Top 100 Key Players companies in Proline by Most Patent Citation in the world in 2019 – Discovery

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The Proline top 100 is Discovery PatSnap’ annual ranking of the top 100 Most Patent Citation Proline Key Players in the world. Discovery has identified the top key players, startups & unicorns, fast-growings, news entrants in 2019, ranking from differnt perspectives, including patent filing intensity, academic research capability, news media heat. The company list is generated from various data types.

Proline (symbol Pro or P) is a proteinogenic amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated NH₂⁺ form under biological conditions), an α-carboxylic acid group (which is in the deprotonated −COO⁻ form under biological conditions), and a side chain pyrrolidine, classifying it as a nonpolar (at physiological pH), aliphatic amino acid. It is non-essential in humans, meaning the body can synthesize it from the non-essential amino acid L-glutamate. It is encoded by all the codons starting CC (CCU, CCC, CCA, and CCG).

1	Novo Nordisk A/S	Hovedstaden, Denmark	Insulin,Health care,Haemophilia, ...[+2]	patent citation: 1,647
2	Monsanto Technology LLC	Missouri, United States		patent citation: 1,353
3	Ajinomoto Co., Inc.	Tokyo, Japan	Seasoning,Amino acid,Food processing, ...[+2]	patent citation: 1,254
4	Mitsubishi Tanabe Pharma Corp.	Osaka, Japan	Medicine,Health care,Toxoid, ...[+2]	patent citation: 1,089
5	Labsystems Oy	Finland	Graphics processing unit,Information technology management,Doppler ultrasound, ...[+2]	patent citation: 1,009
6	Enzon Pharmaceuticals, Inc.	New Jersey, United States	Medicine,Health care,PEGylation, ...[+2]	patent citation: 692
7	Ono Pharmaceutical Co., Ltd.	Osaka, Japan	Diagnostic Reagent,Medicine,Health care, ...[+2]	patent citation: 552
8	Kyowa Hakko Kogyo Co., Ltd.	Tokyo, Japan	Fertilizer,Agrochemical,Raw material, ...[+2]	patent citation: 467
9	The Georgia Tech Research Corp.	United States	Accounting,Association (object-oriented programming),Neurotechnology, ...[+2]	patent citation: 465
10	Merck & Co., Inc.	New Jersey, United States	Health care,Biopharmaceutical,Drug, ...[+2]	patent citation: 403
11	UAB Research Foundation	Alabama, United States	Biotechnology,Agriculture,Fishery, ...[+2]	patent citation: 397
12	Menarini International Operations Luxembourg SA	Luxembourg, Luxembourg	Drug,Medicine	patent citation: 388
13	Pfizer Products, Inc.	Connecticut, United States		patent citation: 381
14	Koninklijke DSM NV	Netherlands	Animal nutrition,Health care,Biology, ...[+2]	patent citation: 365
15	Seikagaku Corp.	Tokyo, Japan	Viscosupplementation,Health care,SURGICAL AIDS, ...[+2]	patent citation: 346
16	Arena Pharmaceuticals, Inc.	California, United States	Health care,Clinical trial,Therapeutic Area, ...[+2]	patent citation: 331
17	Schering Corp.	New Jersey, United States	Hepatitis,Medicine,Allergy	patent citation: 298
18	Pfizer Inc.	New York, United States	Health care,Clinical trial,Drug, ...[+2]	patent citation: 279
19	Sumitomo Pharma Co., Ltd.	Osaka, Japan	Medicine,Health care,Clinical trial, ...[+2]	patent citation: 263
20	Sumitomo Pharmaceuticals Co., Ltd.	Osaka, Japan	Botanical drug,Herb	patent citation: 263
21	Ferring BV	Noord-Holland, Netherlands	Gastroenterology,Viscosupplementation,Infertility, ...[+2]	patent citation: 241
22	Philip Morris GmbH	Germany	Nicotiana tabacum	patent citation: 222
23	Kao Corp.	Tokyo, Japan	Cosmetics,Health care,Hair conditioner, ...[+2]	patent citation: 197
24	F. Hoffmann-La Roche Ltd.	Switzerland	Medicine,Health care,Drug, ...[+2]	patent citation: 197
25	Japan Tobacco, Inc.	Tokyo, Japan	Nicotiana tabacum,Cigarillo,Food sector, ...[+2]	patent citation: 185
26	Novozymes A/S	Hovedstaden, Denmark	Enzyme,Medicine,Industrial enzymes, ...[+2]	patent citation: 178
