Top 50 Key Players companies in Lysosome by Most Patent Filings in the United States in 2022 – Discovery

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The Lysosome top 50 is Discovery PatSnap’ annual ranking of the top 50 Most Patent Filings Lysosome Key Players in the United States. Discovery has identified the top key players, startups & unicorns, fast-growings, news entrants in 2022, ranking from differnt perspectives, including patent filing intensity, academic research capability, news media heat. The company list is generated from various data types.

A lysosome (/ˈlaɪsəˌsoʊm/) is a membrane-bound organelle found in many animal cells. They are spherical vesicles that contain hydrolytic enzymes that can break down many kinds of biomolecules. A lysosome has a specific composition, of both its membrane proteins, and its lumenal proteins. The lumen's pH (~4.5–5.0) is optimal for the enzymes involved in hydrolysis, analogous to the activity of the stomach. Besides degradation of polymers, the lysosome is involved in various cell processes, including secretion, plasma membrane repair, cell signaling, and energy metabolism.

1	BioMarin Pharmaceutical, Inc.	California, United States	Software development,Biopharmaceutical,Clinical trial, ...[+2]	Patent: 150
2	Shire Human Genetic Therapies, Inc.	Massachusetts, United States	Medicine	Patent: 150
3	Genzyme Corp.	Massachusetts, United States	Medicine,Pharmacy and Therapeutics,Multiple sclerosis, ...[+2]	Patent: 106
4	Amicus Therapeutics, Inc.	New Jersey, United States	Pharmacological chaperone,Medicine,Health care, ...[+2]	Patent: 97
5	STARTUP Prevail Therapeutics, Inc.	New York, United States	Gene,Health care,Pharmacy and Therapeutics, ...[+2]	Patent: 56
6	Regeneron Pharmaceuticals, Inc.	New York, United States	Monoclonal antibody,Clinical trial,Cholesterol, ...[+2]	Patent: 42
7	Alexion Pharmaceuticals, Inc.	Connecticut, United States	Health care,Biopharmaceutical,Clinical trial, ...[+2]	Patent: 28
8	Synageva BioPharma Corp.	Massachusetts, United States	Botanical drug,Herb,Accelerated atherosclerosis, ...[+2]	Patent: 21
9	Photocure ASA	New Jersey, United States	Photodynamic diagnosis,Medicine,Lifestyle drug, ...[+2]	Patent: 19
10	Sarepta Therapeutics, Inc.	Massachusetts, United States	Pharmacy and Therapeutics,Health care,Approved drug, ...[+2]	Patent: 18
11	Asklepios BioPharmaceutical, Inc.	North Carolina, United States	Biopharmaceutical,Health care,Gene delivery, ...[+2]	Patent: 14
12	Bayer Healthcare LLC	New Jersey, United States	Pharmaceutical medicine,Medicine,Computed tomography, ...[+2]	Patent: 13
13	Sangamo Therapeutics, Inc.	California, United States	Cell,Pharmacy and Therapeutics,Genomics, ...[+2]	Patent: 12
14	ALZA Corp.	California, United States	Health care,Pharmacy and Therapeutics,Medical product, ...[+2]	Patent: 12
15	Merck & Co., Inc.	New Jersey, United States	Health care,Biopharmaceutical,Drug, ...[+2]	Patent: 11
16	Bristol-Myers Squibb FCT bêta, Inc.	Texas, United States	Health care,Biological pathway,Biopharmaceutical, ...[+2]	Patent: 11
17	Denali Therapeutics, Inc.	California, United States	Biotechnology,Pharmacy and Therapeutics,Biological process, ...[+2]	Patent: 10
18	Bristol Myers Squibb Co.	New York, United States	Medicine,Health care,Oncology drugs, ...[+2]	Patent: 9
19	Rexahn Pharmaceuticals, Inc.	United States	Medicine,Medical equipment,Drug, ...[+2]	Patent: 9
