Top 100 Key Players companies in Proline by Highest Patent Value in the Japan in 2021 – Discovery

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The Proline top 100 is Discovery PatSnap’ annual ranking of the top 100 Highest Patent Value Proline Key Players in the Japan. Discovery has identified the top key players, startups & unicorns, fast-growings, news entrants in 2021, ranking from differnt perspectives, including patent filing intensity, academic research capability, news media heat. The company list is generated from various data types.

Proline (symbol Pro or P) is a proteinogenic amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated NH₂⁺ form under biological conditions), an α-carboxylic acid group (which is in the deprotonated −COO⁻ form under biological conditions), and a side chain pyrrolidine, classifying it as a nonpolar (at physiological pH), aliphatic amino acid. It is non-essential in humans, meaning the body can synthesize it from the non-essential amino acid L-glutamate. It is encoded by all the codons starting CC (CCU, CCC, CCA, and CCG).

1	Asahi Kasei Corp.	Tokyo, Japan	Chemical engineering,Petrochemical,Fertilizer, ...[+2]	Avg patent value: 6.18 M
2	Asahi Kasei Pharma Corp.	Tokyo, Japan	Diagnostic Reagent,Transdermal patch,Medicine, ...[+2]	Avg patent value: 6.18 M
3	Chugai Pharmaceutical Co., Ltd.	Tokyo, Japan	Drug,Clinical trial,Health care, ...[+2]	Avg patent value: 5.96 M
4	STARTUP GlyTech, Inc.	Tokyo, Japan	Clinical trial,Drug discovery,Medicine, ...[+1]	Avg patent value: 5.53 M
5	Kyowa Kirin Co., Ltd.	Tokyo, Japan	Health care,Drug,Medicine, ...[+2]	Avg patent value: 5.43 M
6	Terumo Corp.	Tokyo, Japan	Health care,Blood management,Syringe, ...[+2]	Avg patent value: 4.81 M
7	Idemitsu Kosan Co., Ltd.	Tokyo, Japan	Petrochemical,Lubricant,Petroleum, ...[+2]	Avg patent value: 4.27 M
8	FUJIFILM Wako Pure Chemical Corp.	Osaka, Japan	Diagnostic Reagent,Laboratory chemicals	Avg patent value: 4.09 M
9	Biotec Co. Ltd.	Japan	Washer,Automation,Manufacturing engineering, ...[+2]	Avg patent value: 3.94 M
10	Eneos Corp.	Tokyo, Japan	Petroleum,Lubricant,Petroleum industry, ...[+2]	Avg patent value: 3.67 M
11	Daiwa Pharmaceutical Co., Ltd.	Toyama, Japan		Avg patent value: 3.46 M
12	Mitsubishi Tanabe Pharma Corp.	Osaka, Japan	Medicine,Health care,Toxoid, ...[+2]	Avg patent value: 3.44 M
13	Shin-Etsu Chemical Co., Ltd.	Tokyo, Japan	Silicone,Semiconductor,Chemical engineering, ...[+2]	Avg patent value: 3.23 M
14	Evonik Degussa Japan Co., Ltd.	Tokyo, Japan		Avg patent value: 3.17 M
15	Nihon Koshuha Co. Ltd.	Japan		Avg patent value: 3.12 M
16	Teijin Ltd.	Tokyo, Japan	Synthetic rubber,Chemical engineering,Polycarbonate, ...[+2]	Avg patent value: 3.05 M
17	Riken Corp.	Saitama, Japan	Social network,Tappet,Piston ring, ...[+2]	Avg patent value: 2.93 M
18	JCR Pharmaceuticals Co., Ltd.	Hokkaido, Japan	Raw material,Drug,Medicine, ...[+2]	Avg patent value: 2.71 M
