Top 50 Key Players companies in Calprotectin by Most Literature Citation in the world in 2018 – Discovery

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The Calprotectin top 50 is Discovery PatSnap’ annual ranking of the top 50 Most Literature Citation Calprotectin Key Players in the world. Discovery has identified the top key players, startups & unicorns, fast-growings, news entrants in 2018, ranking from differnt perspectives, including patent filing intensity, academic research capability, news media heat. The company list is generated from various data types.

Calprotectin is a complex of the mammalian proteins S100A8 and S100A9. In the presence of calcium, calprotectin is capable of sequestering the transition metals iron, manganese and zinc via chelation. This metal sequestration affords the complex antimicrobial properties. Calprotectin is the only known antimicrobial manganese sequestration protein complex. Calprotectin comprises as much as 60% of the soluble protein content of the cytosol of a neutrophil, and it is secreted by an unknown mechanism during inflammation. Faecal calprotectin has been used to detect intestinal inflammation (colitis or enteritis) and can serve as a biomarker for inflammatory bowel diseases and Rheumatoid Arthritis. Other names for calprotectin include MRP8-MRP14, calgranulin A and B, cystic fibrosis antigen, L1, 60BB antigen, and 27E10 antigen.

1	Helsinki University Central Hospital	Finland	Medicine,Internal medicine,Surgery, ...[+2]	Literature citation: 1,261
2	Max Planck Gesellschaft zur Förderung der Wissenschaften eV	Bayern, Germany	Basic research,Publishing,Market research, ...[+2]	Literature citation: 1,215
3	Oslo universitetssykehus HF	Oslo, Norway	Medical research,Health care,Oncology, ...[+2]	Literature citation: 770
4	German Cancer Research Center	Baden-Württemberg, Germany	Cancer research,Biology,Cancer, ...[+2]	Literature citation: 580
5	Robarts Research Institute	Ontario, Canada	Medical research,Cancer	Literature citation: 369
6	Ghent University Hospital	Belgium	Flemish,Hospitality industry,Health care, ...[+2]	Literature citation: 321
7	Analytica AB	Sweden	Nondestructive testing,Analytical Testing,Biological Testing	Literature citation: 314
8	Nycomed BV	NL	Tralokinumab,Revefenacin,Asthma, ...[+2]	Literature citation: 311
9	Sheba Medical Center	Tel Aviv, Israel	Health care,Intubation,Tracheal tube, ...[+2]	Literature citation: 303
10	Helse Bergen HF Haukeland Universitetssjukehus	Hordaland, Norway	Regional hospital,Oncology,Breast cancer, ...[+2]	Literature citation: 265
11	Universitätsspital Basel	Switzerland	Health care,Cell therapy,Monoclonal antibody, ...[+2]	Literature citation: 263
12	Istituto Superiore di Sanità	Lazio, Italy	Association (object-oriented programming),Working group,Public institution, ...[+1]	Literature citation: 251
13	Glasgow Royal Infirmary		City centre	Literature citation: 207
14	London Research Institute	United Kingdom	Cancer research	Literature citation: 203
15	Bristol Myers Squibb Co.	New York, United States	Medicine,Health care,Oncology drugs, ...[+2]	Literature citation: 195
16	Sykehuset Innlandet HF	Hedmark, Norway	Mental health,Drug	Literature citation: 165
17	Instituto De SAlud Carlos Iii De Madrid	Spain	Cancer immunotherapy,Immunotherapy,Monoclonal antibody, ...[+2]	Literature citation: 165
18	Family Research Institute Inc	United States	Homosexuality,Empirical research,Social policy, ...[+2]	Literature citation: 165
19	Stavanger University Hospital	Rogaland, Norway	Drug,Clinical research	Literature citation: 155
