Chronic Pain Syndrome is a common problem that is a major challenge to health-care providers because of its complex nature of poor etiology and poor response to therapy. Most consider ongoing pain of 3~6 months are diagnostic. A person may have two or more co-existing pain conditions or widespread generalized pain. This condition is managed best with a multidisciplinary approach. Although CPS has been known to resolve completely with treatment, it is uncommon for full relief to be achieved. Therefore, patients should be encouraged to develop realistic goals for their pain treatment. Medications, surgeries, and alternative medicine treatments can reduce pain although their effectiveness varies by the patient and some may provide no relief at all to certain individuals. Occasionally CPS may become increasingly more painful over time regardless of attempted treatments. The prognosis is best for patients who begin pain treatment within 6 months of the onset of symptoms, after which the chance of remission plateaus at a very low level.