27	Imperial Chemical Industries Ltd.	United Kingdom	Coating,Industrial engineering,Biocide, ...[+2]	patent citation: 170
28	Triad National Security LLC	Ohio, United States		patent citation: 167
29	Meiji Co., Ltd.	Tokyo, Japan	Food industry,Snack foods,Hard candy, ...[+2]	patent citation: 166
30	Protein Polymer Technologies, Inc.	California, United States	Polymer,Medicine,Biotechnology, ...[+2]	patent citation: 164
31	Suntory Beverage & Food Ltd.	Tokyo, Japan	Mineral water,Ethanol,Food industry, ...[+2]	patent citation: 155
32	Sundory Co. Ltd.	Japan		patent citation: 155
33	The Board of Trustees of The University of Alabama	Alabama, United States	Academic Training,Educational institution,Graduate degree, ...[+2]	patent citation: 144
34	Ciba Specialty Chemicals Holding, Inc.	Basel-Stadt, Switzerland	Chelate agent,Health care,Chemical engineering, ...[+2]	patent citation: 141
35	Smithkline Beckman Corp	Pennsylvania, United States	Biotechnology,Medicine	patent citation: 138
36	XL-protein GmbH	Bayern, Germany	Medicine,Biopharmaceutical,Drug development, ...[+2]	patent citation: 137
37	Astellas Pharma, Inc.	Tokyo, Japan	Health care,Clinical trial,Diabetic complication, ...[+2]	patent citation: 134
38	Kotobuki Pharmaceutical Co. Ltd.	Shizuoka, Japan	Medicine,Health care,Pharmacy and Therapeutics, ...[+2]	patent citation: 134
39	Daiichi Sankyo Co., Ltd.	New Jersey, Japan	Clinical trial,Cardiovascular agent,Drug, ...[+2]	patent citation: 128
40	Hoechst AG	Hessen, Germany	Chemical engineering,Botanical drug,Herb, ...[+2]	patent citation: 125
41	Rhone Poulenc AG Co.	United States		patent citation: 125
42	Professional Dietetics SpA	Italy		patent citation: 124
43	Ciba-Geigy AG	Switzerland	Botanical drug,Herb	patent citation: 123
44	Yamanouchi Pharmaceutical Co., Ltd.	Tokyo, Japan	Drug,Medical equipment,Dental Equipment	patent citation: 121
45	Karolinska Institutet Innovations AB	AB, SE	Incubation	patent citation: 119
46	Riken Corp.	Saitama, Japan	Social network,Tappet,Piston ring, ...[+2]	patent citation: 116
47	CSL Behring GmbH	Hessen, Germany	Medicine	patent citation: 116
48	Merck Sharp & Dohme Corp.	New Jersey, United States	Prescription drug,Medicine,Stroke, ...[+2]	patent citation: 115
49	BP Nutrition	GB	Nutrition,Food industry	patent citation: 115
50	Agricultural Genetics Co. Ltd.	United Kingdom	Agricultural biotechnology,Plant breeding	patent citation: 115
51	Lallemand Animal Nutrition UK Ltd.	Worcestershire, United Kingdom	Animal nutrition,Silage,Agriculture, ...[+2]	patent citation: 115
52	Unilever U.K. Central Resources Ltd.	GL, GB		patent citation: 115
53	Twyford Seeds Ltd.	HD, GB		patent citation: 115
54	Guilford Pharmaceuticals, Inc.	United States	Drug,Botanical drug,Herb, ...[+2]	patent citation: 111
55	Degussa AG	Hessen, Germany	Precious metal,Chemical engineering,Nutrition, ...[+2]	patent citation: 106
56	Beech Mountain Resort, Inc.	North Carolina, United States	Leisure satisfaction,Laundry	patent citation: 104
57	Celgene Corp.	New Jersey, United States	Health care,Cytogenetic Abnormality,Medicine, ...[+2]	patent citation: 103
58	NIPPON STEEL Stainless Steel Corp.	Tokyo, Japan	Mill,Metal,Mining engineering, ...[+1]	patent citation: 100
59	Thar Pharmaceuticals, Inc.	Pennsylvania, United States	Prescription drug,Medical equipment,Medicine, ...[+2]	patent citation: 100
60	Riboxx GmbH	Sachsen, Germany	RNA interference,RNA,In vitro, ...[+2]	patent citation: 97
61	Yeda Research & Development Co. Ltd.	HaMerkaz, Israel	Association (object-oriented programming),Intellectual property,Biotechnology, ...[+2]	patent citation: 96
62	Errekappa Euroterapici SpA	Lombardia, Italy	Heart failure,Health care,Medicine, ...[+1]	patent citation: 95
63	Pentraxin Therapeutics Ltd.	United Kingdom	Drug discovery,Health care,Pharmacy and Therapeutics, ...[+1]	patent citation: 93
