Defibrillation threshold indicates the minimum amount of energy needed to return normal rhythm to a heart that is beating in a cardiac dysrhythmia. Typical examples are the minimum amount of energy, expressed in joules, delivered by external defibrillator paddles or pads, required to break atrial fibrillation and restore normal sinus rhythm. Other common scenarios are restoring normal rhythm from atrial flutter, ventricular tachycardia or ventricular fibrillation. The defibrillation threshold ranking in these settings, from lowest to highest, would be, in order, ventricular tachycardia, atrial flutter, atrial fibrillation, ventricular fibrillation. The highest amount of energy that an external defibrillator can deliver at the present time is 360 joules biphasic. In clinical practice, the real threshold can be approximated but not exactly established, since the defibrillating shock can be delivered only once. Certain medications, in particular sotalol, tend to lower such threshold, while others, such as amiodarone, may increase it.
Cardiac Pacemakers, Inc.(CPI), doing business as Guidant Cardiac Rhythm Management, manufactured implantable cardiac rhythm management devices, such as pacemakers and defibrillators. It also sold insulin pumps controlled by microprocessors and various equipments to regulate heart rhythm. In addition, Cardiac Pacemakers, Inc. developed therapies for the treatment of irregular heartbeats. The company was founded in 1971 and is based in St. Paul, Minnesota. Cardiac Pacemakers, Inc. operates as a subsidiary of Boston Scientific Corporation.
Medical equipment
Insulin pump
Insulin
Microprocessor
Pacesetter, Inc., a subsidiary of Abbott Laboratories, is a company headquartered in the United States that manufactures, and distributes cardiovascular and implantable neuro stimulation medical devices.
Medtronic, Inc.
http://www.medtronic.com
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Medtronic, Inc. operates as a medical technology company. It offers implantable cardiac pacemakers, eternal defibrillators, inferior turbinate surgery products, and continuous glucose monitoring device. The company was founded by Earl E. Bakken and Palmer J. Hermundslie on April 29, 1949 and is headquartered in Minneapolis, MN.
Medicine
Implantable cardiac pacemaker
Biomedical engineering
Medical equipment
Surgery
Biocompatible material
Infusion pump
Spinal cord stimulator
Neurology
Spinal cord
ELECTROSURGICAL DEVICE
Deep brain stimulator
Brain–computer interface
Syringe
Sewing needle
Biosensor
Traumatic brain injury
Neurological disorder
Operating room equipment
Blood glucose monitoring
Develops and markets complex devices for treating malfunctions of the heart
ZOLL Medical Corp. develops and markets medical devices and related software solutions for emergency care. It provides products for defibrillation and monitoring, circulation and CPR feedback, data management, fluid resuscitation, and therapeutic temperature management. The firm provides technologies which help fire professionals, clinicians, and rescuers in providing critical care and resuscitation treatment. It also designs software that automates data documentation and management for both clinical and non-clinical information. The company was founded by William Bright, Rolf S. Stutz, Paul M. Zoll, Leigh Stein, and Thomas M. Claflin in 1980 and is headquartered in Chelmsford, MA.
UAB Research Foundation
http://www.uab.edu/innovation/about
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UAB Research Foundation (doing business as UABRF), a subsidiary of The University of Alabama System, is a company headquartered in Birmingham, AL. The firm engages in identify, assess, and market commercially viable technology developed at The University of Alabama at Birmingham.
Biotechnology
Agriculture
Fishery
Nanotechnology
Pharmacy
Biology
Botany
Chemistry
Medicine
Oceanography
Angeion Corp develops, manufactures and markets non-invasive cardiorespiratory diagnostic systems.
Ventritex, Inc. designs, develops, manufactures and markets implantable defibrillators and related products for the treatment of ventricular tachycardia and ventricular fibrillation.
Medicine
Implantable defibrillators
Ventricular tachycardia
Cadence
Schiller Medical SAS manufactures equipment of medical irradiation, electro medical and electrotherapeutic equipment. The company was founded in 1977 and is headquartered in Wissembourg, France
BIOTRONIK SE & Co. KG
http://www.biotronik.com
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Biotronik (Biotronik SE & Co. KG; Biotronik Worldwide) is a privately held multinational biomedical technology company headquartered in Berlin, Germany. The company offers complete solutions for diagnosis, treatment, and therapy support in the areas of cardiac rhythm management, electrophysiology and vascular intervention. In the area of cardiac rhythm management, Biotronik Home Monitoring® uses telemonitoring technology to provide doctors with up-to-date information for implant patients.
