Top 100 Key Players companies in Proline by Highest Patent Value in the world in 2022 – Discovery

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The Proline top 100 is Discovery PatSnap’ annual ranking of the top 100 Highest Patent Value Proline Key Players in the world. Discovery has identified the top key players, startups & unicorns, fast-growings, news entrants in 2022, ranking from differnt perspectives, including patent filing intensity, academic research capability, news media heat. The company list is generated from various data types.

Proline (symbol Pro or P) is a proteinogenic amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated NH₂⁺ form under biological conditions), an α-carboxylic acid group (which is in the deprotonated −COO⁻ form under biological conditions), and a side chain pyrrolidine, classifying it as a nonpolar (at physiological pH), aliphatic amino acid. It is non-essential in humans, meaning the body can synthesize it from the non-essential amino acid L-glutamate. It is encoded by all the codons starting CC (CCU, CCC, CCA, and CCG).

1	ArQule, Inc.	Massachusetts, United States	Pharmacy and Therapeutics,Biotechnology,Oncology drugs, ...[+2]	Avg patent value: 10.54 M
2	Kirin-Amgen, Inc.	California, United States	Pharmaceutical drug,Medicine	Avg patent value: 10.17 M
3	PPG Industries, Inc.	Pennsylvania, United States	Coating,Chemical engineering,Industrial engineering, ...[+2]	Avg patent value: 9.69 M
4	PPG Industries Ohio, Inc.	Ohio, United States	Coating,Industrial engineering,Metal fiber, ...[+2]	Avg patent value: 9.69 M
5	Seagen Inc.	Washington, United States	Antibody-drug conjugate,Medicine,Health care, ...[+2]	Avg patent value: 9.59 M
6	Dong-A ST Co., Ltd.	South Korea	Medicine,Mucous membrane,Growth hormone, ...[+2]	Avg patent value: 8.97 M
7	Ablynx NV	Oost-Vlaanderen, Belgium	Medicine,Single-domain antibody,Therapeutic protein, ...[+2]	Avg patent value: 8.80 M
8	STARTUP Viela Bio, Inc.	United States	B cell,Immunotherapy,Biotechnology, ...[+2]	Avg patent value: 8.71 M
9	GlobeImmune, Inc.	Colorado, United States	Cancer,Medicine,Health care, ...[+2]	Avg patent value: 8.49 M
10	Promega Corp.	Wisconsin, United States	Enzyme,Journalism,Biology, ...[+2]	Avg patent value: 8.39 M
11	Alkermes, Inc.	DUBLIN, Ireland	Medicine,Health care,Liposome, ...[+2]	Avg patent value: 8.08 M
12	Genmab A/S	Hovedstaden, Denmark	Health care,Antibody,Biotechnology, ...[+2]	Avg patent value: 7.92 M
13	Genmab BV	Netherlands		Avg patent value: 7.92 M
14	Enanta Pharmaceuticals, Inc.	Massachusetts, United States	Medicine,Health care,Protease, ...[+2]	Avg patent value: 7.91 M
15	BioArctic AB	Sweden	Health care,Medicine,Mutation, ...[+2]	Avg patent value: 7.84 M
16	Arcellx, Inc.	United States	Medicine,Cell therapy,Cell, ...[+2]	Avg patent value: 7.64 M
17	Novo Nordisk A/S	Hovedstaden, Denmark	Insulin,Health care,Haemophilia, ...[+2]	Avg patent value: 7.57 M
