Top 100 Key Players companies in Proline by Most Patent Citation in the Japan in 2018 – Discovery

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The Proline top 100 is Discovery PatSnap’ annual ranking of the top 100 Most Patent Citation Proline Key Players in the Japan. Discovery has identified the top key players, startups & unicorns, fast-growings, news entrants in 2018, ranking from differnt perspectives, including patent filing intensity, academic research capability, news media heat. The company list is generated from various data types.

Proline (symbol Pro or P) is a proteinogenic amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated NH₂⁺ form under biological conditions), an α-carboxylic acid group (which is in the deprotonated −COO⁻ form under biological conditions), and a side chain pyrrolidine, classifying it as a nonpolar (at physiological pH), aliphatic amino acid. It is non-essential in humans, meaning the body can synthesize it from the non-essential amino acid L-glutamate. It is encoded by all the codons starting CC (CCU, CCC, CCA, and CCG).

1	Ajinomoto Co., Inc.	Tokyo, Japan	Seasoning,Amino acid,Food processing, ...[+2]	patent citation: 1,254
2	Mitsubishi Tanabe Pharma Corp.	Osaka, Japan	Medicine,Health care,Toxoid, ...[+2]	patent citation: 1,089
3	Ono Pharmaceutical Co., Ltd.	Osaka, Japan	Diagnostic Reagent,Medicine,Health care, ...[+2]	patent citation: 552
4	Kyowa Hakko Kogyo Co., Ltd.	Tokyo, Japan	Fertilizer,Agrochemical,Raw material, ...[+2]	patent citation: 467
5	Seikagaku Corp.	Tokyo, Japan	Viscosupplementation,Health care,SURGICAL AIDS, ...[+2]	patent citation: 346
6	Sumitomo Pharma Co., Ltd.	Osaka, Japan	Medicine,Health care,Clinical trial, ...[+2]	patent citation: 263
7	Sumitomo Pharmaceuticals Co., Ltd.	Osaka, Japan	Botanical drug,Herb	patent citation: 263
8	Kao Corp.	Tokyo, Japan	Cosmetics,Health care,Hair conditioner, ...[+2]	patent citation: 197
9	Japan Tobacco, Inc.	Tokyo, Japan	Nicotiana tabacum,Cigarillo,Food sector, ...[+2]	patent citation: 185
10	Meiji Co., Ltd.	Tokyo, Japan	Food industry,Snack foods,Hard candy, ...[+2]	patent citation: 166
11	Suntory Beverage & Food Ltd.	Tokyo, Japan	Mineral water,Ethanol,Food industry, ...[+2]	patent citation: 155
12	Sundory Co. Ltd.	Japan		patent citation: 155
13	Astellas Pharma, Inc.	Tokyo, Japan	Health care,Clinical trial,Diabetic complication, ...[+2]	patent citation: 134
14	Kotobuki Pharmaceutical Co. Ltd.	Shizuoka, Japan	Medicine,Health care,Pharmacy and Therapeutics, ...[+2]	patent citation: 134
15	Daiichi Sankyo Co., Ltd.	New Jersey, Japan	Clinical trial,Cardiovascular agent,Drug, ...[+2]	patent citation: 128
16	Yamanouchi Pharmaceutical Co., Ltd.	Tokyo, Japan	Drug,Medical equipment,Dental Equipment	patent citation: 121
17	Riken Corp.	Saitama, Japan	Social network,Tappet,Piston ring, ...[+2]	patent citation: 116
