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Top 100 Key Players companies in Phenotype
by Highest Patent Value in the United States in 2018

The Phenotype top 100 is Discovery PatSnap’ annual ranking of the top 100 Highest Patent Value Phenotype Key Players in the United States. Discovery has identified the top key players, startups & unicorns, fast-growings, news entrants in 2018, ranking from differnt perspectives, including patent filing intensity, academic research capability, news media heat. The company list is generated from various data types.
In genetics, the phenotype (from Greek phainein, meaning 'to show', and typos, meaning 'type') of an organism is the composite of the organism's observable characteristics or traits. The term covers the organism's morphology or physical form and structure, its developmental processes, its biochemical and physiological properties, its behavior, and the products of behavior. An organism's phenotype results from two basic factors: the expression of an organism's genetic code, or its genotype, and the influence of environmental factors. Both factors may interact, further affecting phenotype. When two or more clearly different phenotypes exist in the same population of a species, the species is called polymorphic. A well-documented example of polymorphism is Labrador Retriever coloring; while the coat color depends on many genes, it is clearly seen in the environment as yellow, black, and brown. Richard Dawkins in 1978 and then again in his 1982 book The Extended Phenotype suggested that one can regard bird nests and other built structures such as caddis-fly larvae cases and beaver dams as "extended phenotypes".
#
Company Name
Region
Tech Topics
Total
1
DePuy Synthes Products, Inc.
Medical equipment,Medicine,Pressure sensor,
...[+2]
Avg patent value: 9.64 M
2
Astellas Institute for Regenerative Medicine
Stem cell,Medicine,Health care,
...[+2]
Avg patent value: 9.20 M
3
ViaCyte, Inc.
Stem cell,Diabetes Therapy,Medicine,
...[+2]
Avg patent value: 8.49 M
4
Mesoblast, Inc.
Orthopedic disorders,Drug,Medicine,
...[+2]
Avg patent value: 8.41 M
5
Anthrogenesis Corp.
Stem cell,Pharmacy and Therapeutics,Placenta,
...[+2]
Avg patent value: 7.99 M
6
Pharmacyclics LLC
Medicine,Drug,Oncology drugs,
...[+2]
Avg patent value: 7.10 M
7
Geron Corp.
Medicine,Telomerase Inhibitor,Imetelstat,
...[+2]
Avg patent value: 6.97 M
8
X-Body, Inc.
Software development,Pharmacy and Therapeutics,Wilms Tumor Protein,
...[+2]
Avg patent value: 6.30 M
9
Infinity Discovery, Inc.
Avg patent value: 6.18 M
10
Virginia Tech Intellectual Properties, Inc.
Software,Medical imaging,Digital library,
...[+2]
Avg patent value: 5.93 M
11
Ethicon Endo-Surgery, Inc.
Medicine,Medical equipment,Mammotome,
...[+2]
Avg patent value: 5.69 M
12
Infinity Pharmaceuticals, Inc.
Medicine,Clinical trial,Hsp90,
...[+2]
Avg patent value: 5.50 M
13
Danisco US, Inc.
Synthetic rubber,Bioplastic,Plasticizer,
...[+2]
Avg patent value: 5.47 M
14
Applied Biosystems LLC
Consumables,Genetic analysis,Software,
...[+2]
Avg patent value: 5.12 M
15
Genzyme Corp.
Medicine,Pharmacy and Therapeutics,Multiple sclerosis,
...[+2]
Avg patent value: 5.04 M
16
Vericel Corp.
Cell therapy,Biology,Medicine,
...[+2]
Avg patent value: 5.04 M
17
Iovance Biotherapeutics, Inc.
Metastatic melanoma,Medicine,Health care,
...[+2]
Avg patent value: 4.73 M
18
United Therapeutics Corp.
Medicine,Pharmacy and Therapeutics,Biotechnology,
...[+2]
Avg patent value: 4.47 M
19
Iontas, Inc.
Software,Resource management,Enterprise software,
...[+2]
Avg patent value: 4.43 M
20
BioConsortia, Inc.
Plant breeding,Agriculture,Farming industry,
...[+2]
Avg patent value: 4.18 M
21
CP Kelco US, Inc.
Pectin,Carrageenan,Food processing,
...[+2]
Avg patent value: 4.17 M
22
Zoetis Services LLC
Drug,Medicine,Vertical farming,
...[+2]
Avg patent value: 4.09 M
23
Cota, Inc.
Precision medicine,Biology,Health care,
...[+2]
Avg patent value: 3.95 M
24
Edimer Pharmaceuticals, Inc.
Biology,Medicine,Health care,
...[+2]
Avg patent value: 3.89 M
25
Sanofi Pasteur Biologics LLC
Medicine
Avg patent value: 3.87 M
26
Regents of the University of California
Working capital,Pathology,Companion diagnostic,
...[+2]
Avg patent value: 3.72 M
27
Q Therapeutics, Inc.
