Top 50 Key Players companies in Lysosome by Highest Patent Value in the United States in 2018 – Discovery

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The Lysosome top 50 is Discovery PatSnap’ annual ranking of the top 50 Highest Patent Value Lysosome Key Players in the United States. Discovery has identified the top key players, startups & unicorns, fast-growings, news entrants in 2018, ranking from differnt perspectives, including patent filing intensity, academic research capability, news media heat. The company list is generated from various data types.

A lysosome (/ˈlaɪsəˌsoʊm/) is a membrane-bound organelle found in many animal cells. They are spherical vesicles that contain hydrolytic enzymes that can break down many kinds of biomolecules. A lysosome has a specific composition, of both its membrane proteins, and its lumenal proteins. The lumen's pH (~4.5–5.0) is optimal for the enzymes involved in hydrolysis, analogous to the activity of the stomach. Besides degradation of polymers, the lysosome is involved in various cell processes, including secretion, plasma membrane repair, cell signaling, and energy metabolism.

1	Synageva BioPharma Corp.	Massachusetts, United States	Botanical drug,Herb,Accelerated atherosclerosis, ...[+2]	Avg patent value: 8.58 M
2	Regents of the University of California	California, United States	Working capital,Pathology,Companion diagnostic, ...[+2]	Avg patent value: 8.50 M
3	Vertex Pharmaceuticals, Inc.	Massachusetts, United States	Health care,Medicine,Cystic fibrosis, ...[+2]	Avg patent value: 8.04 M
4	Alexion Pharmaceuticals, Inc.	Connecticut, United States	Health care,Biopharmaceutical,Clinical trial, ...[+2]	Avg patent value: 7.96 M
5	Shire Human Genetic Therapies, Inc.	Massachusetts, United States	Medicine	Avg patent value: 7.38 M
6	Seagen Inc.	Washington, United States	Antibody-drug conjugate,Medicine,Health care, ...[+2]	Avg patent value: 5.94 M
7	Wellstat Therapeutics Corp.	United States	Drug discovery,Pharmacy,Drug development, ...[+2]	Avg patent value: 5.74 M
8	Sangamo Therapeutics, Inc.	California, United States	Cell,Pharmacy and Therapeutics,Genomics, ...[+2]	Avg patent value: 5.61 M
9	BioMarin Pharmaceutical, Inc.	California, United States	Software development,Biopharmaceutical,Clinical trial, ...[+2]	Avg patent value: 5.44 M
10	Immunomic Therapeutics, Inc.	Pennsylvania, United States	Biology,Medicine,Pharmacy and Therapeutics, ...[+2]	Avg patent value: 4.79 M
11	Precigen, Inc.	United States	Cell therapy,Biology,Health care, ...[+2]	Avg patent value: 4.44 M
12	Riptide Bioscience, Inc.	United States	Colitis,Organism,Human body, ...[+2]	Avg patent value: 4.38 M
13	Genzyme Corp.	Massachusetts, United States	Medicine,Pharmacy and Therapeutics,Multiple sclerosis, ...[+2]	Avg patent value: 4.35 M
14	Celsion Corp.	New Jersey, United States	Immunotherapy,Pharmacy and Therapeutics,Health care, ...[+2]	Avg patent value: 3.95 M
15	Genentech, Inc.	California, United States	Biotechnology,Biology,Medicine, ...[+2]	Avg patent value: 3.76 M
16	Bayer Healthcare LLC	New Jersey, United States	Pharmaceutical medicine,Medicine,Computed tomography, ...[+2]	Avg patent value: 3.60 M
17	Bristol-Myers Squibb FCT bêta, Inc.	Texas, United States	Health care,Biological pathway,Biopharmaceutical, ...[+2]	Avg patent value: 3.15 M
18	UbiVac, Inc.	Oregon, United States	Immunotherapy,Medicine,Wellness Programs, ...[+2]	Avg patent value: 2.77 M
19	Amicus Therapeutics, Inc.	New Jersey, United States	Pharmacological chaperone,Medicine,Health care, ...[+2]	Avg patent value: 2.52 M
20	Sarepta Therapeutics, Inc.	Massachusetts, United States	Pharmacy and Therapeutics,Health care,Approved drug, ...[+2]	Avg patent value: 2.37 M
