Top 20 Key Players companies in Calprotectin by Highest Patent Value in the world in 2018 – Discovery

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The Calprotectin top 20 is Discovery PatSnap’ annual ranking of the top 20 Highest Patent Value Calprotectin Key Players in the world. Discovery has identified the top key players, startups & unicorns, fast-growings, news entrants in 2018, ranking from differnt perspectives, including patent filing intensity, academic research capability, news media heat. The company list is generated from various data types.

Calprotectin is a complex of the mammalian proteins S100A8 and S100A9. In the presence of calcium, calprotectin is capable of sequestering the transition metals iron, manganese and zinc via chelation. This metal sequestration affords the complex antimicrobial properties. Calprotectin is the only known antimicrobial manganese sequestration protein complex. Calprotectin comprises as much as 60% of the soluble protein content of the cytosol of a neutrophil, and it is secreted by an unknown mechanism during inflammation. Faecal calprotectin has been used to detect intestinal inflammation (colitis or enteritis) and can serve as a biomarker for inflammatory bowel diseases and Rheumatoid Arthritis. Other names for calprotectin include MRP8-MRP14, calgranulin A and B, cystic fibrosis antigen, L1, 60BB antigen, and 27E10 antigen.

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Ranking:

1	Axis-Shield AS	Norway		Avg patent value: 2.58 M
2	Academisch Ziekenhuis Maastricht	Netherlands	Medical research,Health care,Hospitality industry	Avg patent value: 1.25 M
3	Bühlmann Laboratories AG	Basel-Stadt, Switzerland	Drug discovery,Pharmacology	Avg patent value: 775,550
4	Shanghai Gebaide Biotechnology Co., Ltd.	China		Avg patent value: 100,000
5	S.L.A. Pharma AG	Basel-Landschaft, Switzerland	Familial adenomatous polyposis,Health care,Gastrointestinal agent, ...[+1]	Avg patent value: 66,000
6	Mologic Ltd.	Northamptonshire, United Kingdom	Medical equipment,Health care,Clinical trial, ...[+2]	Avg patent value: 63,000
7	Shiseido Co., Ltd.	Tokyo, Japan	Cosmetics,Elixir,Personal Care Product, ...[+2]	Avg patent value: 57,000
8	Certest Biotec SL	Spain	Biotechnology,Helicobacter,In vitro, ...[+2]	Avg patent value: 43,000
9	DiaSys Diagnostic Systems GmbH	Rheinland-Pfalz, Germany	Medicine,Photometer,Point-of-care testing, ...[+2]	Avg patent value: 36,000
10	Immundiagnostik AG	Hessen, Germany	Health care,Scientific organization,Business relations, ...[+2]	Avg patent value: 32,500
11	Nature's Sunshine Products, Inc.	Utah, United States	Vitamin,Medical equipment,Herb, ...[+2]	Avg patent value: 19,000
12	ProciseDx LLC	California, United States	Retail clinic,Software,Enterprise software, ...[+2]	Avg patent value: 14,000
13	Zhuhai Encode Medical Engineering Co., Ltd.	Guangdong Sheng, China	Medical laboratory,Health care	Avg patent value: 3,700
14	Lion Corp.	Tokyo, Japan	Toothpaste,Fast-moving consumer goods,Laundry, ...[+2]	Avg patent value: 3,600
15	Zhuhai Keyu Biological Engineering Co., Ltd.	China		Avg patent value: 3,500
16	Eli Lilly & Co.	Indiana, United States	Medicine,Health care,Humalog Mix, ...[+2]	Avg patent value: 0
17	Shofu, Inc.	Kyoto, Japan	Medical equipment,Cosmetics,Macropinocytic cup, ...[+2]	Avg patent value: 0
18	Probi AB	Sweden	Probiotic,Functional food,Food industry, ...[+2]	Avg patent value: 0
19	F. Hoffmann-La Roche Ltd.	Switzerland	Medicine,Health care,Drug, ...[+2]	Avg patent value: 0
20	Roche Diagnostics Corp.	Indiana, United States	Medicine,Urinalysis,Immunoassay, ...[+2]	Avg patent value: 0