Top 50 Key Players companies in Proline by Highest Patent Value in the United States in 2022 – Discovery

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The Proline top 50 is Discovery PatSnap’ annual ranking of the top 50 Highest Patent Value Proline Key Players in the United States. Discovery has identified the top key players, startups & unicorns, fast-growings, news entrants in 2022, ranking from differnt perspectives, including patent filing intensity, academic research capability, news media heat. The company list is generated from various data types.

Proline (symbol Pro or P) is a proteinogenic amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated NH₂⁺ form under biological conditions), an α-carboxylic acid group (which is in the deprotonated −COO⁻ form under biological conditions), and a side chain pyrrolidine, classifying it as a nonpolar (at physiological pH), aliphatic amino acid. It is non-essential in humans, meaning the body can synthesize it from the non-essential amino acid L-glutamate. It is encoded by all the codons starting CC (CCU, CCC, CCA, and CCG).

1	ArQule, Inc.	Massachusetts, United States	Pharmacy and Therapeutics,Biotechnology,Oncology drugs, ...[+2]	Avg patent value: 10.54 M
2	Kirin-Amgen, Inc.	California, United States	Pharmaceutical drug,Medicine	Avg patent value: 10.17 M
3	PPG Industries, Inc.	Pennsylvania, United States	Coating,Chemical engineering,Industrial engineering, ...[+2]	Avg patent value: 9.69 M
4	PPG Industries Ohio, Inc.	Ohio, United States	Coating,Industrial engineering,Metal fiber, ...[+2]	Avg patent value: 9.69 M
5	Seagen Inc.	Washington, United States	Antibody-drug conjugate,Medicine,Health care, ...[+2]	Avg patent value: 9.59 M
6	STARTUP Viela Bio, Inc.	United States	B cell,Immunotherapy,Biotechnology, ...[+2]	Avg patent value: 8.71 M
7	GlobeImmune, Inc.	Colorado, United States	Cancer,Medicine,Health care, ...[+2]	Avg patent value: 8.49 M
8	Promega Corp.	Wisconsin, United States	Enzyme,Journalism,Biology, ...[+2]	Avg patent value: 8.39 M
9	Enanta Pharmaceuticals, Inc.	Massachusetts, United States	Medicine,Health care,Protease, ...[+2]	Avg patent value: 7.91 M
10	Arcellx, Inc.	United States	Medicine,Cell therapy,Cell, ...[+2]	Avg patent value: 7.64 M
11	Regeneron Pharmaceuticals, Inc.	New York, United States	Monoclonal antibody,Clinical trial,Cholesterol, ...[+2]	Avg patent value: 7.15 M
12	CARA Therapeutics, Inc.	Connecticut, United States	Analgesic,Medicine,Health care, ...[+2]	Avg patent value: 6.15 M
13	Janssen Global Services LLC	California, United States	Medicine,Pharmacy and Therapeutics,Viral disease, ...[+2]	Avg patent value: 6.08 M
14	Janssen BioPharma LLC	California, United States		Avg patent value: 6.08 M
15	DePuy Synthes Products, Inc.	Delaware, United States	Medical equipment,Medicine,Pressure sensor, ...[+2]	Avg patent value: 5.82 M
16	Helix BioMedix, Inc.	Washington, United States	Peptide,Medical equipment,Medicine, ...[+2]	Avg patent value: 5.77 M
17	Gilead Sciences, Inc.	California, United States	Medicine,Health care,Biopharmaceutical, ...[+2]	Avg patent value: 5.32 M
18	Wyeth LLC	New Jersey, United States		Avg patent value: 4.86 M
19	Soligenix, Inc.	New Jersey, United States	Biodefense,Medicine,Health care, ...[+2]	Avg patent value: 4.86 M
20	Genentech, Inc.	California, United States	Biotechnology,Biology,Medicine, ...[+2]	Avg patent value: 4.73 M