Biomedical technology
Medical equipment
Implantable cardioverter-defibrillator
Electrophysiology
Stent
Coronary stent
Implant
Bioabsorbable stent
Drug-eluting stent
Bare-metal stent
Catheter
Implantable loop recorder
Cardiology
Cardiac monitoring
Holter monitor
Telemetry
Heart valve
Angioplasty balloon
Atherectomy device
Morgan Technologies Incorporated
Koninklijke Philips NV is a technology company, which engages in the healthcare, lighting, and consumer well-being markets. It operates through the following segments: Diagnosis and Treatment businesses; Connected Care businesses; Personal Health businesses; and Other. The Diagnosis and Treatment businesses segment consists systems, smart devices, software and services, powered by AI-enabled informatics-that support precision diagnoses and minimally invasive procedures in therapeutic areas such as cardiology, peripheral vascular, neurology, surgery, and oncology. The Connected Care businesses segment consists Hospital Patient Monitoring, Emergency Care, Sleep & Respiratory Care and Connected Care Informatics. The Personal Health businesses segment consists of Oral Healthcare, Personal Care,Mother and Child Care. The Other segment reports on the items Innovation & Strategy, IP Royalties, Central costs, and other small items. The company was founded by Anton Frederik Philips and Gerard Leonard Frederik Philips in 1891 and is headquartered in Amsterdam, the Netherlands.
Medical imaging
Ultrasound
Image-Guided Therapy
Disease Pathway
Invasive treatments
Workflow optimization
Materials science
Informatics
Computer science
Medical ventilator
Optics
Optoelectronics
Nebulizer
Electronic engineering
Regents of The University of Michigan
http://www.regents.umich.edu
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Regents of The University of Michigan provides administers bonds on behalf of the University. The company is headquartered in Ann Arbor, MI.
Philips Electronics North America Corp.
https://www.usa.philips.com/healthcare
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Philips Healthcare provides healthcare solutions for diagnostic, treatment, and preventive care. The company’s product portfolio includes CT scanners, ECG equipment, mammography equipment, monitoring equipment, MRI scanners, radiography equipment, resuscitation equipment, ultrasound equipment, molecular imaging devices, X-ray equipment, and more.
Philips Healthcare has focused their research and development efforts to develop new approaches in the areas of radiology, cardiology, oncology, decision support, home health, respiratory and other critical areas.
Philips Healthcare is a division of Philips, a Dutch diversified technology company that offers consumer electronics and electrical products. The mother company was established in 1891 by Gerard Philips and his father Frederik Philips.
Electronics
Toothbrush
DVD player
Ultrasound
Peripheral
Exelixis is focused on discovering, developing and commercializing therapies for the treatment of cancer and other serious diseases. The majority of its programs focus on the discovery and development of small molecule drugs for cancer. The Company has a pipeline of compounds in various stages of development for the treatment of cancer and various metabolic, cardiovascular and inflammatory disorders. All of its development compounds were generated through its internal drug discovery activities, although it is developing certain of these compounds in collaboration with partners and has out-licensed to others. The Company is focusing its development activities on its clinical compounds, XL184, XL147 and XL765. XL184, the Company's advanced drug candidate, inhibits MET, VEGFR2 and RET, proteins that are key drivers of tumor growth and/or vascularization. XL147 is a selective inhibitor of PI3K while XL765 is a dual inhibitor of PI3K and mTOR.
Oncology drugs
Drug
Inflammatory disorder
Drug discovery
Clinical trial
Small molecule
Cancer
Bevacizumab
Immunotherapy
Renal cell carcinoma
Trametinib
Biotechnology
Monoclonal antibody
Biomedicine
Merkel cell carcinoma
Antibody-drug conjugate
Pazopanib
Sunitinib
Doxorubicin
Board of Regents of The University of Oklahoma
Board of Regents of The University of Oklahoma is a private company headquartered in Norman, OK, with domestic subsidiaries, specializing in radio broadcasting stations.
Radio broadcasting station
Radio broadcasting
Broadcasting
Physio-Control, Inc.
http://www.physio-control.com
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Physio-Control, Inc. provides professional emergency medical response solutions that predict or intervene in life-threatening emergencies. Its products include LIFEPAK monitor/defibrillators and automated external defibrillators (AED), LUCAS Chest Compression Systems, the LIFENET System and HeartSine AEDs. The company was founded by Karl William Edmark in 1955 and is headquartered in Redmond, WA.
Implantable cardioverter-defibrillator
mHealth
Medical imaging
Resuscitation
Implantable loop recorder
Clinical skills
Resuscitator
Tracheal tube
Picture archiving and communication system
Medical ventilator
Holographic imaging
Molecular imaging
Biosensor
Regents of the University of California
The University of California is the nation's best public university system, delivering top-notch research and innovation to California (and the world).
Pathology
Companion diagnostic
Eli Lilly engages in the discovery, development, manufacture, and sale of products in the pharmaceutical products business segment. The company manufactures and distributes products through owned or leased facilities in the United States, Puerto Rico, and 25 other countries. Its products are sold in approximately 135 countries. It also conducts research to find products to treat diseases in animals and to increase the efficiency of animal food production.
Medicine
Humalog Mix
Major depressive disorder
Breast cancer
Insulin
Clinical trial
Oncology drugs
Insulin pen
Idiopathic short stature
Insulin aspart
Generalized anxiety disorder
Bipolar I disorder
Peripheral neuropathic pain
Bulimia nervosa
Panic disorder
Growth hormone deficiency
Endocrinology
Fibromyalgia
Monoclonal antibody
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