19	Eisai R&D Management Co., Ltd.	Tokyo, Japan	Biotechnology,Agriculture,Fishery, ...[+2]	Avg patent value: 2.69 M
20	Kyowa Hakko Kogyo Co., Ltd.	Tokyo, Japan	Fertilizer,Agrochemical,Raw material, ...[+2]	Avg patent value: 2.45 M
21	Japan Tobacco, Inc.	Tokyo, Japan	Nicotiana tabacum,Cigarillo,Food sector, ...[+2]	Avg patent value: 2.42 M
22	Teijin Pharma Ltd.	Tokyo, Japan	Medical equipment,Respiratory disease,Oxygen concentrator, ...[+2]	Avg patent value: 2.04 M
23	Ajinomoto Co., Inc.	Tokyo, Japan	Seasoning,Amino acid,Food processing, ...[+2]	Avg patent value: 1.84 M
24	Takeuchi Co. Ltd.	Japan	Automation,Manufacturing engineering,Industrial engineering, ...[+2]	Avg patent value: 1.76 M
25	BONAC Corp.	Fukuoka, Japan	Nucleic acid,Medicine,Chemical engineering, ...[+2]	Avg patent value: 1.58 M
26	The Chemo-Sero-Therapeutic Research Institute	Kumamoto, Japan	Blood plasma,Medicine,Suture (anatomy), ...[+2]	Avg patent value: 1.54 M
27	ARKRAY, Inc.	Kyoto, Japan	Functional food,Blood glucose monitoring,Medical equipment, ...[+2]	Avg patent value: 1.50 M
28	Multi & Relational System Co., Ltd.	Niigata, Japan	Web development	Avg patent value: 1.49 M
29	Shiseido Co., Ltd.	Tokyo, Japan	Cosmetics,Elixir,Personal Care Product, ...[+2]	Avg patent value: 1.42 M
30	Amano Enzyme, Inc.	Nagano, Japan	Enzyme,Drug,Chemical engineering, ...[+2]	Avg patent value: 1.36 M
31	Astellas Pharma, Inc.	Tokyo, Japan	Health care,Clinical trial,Diabetic complication, ...[+2]	Avg patent value: 1.34 M
32	Toray Industries, Inc.	Tokyo, Japan	Fiber,Textile,Textile (markup language), ...[+2]	Avg patent value: 1.09 M
33	Kirin Food-Tech Co., Ltd.	Tokyo, Japan	Petrochemical,Benzene,Petroleum, ...[+2]	Avg patent value: 1.00 M
34	Hamari Chemicals Ltd.	Osaka, Japan	Medicine,Glycoside,Amino acid derivative, ...[+2]	Avg patent value: 920,000
35	Meiji Co., Ltd.	Tokyo, Japan	Food industry,Snack foods,Hard candy, ...[+2]	Avg patent value: 887,500
36	Meiji Seika Kaisha Ltd.	Tokyo, Japan	Veterinary medicine,Food industry,Snack foods, ...[+1]	Avg patent value: 877,500
37	Meiji Seika Pharma Co., Ltd.	Tokyo, Japan	Clinical trial,Drug,Medicine, ...[+2]	Avg patent value: 877,500
38	Morinaga Milk Industry Co., Ltd.	Tokyo, Japan	Probiotic,Food industry,Liquid diet, ...[+2]	Avg patent value: 869,666
39	Kyocera Corp.	Kyoto, Japan	Semiconductor,Electronics,Telecommunications, ...[+2]	Avg patent value: 850,000
40	EA Pharma Co., Ltd.	Tokyo, Japan	Gastrointestinal agent,Ulcerative colitis,Secondary hyperparathyroidism, ...[+2]	Avg patent value: 840,000
41	Kotobuki Pharmaceutical Co. Ltd.	Shizuoka, Japan	Medicine,Health care,Pharmacy and Therapeutics, ...[+2]	Avg patent value: 815,857
42	MC Food Specialties, Inc.	Tokyo, Japan	Food products,Food industry,Food processing, ...[+2]	Avg patent value: 784,800
43	STARTUP Karydo TherapeutiX, Inc.	Tokyo, Japan	Drug	Avg patent value: 550,000
44	Daiichi Sankyo Co., Ltd.	New Jersey, Japan	Clinical trial,Cardiovascular agent,Drug, ...[+2]	Avg patent value: 543,141