21	Sarepta Therapeutics, Inc.	Massachusetts, United States	Pharmacy and Therapeutics,Health care,Approved drug, ...[+2]	Avg patent value: 4.62 M
22	Amunix Pharmaceuticals, Inc.	California, United States	Half-life,Conjugate,Medicine, ...[+2]	Avg patent value: 4.62 M
23	The Dow Chemical Co.	Michigan, United States	Coating,Agriculture,Chemical engineering, ...[+2]	Avg patent value: 4.55 M
24	Los Alamos National Security LLC	New Mexico, United States	National security	Avg patent value: 4.30 M
25	Abbott Molecular, Inc.	Illinois, United States	Medical equipment,Health care,Molecular diagnostics, ...[+2]	Avg patent value: 4.03 M
26	Medimmune, Inc.	United States	Botanical drug,Herb	Avg patent value: 3.81 M
27	Galen Bio, Inc.	United States		Avg patent value: 3.79 M
28	Altrubio, Inc.	California, United States	E-commerce,Shopping mall,Immune checkpoint, ...[+2]	Avg patent value: 3.64 M
29	Triad National Security LLC	Ohio, United States		Avg patent value: 3.53 M
30	Amgen, Inc.	California, United States	Health care,Biopharmaceutical,TUMOR NECROSIS FACTOR BLOCKER, ...[+2]	Avg patent value: 3.44 M
31	Colgate-Palmolive Co.	New York, United States	Toothpaste,Dental floss,Fast-moving consumer goods, ...[+2]	Avg patent value: 3.09 M
32	Purdue Pharma LP	Connecticut, United States	Opioid,Medicine,Opioid epidemic, ...[+2]	Avg patent value: 3.02 M
33	Purdue Pharma, Inc.	Connecticut, United States	Health care,Healthcare system,Educational program, ...[+1]	Avg patent value: 3.02 M
34	Bristol Myers Squibb Co.	New York, United States	Medicine,Health care,Oncology drugs, ...[+2]	Avg patent value: 2.89 M
35	Bristol Myers Co.	New York, United States	Botanical drug,Herb	Avg patent value: 2.89 M
36	Procter & Gamble Co.	Ohio, United States	Toothpaste,Hair conditioner,SOAP, ...[+2]	Avg patent value: 2.88 M
37	Aduro Biotech Holdings Europe BV	California, United States	Antibody,Medicine,Biotechnology, ...[+2]	Avg patent value: 2.79 M
38	Codexis, Inc.	California, United States	Enzyme,Chemical engineering,Biocatalysis, ...[+2]	Avg patent value: 2.47 M
39	bioMérieux, Inc.	North Carolina, United States	Medicine,Nucleic acid test,Blood Screening, ...[+2]	Avg patent value: 2.45 M
40	Exoxemis, Inc.	Arkansas, United States	Health care,Haloperoxidase,Normal flora, ...[+2]	Avg patent value: 2.42 M
41	Pfizer Inc.	New York, United States	Health care,Clinical trial,Drug, ...[+2]	Avg patent value: 2.21 M
42	REG Life Sciences LLC	California, United States	Chemical engineering,Biopesticide,Pesticide, ...[+1]	Avg patent value: 2.07 M
43	Smithkline Beckman Corp	Pennsylvania, United States	Biotechnology,Medicine	Avg patent value: 1.69 M
44	Mars, Inc.	Virginia, United States	Food products,Fast-moving consumer goods,Food industry, ...[+2]	Avg patent value: 1.49 M
45	Mary Kay, Inc.	Texas, United States	Cosmetics,Skin care,Sales management, ...[+2]	Avg patent value: 1.34 M
46	Eolas Therapeutics, Inc.	California, United States	Addiction,Pharmacy and Therapeutics,Nicotine, ...[+2]	Avg patent value: 1.29 M
47	Bayer CropScience LP	North Carolina, United States	Pesticide,Agriculture,Crop, ...[+2]	Avg patent value: 1.03 M
48	Ambrx, Inc.	California, United States	Biology,Pharmacy and Therapeutics,Dosing Frequency, ...[+2]	Avg patent value: 1.00 M
49	Elanco US, Inc.	Indiana, United States	Health care,Animal welfare,Drug, ...[+1]	Avg patent value: 1.00 M
50	3-D Matrix, Inc.	Massachusetts, United States	Health care,Self-assembling peptide,Wound healing, ...[+2]	Avg patent value: 934,000