18	Hanmi Science Co., Ltd.	South Korea	Clinical trial,Medicine,Drug repositioning, ...[+2]	Avg patent value: 7.51 M
19	AC Immune SA	Vaud, Switzerland	Pharmacy and Therapeutics,Medicine,Biomedicine, ...[+2]	Avg patent value: 7.19 M
20	Regeneron Pharmaceuticals, Inc.	New York, United States	Monoclonal antibody,Clinical trial,Cholesterol, ...[+2]	Avg patent value: 7.15 M
21	Janssen Pharmaceutica NV	Antwerpen, Belgium	Product design,Neuroscience,Health care, ...[+2]	Avg patent value: 7.07 M
22	Roche Glycart AG	Zürich, Switzerland	Antibody,Medicine,Health care, ...[+2]	Avg patent value: 6.86 M
23	GlaxoSmithKline Biologicals SA	Belgium	Medicine,Rubella,Hepatitis, ...[+2]	Avg patent value: 6.53 M
24	Asahi Kasei Corp.	Tokyo, Japan	Chemical engineering,Petrochemical,Fertilizer, ...[+2]	Avg patent value: 6.18 M
25	Idorsia Ltd.	Basel-Landschaft, Switzerland	Medicine,Health care,Cerebral vasospasm, ...[+2]	Avg patent value: 6.18 M
26	Asahi Kasei Pharma Corp.	Tokyo, Japan	Diagnostic Reagent,Transdermal patch,Medicine, ...[+2]	Avg patent value: 6.18 M
27	Idorsia Pharmaceuticals Ltd.	Switzerland	Herb,Botanical drug	Avg patent value: 6.18 M
28	AFFiRiS AG	Niederösterreich, Austria	Medicine,Health care,Peptide, ...[+2]	Avg patent value: 6.17 M
29	CARA Therapeutics, Inc.	Connecticut, United States	Analgesic,Medicine,Health care, ...[+2]	Avg patent value: 6.15 M
30	Nutricia NV	Zuid-Holland, Netherlands	Food industry	Avg patent value: 6.13 M
31	Janssen Global Services LLC	California, United States	Medicine,Pharmacy and Therapeutics,Viral disease, ...[+2]	Avg patent value: 6.08 M
32	Janssen BioPharma LLC	California, United States		Avg patent value: 6.08 M
33	Novartis AG	Basel-Stadt, Switzerland	Dosage form,Health care,Medicine, ...[+2]	Avg patent value: 6.00 M
34	Chugai Pharmaceutical Co., Ltd.	Tokyo, Japan	Drug,Clinical trial,Health care, ...[+2]	Avg patent value: 5.96 M
35	DePuy Synthes Products, Inc.	Delaware, United States	Medical equipment,Medicine,Pressure sensor, ...[+2]	Avg patent value: 5.82 M
36	CSL Ltd.	New South Wales, Australia	Health care,Clinical trial,Influenza vaccine, ...[+2]	Avg patent value: 5.81 M
37	Helix BioMedix, Inc.	Washington, United States	Peptide,Medical equipment,Medicine, ...[+2]	Avg patent value: 5.77 M
38	NovaBiotics Ltd.	Aberdeen City, United Kingdom	Pharmacy and Therapeutics,Medicine,Health care, ...[+2]	Avg patent value: 5.76 M
39	CureVac AG	Baden-Württemberg, Germany	Messenger RNA,Medicine,Pharmacy and Therapeutics, ...[+2]	Avg patent value: 5.72 M
40	STARTUP GlyTech, Inc.	Tokyo, Japan	Clinical trial,Drug discovery,Medicine, ...[+1]	Avg patent value: 5.53 M
41	RECORDATI AG	Zug, Switzerland	Health care	Avg patent value: 5.45 M
42	Syngenta AG	Basel-Stadt, Switzerland	Pesticide,Agriculture,Farming industry, ...[+2]	Avg patent value: 5.44 M
43	Syngenta Participations AG	Switzerland		Avg patent value: 5.44 M
44	Kyowa Kirin Co., Ltd.	Tokyo, Japan	Health care,Drug,Medicine, ...[+2]	Avg patent value: 5.43 M
