Top 20 Key Players companies in Dicer by Most Literature Citation in the United States in 2018 – Discovery

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The Dicer top 20 is Discovery PatSnap’ annual ranking of the top 20 Most Literature Citation Dicer Key Players in the United States. Discovery has identified the top key players, startups & unicorns, fast-growings, news entrants in 2018, ranking from differnt perspectives, including patent filing intensity, academic research capability, news media heat. The company list is generated from various data types.

Dicer, also known as endoribonuclease Dicer or helicase with RNase motif, is an enzyme that in humans is encoded by the DICER1 gene. Being part of the RNase III family, Dicer cleaves double-stranded RNA (dsRNA) and pre-microRNA (pre-miRNA) into short single-stranded RNA fragments called small interfering RNA and microRNA, respectively. These fragments are approximately 20-25 base pairs long with a two-base overhang on the 5' ends. Dicer facilitates the activation of the RNA-induced silencing complex (RISC), which is essential for RNA interference. RISC has a catalytic component Argonaute, which is an endonuclease capable of degrading messenger RNA (mRNA).

1	Howard Hughes Medical Institute	United States	Science education,Medical equipment,Health care, ...[+2]	Literature citation: 4,413
2	Amgen, Inc.	California, United States	Health care,Biopharmaceutical,TUMOR NECROSIS FACTOR BLOCKER, ...[+2]	Literature citation: 2,359
3	Beth Israel Deaconess Medical Center, Inc.	Massachusetts, United States	Medical school,Clinical research,Health care, ...[+2]	Literature citation: 1,482
4	The Brigham & Women's Hospital, Inc.	Massachusetts, United States	Health care,Mitral valve surgery,Health equity, ...[+2]	Literature citation: 913
5	Gordon and Betty Moore Foundation	California, United States	Conservation,Social network,Environmental consulting, ...[+1]	Literature citation: 564
6	Merck & Co., Inc.	New Jersey, United States	Health care,Biopharmaceutical,Drug, ...[+2]	Literature citation: 512
7	Eli Lilly & Co.	Indiana, United States	Medicine,Health care,Humalog Mix, ...[+2]	Literature citation: 495
8	The Boston Biomedical Research Institute	Massachusetts, United States	Health care,Cellular communication,Heart disease	Literature citation: 372
9	Pharmacy Advantage	Michigan, United States	Health care,Specialty pharmacy,Pharmacy, ...[+2]	Literature citation: 304
10	Henry Ford Hospital	MI, US	Group practices,Health care,Hospitality industry	Literature citation: 198
11	Memorial Hospital & Health System	Indiana, United States	Health care,Hospitality industry,Childbirth, ...[+2]	Literature citation: 190
12	Science Applications International Corp.	Virginia, United States	Systems design,Software,Systems engineering, ...[+2]	Literature citation: 155
13	Boyce Thompson Institute for Plant Research, Inc.	New York, United States	Plant pathology,Chemical biology,Molecular biology	Literature citation: 125
14	Integrated DNA Technologies, Inc.	Iowa, United States	DNA,Medicine,Health care, ...[+2]	Literature citation: 119
15	Van Andel Institute	Michigan, United States	Germline,Xenotransplantation,Cytogenetics, ...[+2]	Literature citation: 117
16	The Broad Institute, Inc.	Massachusetts, United States	Clinical trial,Biology,Genomics, ...[+2]	Literature citation: 103
17	The National Research Council	District of Columbia, United States	Public opinion,Health care,Chemistry, ...[+2]	Literature citation: 55
18	Cleveland Clinic Lerner Research Institute	Ohio, United States	Genomic medicine,Molecular medicine,Molecular genetics, ...[+2]	Literature citation: 50
19	Dow AgroSciences LLC	Indiana, United States	Pesticide,Agriculture,SmartStax, ...[+2]	Literature citation: 35
20	The Ohio State University Wexner Medical Center	Ohio, United States	Health care,Microbiome,Medicine, ...[+2]	Literature citation: 35