18	NIPPON STEEL Stainless Steel Corp.	Tokyo, Japan	Mill,Metal,Mining engineering, ...[+1]	patent citation: 100
19	LIFETECH Co., Ltd.	Saitama, Japan	Automation,Computer hardware,Electronics	patent citation: 93
20	Eisai Co., Ltd.	Tokyo, Japan	Health care,Over-the-counter,Clinical trial, ...[+2]	patent citation: 85
21	Nippon Paper Industries Co., Ltd.	Tokyo, Japan	Paperboard,Forestry,Paper mill, ...[+2]	patent citation: 85
22	Lion Corp.	Tokyo, Japan	Toothpaste,Fast-moving consumer goods,Laundry, ...[+2]	patent citation: 83
23	Sankyo Co., Ltd.	Tokyo, Japan	Ball bearing,Manufacturing engineering,Glatiramer acetate, ...[+2]	patent citation: 75
24	Kaneka Corp.	Tokyo, Japan	Synthetic rubber,Chemical engineering,Polyvinyl chloride, ...[+2]	patent citation: 74
25	Hisamitsu Pharmaceutical Co., Inc.	Saga, Japan	Salonpas,Medicine,Health care, ...[+2]	patent citation: 68
26	Fuso Pharmaceutical Industries Ltd.	Osaka, Japan	Medical equipment,Health care,Malic acid, ...[+2]	patent citation: 67
27	Sumitomo Chemical Co., Ltd.	Tokyo, Japan	Petrochemical,Agriculture,Pesticide, ...[+2]	patent citation: 58
28	Otsuka Pharmaceutical Co., Ltd.	Tokyo, Japan	Nutraceutical,Health care,Cosmetics, ...[+2]	patent citation: 58
29	Central Glass Co., Ltd.	Tokyo, Japan	Glazing,Fine chemical,Chemical engineering, ...[+2]	patent citation: 57
30	Tonen General Sekiyu KK	Chiba, Japan	Petroleum product,Petrochemical,Liquefied natural gas, ...[+2]	patent citation: 57
31	Teika Pharmaceutical Co., Ltd.	Okinawa, Japan	Medicine,Quality control,Hygiene, ...[+2]	patent citation: 54
32	Shiseido Co., Ltd.	Tokyo, Japan	Cosmetics,Elixir,Personal Care Product, ...[+2]	patent citation: 50
33	KOSÉ Corp.	Tokyo, Japan	Cosmetics,Fast-moving consumer goods,Added value, ...[+2]	patent citation: 50
34	Otsuka Pharmaceutical Factory, Inc.	Tokushima, Japan	Parenteral nutrition,Human nutrition,Drug, ...[+2]	patent citation: 49
35	ADVANCE Co., Ltd.	Tokyo, Japan	Medicine,Flora,Blood flow, ...[+2]	patent citation: 47
36	Sanyo Trading Co., Ltd.	Tokyo, Japan	Synthetic rubber,Dispersant,Scientific instrument, ...[+2]	patent citation: 45
37	Hoyu Co., Ltd.	Aichi, Japan	Cosmetics,Hair conditioner,Colourant, ...[+1]	patent citation: 42
38	Kyowa Kirin Co., Ltd.	Tokyo, Japan	Health care,Drug,Medicine, ...[+2]	patent citation: 38
39	Tama Biochemical Co. Ltd.	Japan	Nutraceutical,Medicine,Tocopherol, ...[+2]	patent citation: 38
40	Hayashikane Sangyo Co., Ltd.	Yamaguchi, Japan	Livestock,Food industry,Animal feed, ...[+2]	patent citation: 37
41	Ichimaru Pharcos Co. Ltd.	Japan	Raw material,Cosmetics	patent citation: 37
42	Myojo Foods Co., Ltd.	Tokyo, Japan	Food industry,Snack foods	patent citation: 36
43	Taisho Pharmaceutical Co., Ltd.	Tokyo, Japan	Medicine,Self-medication,Drug, ...[+2]	patent citation: 34
44	Tsumura & Co.	Tokyo, Japan	Raw material,Pharmacy,Clinical trial, ...[+2]	patent citation: 32