45	AstraZeneca Plc	Cambridgeshire, United Kingdom	Medicine,Health care,Side effect, ...[+2]	Avg patent value: 5.33 M
46	AstraZeneca UK Ltd.	Cambridgeshire, United Kingdom	Gastrointestinal infections,Medicine,Simvastatin, ...[+2]	Avg patent value: 5.33 M
47	Gilead Sciences, Inc.	California, United States	Medicine,Health care,Biopharmaceutical, ...[+2]	Avg patent value: 5.32 M
48	Bestewil Holding BV	Netherlands	Medicine	Avg patent value: 5.17 M
49	Wyeth LLC	New Jersey, United States		Avg patent value: 4.86 M
50	Soligenix, Inc.	New Jersey, United States	Biodefense,Medicine,Health care, ...[+2]	Avg patent value: 4.86 M
51	Terumo Corp.	Tokyo, Japan	Health care,Blood management,Syringe, ...[+2]	Avg patent value: 4.81 M
52	Genentech, Inc.	California, United States	Biotechnology,Biology,Medicine, ...[+2]	Avg patent value: 4.73 M
53	Sichuan Haisco Pharmaceutical Co., Ltd.	Sichuan Sheng, China		Avg patent value: 4.71 M
54	Sarepta Therapeutics, Inc.	Massachusetts, United States	Pharmacy and Therapeutics,Health care,Approved drug, ...[+2]	Avg patent value: 4.62 M
55	Amunix Pharmaceuticals, Inc.	California, United States	Half-life,Conjugate,Medicine, ...[+2]	Avg patent value: 4.62 M
56	The Dow Chemical Co.	Michigan, United States	Coating,Agriculture,Chemical engineering, ...[+2]	Avg patent value: 4.55 M
57	Valneva Austria GmbH	Austria	Biotechnology,Nanotechnology,Biology, ...[+2]	Avg patent value: 4.52 M
58	F. Hoffmann-La Roche Ltd.	Switzerland	Medicine,Health care,Drug, ...[+2]	Avg patent value: 4.33 M
59	Bayer CropScience NV	Belgium	Agrochemical	Avg patent value: 4.31 M
60	XL-protein GmbH	Bayern, Germany	Medicine,Biopharmaceutical,Drug development, ...[+2]	Avg patent value: 4.31 M
61	Los Alamos National Security LLC	New Mexico, United States	National security	Avg patent value: 4.30 M
62	Idemitsu Kosan Co., Ltd.	Tokyo, Japan	Petrochemical,Lubricant,Petroleum, ...[+2]	Avg patent value: 4.27 M
63	Glaxo Group Ltd.	Hounslow, United Kingdom	Food products,Medicine,Health care	Avg patent value: 4.20 M
64	Haemostatix Ltd.	Nottingham, United Kingdom	Hemostat,Hemostatic Agent,Health care, ...[+2]	Avg patent value: 4.19 M
65	GlaxoSmithKline Intellectual Property (No. 2) Ltd.	United Kingdom	Intellectual property	Avg patent value: 4.16 M
66	Shijiazhuang Yiling Pharmaceutical Co., Ltd.	Hebei Sheng, China	Health care,Medicine,Drug, ...[+2]	Avg patent value: 4.13 M
67	FUJIFILM Wako Pure Chemical Corp.	Osaka, Japan	Diagnostic Reagent,Laboratory chemicals	Avg patent value: 4.09 M
68	Abbott Molecular, Inc.	Illinois, United States	Medical equipment,Health care,Molecular diagnostics, ...[+2]	Avg patent value: 4.03 M
69	ethris GmbH	Bayern, Germany	Inhaler,Messenger RNA,Therapeutic protein, ...[+2]	Avg patent value: 3.97 M
70	Biotec Co. Ltd.	Japan	Washer,Automation,Manufacturing engineering, ...[+2]	Avg patent value: 3.94 M
71	Bayer Intellectual Property GmbH	Nordrhein-Westfalen, Germany		Avg patent value: 3.93 M