45	Kikkoman Corp.	Chiba, Japan	Seasoning,Food industry,Hyaluronic acid, ...[+2]	Avg patent value: 526,200
46	Kao Corp.	Tokyo, Japan	Cosmetics,Health care,Hair conditioner, ...[+2]	Avg patent value: 493,858
47	Fuji Oil Holdings, Inc.	Osaka, Japan	Soy protein,Food processing,Textured vegetable protein, ...[+2]	Avg patent value: 464,545
48	Fuji Oil Co. Ltd. (Osaka)	Osaka, Japan	Agriculture,Fertilizer,Animal fat, ...[+2]	Avg patent value: 464,545
49	Suntory Beverage & Food Ltd.	Tokyo, Japan	Mineral water,Ethanol,Food industry, ...[+2]	Avg patent value: 452,958
50	Sundory Co. Ltd.	Japan		Avg patent value: 452,958
51	Dexerials Corp.	Tokyo, Japan	Electronic component,Polarizer,Electronics, ...[+2]	Avg patent value: 360,000
52	DKK-TOA Corp.	Tokyo, Japan	Sales management,Electronics,Dredging, ...[+2]	Avg patent value: 340,000
53	Asahi Breweries Ltd.	Tokyo, Japan	Microbrewery,Soft drink,Brewing, ...[+2]	Avg patent value: 291,744
54	JNC Corp.	Tokyo, Japan	Electronic component,Petrochemical,Semiconductor, ...[+2]	Avg patent value: 263,000
55	Tsujiko Co., Ltd.	Shiga, Japan	Plant cultivation,Wideband,Semiconductor, ...[+1]	Avg patent value: 260,000
56	Trans Genic Inc.	Fukuoka, Japan	Clinical trial,Diagnostic analysis,Medicine, ...[+2]	Avg patent value: 240,000
57	Toyota Motor Corp.	Aichi, Japan	Sport utility vehicle,Mobile device,Public transport, ...[+2]	Avg patent value: 190,000
58	Toyobo Co., Ltd.	Osaka, Japan	Chemical engineering,Synthetic rubber,Membrane, ...[+2]	Avg patent value: 178,750
59	Senju Pharmaceutical Co., Ltd.	Osaka, Japan	Drug,Glaucoma,Allergy, ...[+2]	Avg patent value: 178,000
60	LOTTE Co., Ltd.	Tokyo, Japan	Ice cream,Chewing gum,Fast foods, ...[+2]	Avg patent value: 170,000
61	Sysmex Corp.	Hokkaido, Japan	Clinical chemistry,Reagent,Medical equipment, ...[+2]	Avg patent value: 130,000
62	API Corp.	Fukuoka, Japan	Medicine,Pharmaceutical formulation,Fine chemical, ...[+1]	Avg patent value: 128,625
63	Sumitomo Pharma Co., Ltd.	Osaka, Japan	Medicine,Health care,Clinical trial, ...[+2]	Avg patent value: 110,000
64	Sumitomo Pharmaceuticals Co., Ltd.	Osaka, Japan	Botanical drug,Herb	Avg patent value: 110,000
65	YAEGAKI Bio-Industry, Inc.	Japan	Natural food,Food industry,Snack foods	Avg patent value: 110,000
66	Takara Shuzo Co., Ltd.	Kyoto, Japan	Seasoning,Ethanol,Food industry, ...[+2]	Avg patent value: 94,000
67	Research Institute of Innovative Technology for the Earth	Kyoto, Japan		Avg patent value: 91,000
68	Oriental Yeast Co., Ltd.	Tokyo, Japan	Yeast,Food industry,Snack foods, ...[+2]	Avg patent value: 77,000
69	Nippon Zeon Co., Ltd.	Tokyo, Japan	Chemical engineering,Solid-state battery,Supercapacitor, ...[+1]	Avg patent value: 77,000
70	Tosoh Corp.	Tokyo, Japan	Petrochemical,Chemical engineering,Immunoprotein, ...[+2]	Avg patent value: 69,500
71	Osaka Gas Co., Ltd.	Osaka, Japan	Natural gas,Activated carbon,Petroleum industry, ...[+2]	Avg patent value: 69,000