20	BBVA USA	Alabama, United States		Literature citation: 154
21	Cliniques Universitaires Saint-Luc	Vlaams-Brabant, Belgium	Health care,Hospitality industry	Literature citation: 148
22	AstraZeneca Plc	Cambridgeshire, United Kingdom	Medicine,Health care,Side effect, ...[+2]	Literature citation: 145
23	Ninewells Hospital	United Kingdom	Psychosurgery,Medical genetics,Laparoscopic surgery, ...[+2]	Literature citation: 140
24	Rambam Health Care Campus	Israel	Health care,Hospitality industry,Peacekeeping, ...[+2]	Literature citation: 127
25	Novartis AG	Basel-Stadt, Switzerland	Dosage form,Health care,Medicine, ...[+2]	Literature citation: 102
26	Research Triangle Foundation	North Carolina, United States	Science park	Literature citation: 98
27	Fenway Community Health Center, Inc.	Massachusetts, United States	Transgender,Community health center	Literature citation: 98
28	Shiga University of Medical Science	Shiga, Japan	Medical science	Literature citation: 86
29	Odense University Hospital	Denmark	Hospital unit	Literature citation: 77
30	Nestlé SA	Vaud, Switzerland	Ice cream,Nutrition,Cosmetics, ...[+2]	Literature citation: 75
31	Exponent, Inc.	California, United States	Expert witness,Legal proceeding,Manufacturing process, ...[+2]	Literature citation: 75
32	Leids Universitair Medisch Centrum	Zuid-Holland, Netherlands	Medical research,Hospitality industry,Health care, ...[+2]	Literature citation: 74
33	VUmc	Noord-Holland, Netherlands	Enterprise mobility management,Health care	Literature citation: 73
34	Turku University Hospital	Finland	Health care,Hospitality industry	Literature citation: 67
35	Teknologian Tutkimuskeskus VTT Oy	Southern Finland, Finland	Telecommunications,Applied research,Solar cell, ...[+2]	Literature citation: 66
36	Umeå University	Vasterbottens Lan, Sweden	Microbiome,Biopharmaceutical	Literature citation: 62
37	St James's University Hospital	West Yorkshire, United Kingdom	Medicine,Surgery,Internal medicine, ...[+2]	Literature citation: 57
38	Medisch Spectrum Twente	Overijssel, Netherlands	Health care,Hospitality industry	Literature citation: 54
39	Radboud University Medical Center	Gelderland, Netherlands	Bioinformatics,Molecular diagnostics,Immunotherapy, ...[+2]	Literature citation: 48
40	Advanced Industrial Science & Technology	Tokyo, Japan	Graphene,Association (object-oriented programming)	Literature citation: 47
41	Sahlgrenska Universitetssjukhuset	Västra Götaland, Sweden	Health care,Hospitality industry,Patiromer, ...[+2]	Literature citation: 45
42	Janssen Pharmaceutica NV	Antwerpen, Belgium	Product design,Neuroscience,Health care, ...[+2]	Literature citation: 40
43	Hitachi Ltd.	Tokyo, Japan	Elevator,Electrical equipment,Electric motor, ...[+2]	Literature citation: 38
44	Århus Universitetshospital	Denmark	Medical treatment,Hospitality industry,Health care, ...[+2]	Literature citation: 36
45	Memorial Hospital & Health System	Indiana, United States	Health care,Hospitality industry,Childbirth, ...[+2]	Literature citation: 35
46	Hospital Universitario La Paz	Madrid, Spain	Cardiovascular agent	Literature citation: 34
47	MRC Laboratory of Molecular Biology	Cambridgeshire, United Kingdom	Molecular biology,Macromolecule,Monoclonal antibody, ...[+1]	Literature citation: 33
48	The Intelligence and National Security Alliance (INSA)	Virginia, United States	National security	Literature citation: 33
49	The Brigham & Women's Hospital, Inc.	Massachusetts, United States	Health care,Mitral valve surgery,Health equity, ...[+2]	Literature citation: 29
50	Istituto Giannina Gaslini	Liguria, Italy		Literature citation: 25