine,Health care, ...[+2]	Avg patent value: 3.37 M
97	KellBenx, Inc.	New York, United States	Prenatal diagnosis,Medicine,Health care, ...[+2]	Avg patent value: 3.26 M
98	STARTUP Precision Biologics, Inc.	Texas, United States	Cancer vaccine,Pharmacy and Therapeutics,Biotechnology, ...[+2]	Avg patent value: 3.15 M
99	Acorda Therapeutics, Inc.	New York, United States	Software development,Health care,Inhaler, ...[+2]	Avg patent value: 3.14 M
100	Attenuon, LLC	California, United States		Avg patent value: 3.13 M