72	Ensuiko Sugar Refining Co., Ltd.	Tokyo, Japan	Sugar,Food processing,Sugar refining, ...[+2]	Avg patent value: 63,000
73	Tama Biochemical Co. Ltd.	Japan	Nutraceutical,Medicine,Tocopherol, ...[+2]	Avg patent value: 61,000
74	Miyoshi Kasei, Inc.	Saitama, Japan	Cosmetics,Pigment,Silicon, ...[+2]	Avg patent value: 60,000
75	Nagaoka Perfumery Co., Ltd.	Osaka, Japan	Medical food,Shopping mall,Emulsion	Avg patent value: 60,000
76	Morikawa Kenkodo KK	Japan		Avg patent value: 60,000
77	Saitama Medical University	Japan		Avg patent value: 59,000
78	Mitsui DM Sugar Holdings Co., Ltd.	Tokyo, Japan	Sugar,Refined sugar,Food processing, ...[+2]	Avg patent value: 56,000
79	Toray Fine Chemicals Co., Ltd.	Japan		Avg patent value: 56,000
80	Kakuhiro Co. Ltd.	Japan		Avg patent value: 54,000
81	Mizkan Holdings Co., Ltd.	Aichi, Japan	Seasoning,Food industry,Food products, ...[+2]	Avg patent value: 53,000
82	Tokyo Metropolitan Industrial Technology Research Institute	Tokyo, Japan	Light therapy,Industrial technology,Internet of Things, ...[+2]	Avg patent value: 53,000
83	Mikimoto Pharmaceutical Co. Ltd.	Japan		Avg patent value: 52,000
84	Nissin Foods Holdings Co., Ltd.	Yamanashi, Japan	Food products,Food industry,Pickling, ...[+2]	Avg patent value: 51,500
85	Nissui Pharmaceutical Co., Ltd.	Tokyo, Japan	Medicine,Health care,Diagnostic Reagent, ...[+2]	Avg patent value: 51,000
86	Kyodo Milk Industry Co., Ltd.	Tokyo, Japan	Ice cream,Agriculture	Avg patent value: 51,000
87	Otsuka Pharmaceutical Factory, Inc.	Tokushima, Japan	Parenteral nutrition,Human nutrition,Drug, ...[+2]	Avg patent value: 51,000
88	Shimadzu Corp.	Kyoto, Japan	Molecular diagnostics,Microbiology Test,Cockpit display system, ...[+2]	Avg patent value: 49,000
89	Hayashikane Sangyo Co., Ltd.	Yamaguchi, Japan	Livestock,Food industry,Animal feed, ...[+2]	Avg patent value: 48,000
90	Central Glass Co., Ltd.	Tokyo, Japan	Glazing,Fine chemical,Chemical engineering, ...[+2]	Avg patent value: 45,000
91	TOYO SHINYAKU Co., Ltd.	Saga, Japan	Cosmetics,Food industry,Drug, ...[+1]	Avg patent value: 42,000
92	Sanwa Shurui Co., Ltd.	Oita, Japan	Ethanol,Food industry	Avg patent value: 38,000
93	J-DOLPH Pharmaceutical Co., Ltd.	Osaka, Japan		Avg patent value: 36,000
94	Kirin Holdings Co., Ltd.	Tokyo, Japan	Microbrewery,Seasoning,Soft drink, ...[+2]	Avg patent value: 34,500
95	San-Ei Gen F.F.I., Inc.	Osaka, Japan	Colourant,Food industry,Food material, ...[+2]	Avg patent value: 34,000
96	Nippon Menard Cosmetic Co., Ltd.	Aichi, Japan	Cosmetics	Avg patent value: 31,300
97	Asahi Group Holdings Ltd.	Tokyo, Japan	Soft drink,Food industry,Wellness Programs, ...[+2]	Avg patent value: 21,000
98	Sumitomo Chemical Co., Ltd.	Tokyo, Japan	Petrochemical,Agriculture,Pesticide, ...[+2]	Avg patent value: 20,000
99	Nagase ChemteX Corp.	Osaka, Japan	Functional polymers,Solid-state battery,Epoxy, ...[+2]	Avg patent value: 19,000
100	Jichi Medical University	Japan		Avg patent value: 17,000