21	Massachusetts General Hospital	Massachusetts, United States	Substance abuse,Hospitality industry,Health care, ...[+2]	Avg patent value: 1.63 M
22	The General Hospital Corp.	Massachusetts, United States	Health care,Hospitality industry,Vascular Medicine, ...[+2]	Avg patent value: 1.63 M
23	REGENXBIO, Inc.	United States	Gene delivery,Viral vector,Pharmacy and Therapeutics, ...[+2]	Avg patent value: 1.53 M
24	ArmaGen, Inc.	California, United States	Health care,Iduronidase,Mucopolysaccharidosis, ...[+2]	Avg patent value: 1.07 M
25	Marker Gene Technologies, Inc.	Oregon, United States	Biotechnology,Microarray,Marker gene, ...[+2]	Avg patent value: 905,857
26	Rexahn Pharmaceuticals, Inc.	United States	Medicine,Medical equipment,Drug, ...[+2]	Avg patent value: 870,000
27	Ocuphire Pharma, Inc.	Michigan, United States	OPHTHALMIC DISORDERS,Glaucoma,Eye drop, ...[+2]	Avg patent value: 870,000
28	ChemGenes Corp.	Massachusetts, United States	Health care,RNA,DNA, ...[+2]	Avg patent value: 830,000
29	Regeneron Pharmaceuticals, Inc.	New York, United States	Monoclonal antibody,Clinical trial,Cholesterol, ...[+2]	Avg patent value: 800,624
30	Arrogene, Inc.	California, United States	Cancer,Medicine,Drug	Avg patent value: 760,000
31	Arrogene	California, United States	Glioma,Pre-clinical development,Cancer	Avg patent value: 760,000
32	Valerion Therapeutics LLC	Massachusetts, United States	Medicine,Pharmacy and Therapeutics,Alglucosidase alfa, ...[+2]	Avg patent value: 430,000
33	STARTUP Ligandal, Inc.	New York, United States	CRISPR,Coronavirus disease 2019 (COVID-19),Cell therapy, ...[+2]	Avg patent value: 160,000
34	Merck & Co., Inc.	New Jersey, United States	Health care,Biopharmaceutical,Drug, ...[+2]	Avg patent value: 150,000
35	Merck Sharp & Dohme Corp.	New Jersey, United States	Prescription drug,Medicine,Stroke, ...[+2]	Avg patent value: 150,000
36	Ambrx, Inc.	California, United States	Biology,Pharmacy and Therapeutics,Dosing Frequency, ...[+2]	Avg patent value: 150,000
37	STARTUP Prevail Therapeutics, Inc.	New York, United States	Gene,Health care,Pharmacy and Therapeutics, ...[+2]	Avg patent value: 139,638
38	Synpac (North Carolina), Inc.	North Carolina, United States		Avg patent value: 88,000
39	Denali Therapeutics, Inc.	California, United States	Biotechnology,Pharmacy and Therapeutics,Biological process, ...[+2]	Avg patent value: 87,625
40	STARTUP Astellas Gene Therapies, Inc.	California, United States	Health care,Gene,Biotechnology, ...[+2]	Avg patent value: 39,000
41	Orbis Health Solutions LLC	South Carolina, United States	Health care	Avg patent value: 38,000
42	Retrotope, Inc.	California, United States	Clinical trial,Health care,Degenerative disease, ...[+2]	Avg patent value: 31,000
43	Board of Regents of The University of Oklahoma	Oklahoma, United States	Radio broadcasting station,Radio broadcasting,Broadcasting	Avg patent value: 28,000
44	Applied Genetic Technologies Corp.	United States	Gene,Health care,Genomics, ...[+2]	Avg patent value: 17,000
45	M6P Therapeutics	Missouri, United States	Lysosomal storage disease,Gene,Enzyme	Avg patent value: 17,000
46	Asklepios BioPharmaceutical, Inc.	North Carolina, United States	Biopharmaceutical,Health care,Gene delivery, ...[+2]	Avg patent value: 15,850
47	Science & Technology Corp.	Virginia, United States	Space Science,Aerospace engineering,Systems engineering, ...[+1]	Avg patent value: 4,000
48	Pfizer Inc.	New York, United States	Health care,Clinical trial,Drug, ...[+2]	Avg patent value: 0
49	Bristol Myers Squibb Co.	New York, United States	Medicine,Health care,Oncology drugs, ...[+2]	Avg patent value: 0
50	Alnylam Pharmaceuticals, Inc.	Massachusetts, United States	RNA interference,Medicine,Health care, ...[+2]	Avg patent value: 0