20	Bristol Myers Co.	New York, United States	Botanical drug,Herb	Patent: 9
21	Q Therapeutics, Inc.	Utah, United States	Medicine,Health care,Pharmacy and Therapeutics, ...[+2]	Patent: 8
22	STARTUP Ligandal, Inc.	New York, United States	CRISPR,Coronavirus disease 2019 (COVID-19),Cell therapy, ...[+2]	Patent: 8
23	StemCells California, Inc.	California, United States		Patent: 8
24	Merck Sharp & Dohme Corp.	New Jersey, United States	Prescription drug,Medicine,Stroke, ...[+2]	Patent: 7
25	Valerion Therapeutics LLC	Massachusetts, United States	Medicine,Pharmacy and Therapeutics,Alglucosidase alfa, ...[+2]	Patent: 7
26	Marker Gene Technologies, Inc.	Oregon, United States	Biotechnology,Microarray,Marker gene, ...[+2]	Patent: 7
27	Vertex Pharmaceuticals, Inc.	Massachusetts, United States	Health care,Medicine,Cystic fibrosis, ...[+2]	Patent: 6
28	Medtronic, Inc.	Minnesota, United States	Medicine,Implantable cardiac pacemaker,Biomedical engineering, ...[+2]	Patent: 6
29	Pharmacia Corp.	New Jersey, United States	Botanical drug,Herb,Ophthalmology, ...[+2]	Patent: 6
30	Massachusetts General Hospital	Massachusetts, United States	Substance abuse,Hospitality industry,Health care, ...[+2]	Patent: 6
31	Maxygen, Inc.	California, United States	Directed evolution,DNA shuffling,Molecular breeding, ...[+2]	Patent: 6
32	The General Hospital Corp.	Massachusetts, United States	Health care,Hospitality industry,Vascular Medicine, ...[+2]	Patent: 6
33	Immunomic Therapeutics, Inc.	Pennsylvania, United States	Biology,Medicine,Pharmacy and Therapeutics, ...[+2]	Patent: 6
34	Neuraltus Pharmaceuticals, Inc.	California, United States	Fabry's disease,Medicine,Health care, ...[+2]	Patent: 6
35	Biocept, Inc.	California, United States	Health care,Circulating tumor DNA,Circulating tumor cell, ...[+2]	Patent: 5
36	STARTUP Lycia Therapeutics, Inc.	California, United States	Biotechnology,Health care,Biology	Patent: 5
37	Virginia Tech Intellectual Properties, Inc.	Virginia, United States	Software,Medical imaging,Digital library, ...[+2]	Patent: 5
38	Applied Genetic Technologies Corp.	United States	Gene,Health care,Genomics, ...[+2]	Patent: 4
39	PRP LLC	District of Columbia, United States	Alternative investment,Asset management	Patent: 4
40	Arrogene, Inc.	California, United States	Cancer,Medicine,Drug	Patent: 4
41	Ambrx, Inc.	California, United States	Biology,Pharmacy and Therapeutics,Dosing Frequency, ...[+2]	Patent: 4
42	UbiVac, Inc.	Oregon, United States	Immunotherapy,Medicine,Wellness Programs, ...[+2]	Patent: 4
43	Kentucky BioProcessing LLC	Kentucky, United States	American tobacco,Chemical engineering	Patent: 4
44	Arrogene	California, United States	Glioma,Pre-clinical development,Cancer	Patent: 4
45	Research Development Foundation	United States	Plasmid,Molecular medicine,Cardiovascular agent, ...[+2]	Patent: 4
46	Ixsys, Inc.	California, United States	Software,Human resource management,Payroll	Patent: 4
47	Enzon Pharmaceuticals, Inc.	New Jersey, United States	Medicine,Health care,PEGylation, ...[+2]	Patent: 3
48	Roche Diagnostics Corp.	Indiana, United States	Medicine,Urinalysis,Immunoassay, ...[+2]	Patent: 3
49	Board of Regents of The University of Oklahoma	Oklahoma, United States	Radio broadcasting station,Radio broadcasting,Broadcasting	Patent: 3
50	ArmaGen, Inc.	California, United States	Health care,Iduronidase,Mucopolysaccharidosis, ...[+2]	Patent: 3