64	LIFETECH Co., Ltd.	Saitama, Japan	Automation,Computer hardware,Electronics	patent citation: 93
65	B·R·A·H·M·S GmbH	Brandenburg, Germany	Molecular diagnostics,Diagnostic test,Medicine, ...[+2]	patent citation: 92
66	Bracco Imaging SpA	Italy	Magnetic resonance imaging,X-ray,Medicine, ...[+2]	patent citation: 91
67	Miles, Inc.	Kansas, United States	Mobile app,Chemical engineering	patent citation: 91
68	Zeneca, Inc.	DE, US		patent citation: 89
69	Neurochem (International) Ltd.	Vaud, Switzerland	Supply chain management	patent citation: 88
70	Abbott Laboratories Ltd.	United Kingdom	Medicine,Photomedicine,Drug carrier, ...[+2]	patent citation: 87
71	Enanta Pharmaceuticals, Inc.	Massachusetts, United States	Medicine,Health care,Protease, ...[+2]	patent citation: 86
72	Eisai Co., Ltd.	Tokyo, Japan	Health care,Over-the-counter,Clinical trial, ...[+2]	patent citation: 85
73	Nippon Paper Industries Co., Ltd.	Tokyo, Japan	Paperboard,Forestry,Paper mill, ...[+2]	patent citation: 85
74	STARTUP SyntheX, Inc.	California, United States	Biology,Medicine,Pharmacy and Therapeutics, ...[+2]	patent citation: 84
75	L'Oréal SA	Île-de-France, France	Cosmetics,Urban decay,Hair conditioner, ...[+2]	patent citation: 83
76	Lion Corp.	Tokyo, Japan	Toothpaste,Fast-moving consumer goods,Laundry, ...[+2]	patent citation: 83
77	Omnichem Co., Ltd.	DE, KR	Coating,Pharmaceutical manufacturing,Industrial engineering, ...[+2]	patent citation: 82
78	American Home Products LLC	California, United States	Forestry	patent citation: 80
79	The Louver Shop	United States	Window shutter,Louver,Interior design	patent citation: 80
80	Glaxo Group Ltd.	Hounslow, United Kingdom	Food products,Medicine,Health care	patent citation: 79
81	Bayer AG	Nordrhein-Westfalen, Germany	Health care,Biology,Chemical engineering, ...[+2]	patent citation: 78
82	Bayer Oy	Finland		patent citation: 78
83	Siemens Healthcare Diagnostics Products GmbH	Hessen, Germany	Medicine	patent citation: 77
84	Sankyo Co., Ltd.	Tokyo, Japan	Ball bearing,Manufacturing engineering,Glatiramer acetate, ...[+2]	patent citation: 75
85	Eolas Therapeutics, Inc.	California, United States	Addiction,Pharmacy and Therapeutics,Nicotine, ...[+2]	patent citation: 75
86	Kaneka Corp.	Tokyo, Japan	Synthetic rubber,Chemical engineering,Polyvinyl chloride, ...[+2]	patent citation: 74
87	Boehringer Ingelheim KG	Germany	Medicine	patent citation: 73
88	Akzo Nobel NV	Noord-Holland, Netherlands	Coating,Powder coating,Chemical engineering, ...[+2]	patent citation: 72
89	Bayer HealthCare Pharmaceuticals, Inc.	New Jersey, United States	Medicine,Cardiovascular agent,Clinical trial, ...[+2]	patent citation: 72
90	American Can Co.	United States	Tin can,Packaging engineering,Microservices, ...[+1]	patent citation: 72
91	Mycogen LLC	Indiana, United States	Biotechnology,Medicine,Fertilizer, ...[+2]	patent citation: 71
92	Massachusetts General Hospital	Massachusetts, United States	Substance abuse,Hospitality industry,Health care, ...[+2]	patent citation: 71
93	The General Hospital Corp.	Massachusetts, United States	Health care,Hospitality industry,Vascular Medicine, ...[+2]	patent citation: 71
94	Genentech, Inc.	California, United States	Biotechnology,Biology,Medicine, ...[+2]	patent citation: 70
95	Spine Wave, Inc.	Connecticut, United States	Medical equipment,Spinal fusion,mHealth, ...[+2]	patent citation: 69
96	Hisamitsu Pharmaceutical Co., Inc.	Saga, Japan	Salonpas,Medicine,Health care, ...[+2]	patent citation: 68
97	TheraCarb, Inc.	AB, CA	Biotechnology	patent citation: 68
98	Fuso Pharmaceutical Industries Ltd.	Osaka, Japan	Medical equipment,Health care,Malic acid, ...[+2]	patent citation: 67
99	Uponor Innovation AB	Sweden		patent citation: 67
100	AbbVie, Inc.	Illinois, United States	Health care,Medicine,Biopharmaceutical, ...[+2]	patent citation: 65