45	Asahi Breweries Ltd.	Tokyo, Japan	Microbrewery,Soft drink,Brewing, ...[+2]	patent citation: 32
46	Amano Enzyme, Inc.	Nagano, Japan	Enzyme,Drug,Chemical engineering, ...[+2]	patent citation: 31
47	Takeda Pharmaceutical Co., Ltd.	Osaka, Japan	Medicine,Health care,Clinical trial, ...[+2]	patent citation: 30
48	Fuji Oil Holdings, Inc.	Osaka, Japan	Soy protein,Food processing,Textured vegetable protein, ...[+2]	patent citation: 30
49	Miyoshi Kasei, Inc.	Saitama, Japan	Cosmetics,Pigment,Silicon, ...[+2]	patent citation: 30
50	Takeda Chemical Industries Ltd.	Japan	Pharmaceutical drug,Botanical drug,Herb	patent citation: 30
51	Fuji Oil Co. Ltd. (Osaka)	Osaka, Japan	Agriculture,Fertilizer,Animal fat, ...[+2]	patent citation: 30
52	Evonik Degussa Japan Co., Ltd.	Tokyo, Japan		patent citation: 30
53	Teijin Ltd.	Tokyo, Japan	Synthetic rubber,Chemical engineering,Polycarbonate, ...[+2]	patent citation: 27
54	Shimizu Pharmaceutical Co., Ltd.	Shizuoka, Japan	Medical equipment,Medicine	patent citation: 27
55	Eisai R&D Management Co., Ltd.	Tokyo, Japan	Biotechnology,Agriculture,Fishery, ...[+2]	patent citation: 26
56	Kikkoman Corp.	Chiba, Japan	Seasoning,Food industry,Hyaluronic acid, ...[+2]	patent citation: 23
57	Nippon Kayaku Co., Ltd.	Tokyo, Japan	Biosimilar,Chemical engineering,Industrial engineering, ...[+2]	patent citation: 23
58	Kaken Pharmaceutical Co., Ltd.	Tokyo, Japan	Agrochemical,Medicine,Medical equipment, ...[+2]	patent citation: 21
59	Toyobo Co., Ltd.	Osaka, Japan	Chemical engineering,Synthetic rubber,Membrane, ...[+2]	patent citation: 20
60	Chugai Pharmaceutical Co., Ltd.	Tokyo, Japan	Drug,Clinical trial,Health care, ...[+2]	patent citation: 20
61	Yakult Honsha Co., Ltd.	Tokyo, Japan	Probiotic,Food industry,Health care, ...[+2]	patent citation: 19
62	Shimadzu Corp.	Kyoto, Japan	Molecular diagnostics,Microbiology Test,Cockpit display system, ...[+2]	patent citation: 19
63	Fuji Shoji Co., Ltd.	Tokyo, Japan	Food additive,Chemical engineering	patent citation: 19
64	Multi & Relational System Co., Ltd.	Niigata, Japan	Web development	patent citation: 19
65	Sasaki Chemical Industry Co. Ltd.	Japan		patent citation: 19
66	Shionogi & Co., Ltd.	Osaka, Japan	Health care,Antihypercholesterolemic agent,Drug, ...[+2]	patent citation: 17
67	Sagami Chemical Research Center	Kanagawa, Japan		patent citation: 17
68	Sumitomo Electric Industries Ltd.	Osaka, Japan	Electronics,Optical fiber,Optical fiber cable, ...[+2]	patent citation: 16
69	Toray Industries, Inc.	Tokyo, Japan	Fiber,Textile,Textile (markup language), ...[+2]	patent citation: 16
70	Showa Denko K.K.	Chiba, Japan	Graphite,Materials science,Nanomaterials, ...[+2]	patent citation: 16
71	Sumitomo Electric	Osaka, Japan	Optical fiber,Electronics,Optical fiber cable	patent citation: 16
72	Tsujiko Co., Ltd.	Shiga, Japan	Plant cultivation,Wideband,Semiconductor, ...[+1]	patent citation: 16