Medicine,Health care,Pharmacy and Therapeutics,
...[+2]
Avg patent value: 3.71 M
28
Fluoresentric, Inc.
Molecular diagnostics,Assay,Polymerase chain reaction
Avg patent value: 3.63 M
29
Quorum Innovations LLC
Probiotic,Microbiome,Medicine,
...[+2]
Avg patent value: 3.39 M
30
Roche Diagnostics Corp.
Medicine,Urinalysis,Immunoassay,
...[+2]
Avg patent value: 3.33 M
31
Regeneron Pharmaceuticals, Inc.
Monoclonal antibody,Clinical trial,Cholesterol,
...[+2]
Avg patent value: 3.22 M
32
NatureWorks LLC
Biopolymer,Chemical engineering,Natural resource management,
...[+2]
Avg patent value: 3.16 M
33
Factor Bioscience, Inc.
Regenerative medicine,Cell,Somatic cell,
...[+1]
Avg patent value: 3.09 M
34
Viridos, Inc.
Synthetic genomics,Health care,Synthetic biology,
...[+2]
Avg patent value: 3.05 M
35
Inovio Pharmaceuticals, Inc.
Medicine,Health care,Pharmacy and Therapeutics,
...[+2]
Avg patent value: 2.95 M
36
Accelerated Biosciences Corp.
Regenerative medicine
Avg patent value: 2.78 M
37
23andMe, Inc.
Human genome,Genealogy,Genetic testing,
...[+2]
Avg patent value: 2.69 M
38
Natera, Inc.
Genetic diagnosis,Health care,Genetic testing,
...[+2]
Avg patent value: 2.69 M
39
Roche Molecular Systems, Inc.
Health care,Blood Screening,Polymerase chain reaction,
...[+2]
Avg patent value: 2.66 M
40
FlowJo LLC
Biotechnology,Flow cytometry,Exosome,
...[+2]
Avg patent value: 2.60 M
41
DowElanco Ltd.
Chemical engineering,Agriculture,Pest control
Avg patent value: 2.48 M
42
Biora Therapeutics, Inc.
Health care,Genomics,Neonatology,
...[+2]
Avg patent value: 2.47 M
43
Monsanto Technology LLC
Avg patent value: 2.38 M
44
Pioneer Hi-Bred International, Inc.
Avg patent value: 2.30 M
45
Sangamo Therapeutics, Inc.
Cell,Pharmacy and Therapeutics,Genomics,
...[+2]
Avg patent value: 2.28 M
46
Merck & Co., Inc.
Health care,Biopharmaceutical,Drug,
...[+2]
Avg patent value: 2.24 M
47
Genentech, Inc.
Biotechnology,Biology,Medicine,
...[+2]
Avg patent value: 2.20 M
48
Philips RS North America LLC
Avg patent value: 2.11 M
49
RIC Investments LLC
National security,Aerospace
Avg patent value: 2.11 M
50
Merck Sharp & Dohme Corp.
Prescription drug,Medicine,Stroke,
...[+2]
Avg patent value: 2.02 M
51
U.S. Smokeless Tobacco Co. LLC
Smokeless tobacco,Nicotiana tabacum,Chewing tobacco,
...[+2]
Avg patent value: 2.00 M
52
Philip Morris USA, Inc.
Smokeless tobacco,Petroleum industry,Chemical engineering,
...[+2]
Avg patent value: 1.97 M
53
BioArray Solutions Ltd.
Pharmacy,Medicine,Transplantation medicine,
...[+2]
Avg patent value: 1.82 M
54
E.I. du Pont de Nemours & Co.
Agriculture,Materials science,Electronics,
...[+2]
Avg patent value: 1.78 M
55
BASF Plant Science LLC
Starch,Fertilizer,Plant science
Avg patent value: 1.77 M
56
Bell Biosystems, Inc.
Cell encapsulation,Clinical trial,Pharmacy and Therapeutics,
...[+2]
Avg patent value: 1.65 M
57
Capia IP LLC
Avg patent value: 1.61 M
58
Ventana Medical Systems, Inc.
Medical equipment,Health care,Digital pathology,
...[+2]
Avg patent value: 1.53 M
59
Geneus Health LLC
Health care
Avg patent value: 1.32 M
60
New England Biolabs, Inc.
RNA,Biology,Health care,
...[+2]
Avg patent value: 1.25 M
61
Progyny, Inc.
Fertility,Health care,Male infertility,
...[+2]
Avg patent value: 1.21 M
62
Genomatica, Inc.
Chemical engineering,Medicine,Renewable energy,
...[+2]
Avg patent value: 1.18 M
63
Pacific Biosciences of California, Inc.