72	Aventis Animal Nutrition SA	Île-de-France, France	Feed additive,Agriculture,Animal nutrition, ...[+1]	Avg patent value: 3.91 M
73	Medimmune, Inc.	United States	Botanical drug,Herb	Avg patent value: 3.81 M
74	Cellivery Therapeutics, Inc.	South Korea	Enzyme,Health care,Pharmacy and Therapeutics, ...[+2]	Avg patent value: 3.79 M
75	B·R·A·H·M·S GmbH	Brandenburg, Germany	Molecular diagnostics,Diagnostic test,Medicine, ...[+2]	Avg patent value: 3.79 M
76	Galen Bio, Inc.	United States		Avg patent value: 3.79 M
77	Eneos Corp.	Tokyo, Japan	Petroleum,Lubricant,Petroleum industry, ...[+2]	Avg patent value: 3.67 M
78	Spexis Ltd.	Basel-Landschaft, Switzerland	Health care,Antibiotic resistance,Pseudomonas infection, ...[+2]	Avg patent value: 3.66 M
79	Altrubio, Inc.	California, United States	E-commerce,Shopping mall,Immune checkpoint, ...[+2]	Avg patent value: 3.64 M
80	Triad National Security LLC	Ohio, United States		Avg patent value: 3.53 M
81	Daiwa Pharmaceutical Co., Ltd.	Toyama, Japan		Avg patent value: 3.46 M
82	Amgen, Inc.	California, United States	Health care,Biopharmaceutical,TUMOR NECROSIS FACTOR BLOCKER, ...[+2]	Avg patent value: 3.44 M
83	Mitsubishi Tanabe Pharma Corp.	Osaka, Japan	Medicine,Health care,Toxoid, ...[+2]	Avg patent value: 3.44 M
84	Ares Trading SA	Switzerland		Avg patent value: 3.40 M
85	Amgen Research (Munich) GmbH	Hessen, Germany	Metal powder,Metal	Avg patent value: 3.37 M
86	CSL Behring GmbH	Hessen, Germany	Medicine	Avg patent value: 3.36 M
87	Galaxy Surfactants Ltd.	Maharashtra, India	Chemical engineering,Silicone,Plasticizer, ...[+2]	Avg patent value: 3.29 M
88	Shin-Etsu Chemical Co., Ltd.	Tokyo, Japan	Silicone,Semiconductor,Chemical engineering, ...[+2]	Avg patent value: 3.23 M
89	Alteogen, Inc.	South Korea	Antibody-drug conjugate,Medicine,Biosimilar, ...[+2]	Avg patent value: 3.21 M
90	Evonik Degussa Japan Co., Ltd.	Tokyo, Japan		Avg patent value: 3.17 M
91	Nihon Koshuha Co. Ltd.	Japan		Avg patent value: 3.12 M
92	Colgate-Palmolive Co.	New York, United States	Toothpaste,Dental floss,Fast-moving consumer goods, ...[+2]	Avg patent value: 3.09 M
93	Colgate-Palmolive A/S	Denmark	Toothbrush,Toothpaste,SOAP, ...[+1]	Avg patent value: 3.09 M
94	Teijin Ltd.	Tokyo, Japan	Synthetic rubber,Chemical engineering,Polycarbonate, ...[+2]	Avg patent value: 3.05 M
95	Cambrex IEP GmbH	Hessen, Germany	Epoxide,Chemical engineering,Enzyme	Avg patent value: 3.04 M
96	Purdue Pharma LP	Connecticut, United States	Opioid,Medicine,Opioid epidemic, ...[+2]	Avg patent value: 3.02 M
97	Purdue Pharma, Inc.	Connecticut, United States	Health care,Healthcare system,Educational program, ...[+1]	Avg patent value: 3.02 M
98	Daewoong Pharmaceutical Co., Ltd.	South Korea	Global health,Medicine,Over-the-counter, ...[+2]	Avg patent value: 3.00 M
99	Riken Corp.	Saitama, Japan	Social network,Tappet,Piston ring, ...[+2]	Avg patent value: 2.93 M
100	DuPont Nutrition Biosciences ApS	Hovedstaden, Denmark	Food science,Medicine,Health care, ...[+2]	Avg patent value: 2.93 M