73	Japan Atomic Energy Research Institute	Japan	Basic law	patent citation: 16
74	Daicel Corp.	Chiba, Japan	Airbag,Chemical engineering,Cellulose acetate, ...[+2]	patent citation: 15
75	Nissan Chemical Corp.	Tokyo, Japan	Pesticide,Meiji period,Fertilizer, ...[+2]	patent citation: 15
76	Nippon Soda Co., Ltd.	Tokyo, Japan	Pesticide,Fungicide,Chemical engineering, ...[+2]	patent citation: 15
77	Hodogaya Chemical Co., Ltd.	Tokyo, Japan	Pigment,Chemical engineering,Functional polymers, ...[+2]	patent citation: 15
78	Hokuren Federation of Agricultural Cooperatives	Hokkaido, Japan	Horticulture,Farming industry,Agriculture	patent citation: 15
79	Itochu Feed Mills Co., Ltd.	Tokyo, Japan	Agriculture	patent citation: 15
80	Daiwa Pharmaceutical Co., Ltd.	Toyama, Japan		patent citation: 15
81	Hitachi Ltd.	Tokyo, Japan	Elevator,Electrical equipment,Electric motor, ...[+2]	patent citation: 14
82	Koken Ltd.	Kanagawa, Japan	Gas mask,Medical equipment,Sanitation, ...[+2]	patent citation: 14
83	API Corp.	Fukuoka, Japan	Medicine,Pharmaceutical formulation,Fine chemical, ...[+1]	patent citation: 14
84	Nippon Zeon Co., Ltd.	Tokyo, Japan	Chemical engineering,Solid-state battery,Supercapacitor, ...[+1]	patent citation: 14
85	Tosoh Corp.	Tokyo, Japan	Petrochemical,Chemical engineering,Immunoprotein, ...[+2]	patent citation: 13
86	Zeria Pharmaceutical Co., Ltd.	Tokyo, Japan	Drug,Gastrointestinal agent,Self-medication, ...[+2]	patent citation: 13
87	Mercian Corp.	Tokyo, Japan	Wine,Food industry,Fortified wine, ...[+2]	patent citation: 13
88	Roussel Morishita Co., Ltd.	Akita, Japan		patent citation: 13
89	Mitsui Chemicals, Inc.	Tokyo, Japan	Petrochemical,Chemical engineering,Polypropylene, ...[+2]	patent citation: 12
90	Mizkan Co., Ltd.	Aichi, Japan	Seasoning,Food industry,Snack foods	patent citation: 12
91	Air Water, Inc.	Osaka, Japan	Industrial gas,Enterprise software,Nitrogen, ...[+2]	patent citation: 11
92	Tokuyama Corp.	Tokyo, Japan	Cement,Chemical engineering,Fumed silica, ...[+2]	patent citation: 11
93	Banyu Pharmaceutical Co. Ltd.	Tokyo, Japan	Drug,Health care,Medicine	patent citation: 11
94	Teijin Pharma Ltd.	Tokyo, Japan	Medical equipment,Respiratory disease,Oxygen concentrator, ...[+2]	patent citation: 11
95	The Chemo-Sero-Therapeutic Research Institute	Kumamoto, Japan	Blood plasma,Medicine,Suture (anatomy), ...[+2]	patent citation: 11
96	Idemitsu Kosan Co., Ltd.	Tokyo, Japan	Petrochemical,Lubricant,Petroleum, ...[+2]	patent citation: 10
97	Pola Chemical Industries, Inc.	Kanagawa, Japan	Chemical industry,Shopping mall,Cosmetics	patent citation: 10
98	DNAVEC Research, Inc.	Ibaraki, Japan		patent citation: 10
99	Senju Pharmaceutical Co., Ltd.	Osaka, Japan	Drug,Glaucoma,Allergy, ...[+2]	patent citation: 9
100	Takara Shuzo Co., Ltd.	Kyoto, Japan	Seasoning,Ethanol,Food industry, ...[+2]	patent citation: 9