Industrial engineering,Biology,Health care,
...[+2]
Avg patent value: 1.15 M
64
Blue River Technology, Inc.
Robotics,Agriculture,Robot,
...[+2]
Avg patent value: 1.13 M
65
Molecular Devices LLC
High-throughput screening,Biological system,Laboratory automation,
...[+2]
Avg patent value: 1.11 M
66
International Business Machines Corp.
Software,Computer hardware,Enterprise software,
...[+2]
Avg patent value: 1.05 M
67
Shire Human Genetic Therapies, Inc.
Medicine
Avg patent value: 1.05 M
68
Boehringer Ingelheim Pharmaceuticals, Inc.
Central nervous system,Medicine,Drug,
...[+2]
Avg patent value: 1.00 M
69
Hi Fidelity Genetics, Inc.
Computer hardware,Data processing
Avg patent value: 996,500
70
Avera Pharmaceuticals, Inc.
Health care,Gantacurium,Endotracheal intubation,
...[+2]
Avg patent value: 990,000
71
Abela Pharmaceuticals, Inc.
Avg patent value: 990,000
72
Merlogen LLC
Avg patent value: 950,000
73
Okogen, Inc.
Viral Conjunctivitis,Ribonuclease,Health care,
...[+2]
Avg patent value: 910,000
74
Enzo Biochem, Inc.
Drug development,Clinical research,Coronavirus,
...[+2]
Avg patent value: 900,000
75
MiMedx Group, Inc.
Medical equipment,Wellness Programs,Health care,
...[+2]
Avg patent value: 900,000
76
BioCardia, Inc.
Medicine,Regenerative medicine,Health care,
...[+2]
Avg patent value: 870,000
77
iRepertoire, Inc.
Immune repertoire,Data processing,Health care,
...[+2]
Avg patent value: 870,000
78
Caris Life Sciences, LLC
Health care,Precision medicine,Biotechnology,
...[+2]
Avg patent value: 860,000
79
Caris Life Sciences, Inc.
Biotechnology,Agriculture,Fishery,
...[+2]
Avg patent value: 860,000
80
ISTO Technologies, Inc.
Cartilage,Medical equipment,Cell therapy,
...[+2]
Avg patent value: 850,000
81
Life Technologies Clinical Services Lab, Inc.
Genetic testing,Health care,Genotype,
...[+2]
Avg patent value: 847,500
82
Agrivida, Inc.
Agricultural biotechnology,Alternative fuels,Ethanol,
...[+2]
Avg patent value: 839,500
83
enEvolv, Inc.
Agriculture,Microorganism,Genome engineering,
...[+2]
Avg patent value: 780,000
84
MPEG LA LLC
Alternative technology,Chemical engineering,Patent pool,
...[+2]
Avg patent value: 730,000
85
Biomet Biologics LLC
Biotechnology,Medicine
Avg patent value: 730,000
86
Biomet Manufacturing LLC
Bone healing,Medical equipment,Medicine,
...[+1]
Avg patent value: 730,000
87
Asterias Biotherapeutics, Inc.
Biology,Medicine,Pharmacy and Therapeutics,
...[+2]
Avg patent value: 714,466
88
Gevo, Inc.
Biofuel,Fossil fuel,Petrochemical,
...[+2]
Avg patent value: 710,000
89
Zimmer, Inc.
Joint replacement,Medicine,Medical equipment,
...[+1]
Avg patent value: 670,000
90
PureCircle USA, Inc.
Food industry,Snack foods,High-fructose corn syrup,
...[+2]
Avg patent value: 584,000
91
Targeted Growth, Inc.
Agriculture,Energy crop,Pesticide,
...[+2]
Avg patent value: 580,000
92
Celmatix, Inc.
Fertility,Medicine,Health care,
...[+2]
Avg patent value: 578,000
93
Seminis Vegetable Seeds, Inc.
Plant breeding,Agriculture,Crop
Avg patent value: 552,518
94
Athersys, Inc.
Health care,Clinical trial,Stem cell,
...[+2]
Avg patent value: 530,000
95
Zymergen, Inc.
Robotics,Machine learning,Molecule,
...[+2]
Avg patent value: 511,205
96
Celavie Biosciences LLC
Avg patent value: 460,000
97
BASF Agricultural Solutions Seed US LLC
Chemical engineering
Avg patent value: 431,760
98
IROA Technologies LLC
Chemical signature,Petrochemical,Biology,
...[+2]
Avg patent value: 431,600
99
Exelixis Plant Sciences, Inc.
Pesticide,Gene,DNA,
...[+1]
Avg patent value: 420,000
100
Intrinsic BioProbes, Inc.
Biotechnology,Mass spectrometry
Avg patent value: 410,000
Page generation time: Apr 29 2025