Lundbeck is a global pharmaceutical company highly committed to improving the quality of life of people living with psychiatric and neurological disorders. For this purpose, Lundbeck is engaged in the research, development, production, marketing, and sale of pharmaceuticals across the world. The company’s products are targeted at disease areas such as depression, schizophrenia, Parkinson’s disease, and Alzheimer’s disease. According to the World Health Organization, WHO, more than 700 million cases of psychiatric and neurological disorders are reported every year. These are serious and life-threatening diseases that affect the quality of life of the patients as well as of their relatives. As these diseases also involve major socio-economic costs, it is imperative for the general society that new and innovative pharmaceuticals are developed. Over the past 50 years, new pharmaceuticals have revolutionized the treatment options, but there remains a large unmet need for new and innovative therapeutics. Focus on R&D is the most important pillar in Lundbeck’s ambition to improve treatment for people living with psychiatric and neurological disorders. We are specialists in our area and have research facilities in Denmark and China, and more than 1,000 employees work in our R&D units. We cooperate closely with strategic partners all over the world, ensuring the best possible foundation for innovation and the development of new treatment solutions. Lundbeck employs approximately 5,300 people worldwide, 1,700 of whom are based in Denmark. We have employees in 55 countries, and our products are registered in more than 100 countries. We have production facilities in China, Denmark, France and Italy and research centers in Denmark and China.

Glaxo Group Ltd. operates through its subsidiary Glaxo Laboratories Ltd. that engages in the production of food products for infants such as Ostermilk, Complan, Casilan, Farex. Glaxo Group Ltd. was formerly known as Glaxo Laboratories Ltd. and changed its name to Glaxo Group Ltd. in 1962. The company is based in Brentford, United Kingdom. Glaxo Group Ltd. operates as a subsidiary of Glaxosmithkline plc.

Organon Pharma (UK) Ltd. develops and manufactures pharmaceuticals. It offers osteoarthritis pain treatment Arcoxia, cardiovascular medication Cozaar, HIV drug Crixivan and asthma treatment Singulair. It operates a research center specializing in the development of central nervous system disorder such as Alzheimer's disease, depression, anxiety and migrane. The company was founded in 1953 and is headquartered in Hoddesdon, the United Kingdom.

Richter Gedeon Nyrt deals with pharmaceutical production, research and development, trade, and marketing.

Part of Sanofi, Aventis Pharma SARL is a French company located in Antony. The firm manufactures pharmaceuticals. It was founded in 1982.

Astellas Pharma Inc. is a Japan-based pharmaceutical company that operates its business in more than 70 countries around the world. It has approximately 16,000 employees, and its core products include anticancer agents like XTANDI, XOSPATA, and PADCEV; Betanis / Myrbetriq / BETMIGA for the treatment of overactive bladder (OAB); and Prograf, an immunosuppressant for organ transplantation. In its FY2019 financial results, revenue achieved about 1,300 billion yen (ca.$12 billion*), and R&D expenses were about 220 billion yen (ca.$1.9 billion*). Astellas' competitiveness comes from its own innovativeness in R&D and extensive network featuring cutting-edge technology garnered through proactive collaborations with academia, bio-ventures, and pharmaceutical companies worldwide. Its R&D activities are managed and promoted by functional centers in the U.S., Japan, and Asia, which enhance agility and efficiency of projects through parallel developments globally. Astellas established the “Focus Area Approach” as its R&D strategy. This approach focuses on building sustainable and expandable drug discovery by selecting the best combination of biology, modality/technology, and disease. The company has identified four prioritized research areas, Blindness & Regeneration, Mitochondria Biology, Genetic Regulation, Immuno-Oncology, named “Primary Focus” where it focuses its resource to strategically expand its pipeline. One of the Astellas’ key focuses that support the strategy is collaborations with academic labs and various pharmaceutical companies, including start-ups. Dedicated teams have been assigned to maximize the value of respective collaborations. These include Astellas Innovation Management, which promotes intaking early-stage innovations, Business Development, which identifies opportunities for inward/outward transactions and executes deals and manages subsequent alliances, and Astellas Venture Management, a corporate venture capital that makes private equity investments in early-stage biotech start-ups in an attempt to potentially reinforce Astellas’ pipeline. In drug discovery activities, the R&D pipeline programs have been reinforced by incorporating external cutting-edge science. In recent years in particular, advanced technologies in areas such as cell therapy and genetic regulation have been added to Astellas’ capabilities. Astellas has also been successful in M&As, including Audentes Therapeutics, Xyphos Biosciences, Nanna Therapeutics, Universal Cells, Ocata Therapeutics, and Mitobridge for unique scientific features. Astellas has demonstrated a strong footprint in late-stage clinical trials and commercialization of its strategic products. In the past three years, it successfully launched three new products (XOSPATA, Evrenzo and PADCEV) and expanded indications of XTANDI worldwide by realizing excellent management of each clinical trial program. Astellas also achieved annual sales of 754.5 billion yen (ca.$6.9 billion*) with XTANDI, Betanis / Myrbetriq / BETMIGA, and Prograf in FY2019 with a strong focus on delivering value through improving patient access and outcomes in the associated therapy areas. Another remarkable approach that Astellas is taking is creating new healthcare solutions beyond medicine based on the existing expertise and knowledge in its Rx business, combined with adjacent technologies from partners. Astellas values research outcomes from all partners and is willing to realize untapped value thereof by collaborating with a partner and maximizing the value of assets by using Astellas’ capability (e.g., funding, facilities, human resources, and know-how). Openness and flexibility in designing alliance mechanisms (e.g. tailored joint study programs and financial arrangements) will help the parties to realize executing a deal in a timely manner. Astellas is committed to creating medical solutions in order to turn innovative science into value for patients and incorporating capabilities of partners. *The exchange rate for the yen, 1USD: 109yen

F. Hoffmann-La Roche Ltd. manufactures pharmaceutical products. It offers pharmaceutical drugs, pharmaceutical instruments, and diagnostics solutions. The company was founded by Fritz Hoffmann-La Roche on October 1, 1896 and is headquartered in Basel, Switzerland.

Janssen Pharmaceutica is a pharmaceutical company headquartered in Beerse, Belgium and owned by Johnson & Johnson. It was founded in 1953 by Paul Janssen. In 1961, Janssen Pharmaceutica was purchased by New Jersey-based American corporation Johnson & Johnson, and became part of Johnson & Johnson Pharmaceutical Research and Development (J&J PRD), now renamed to Janssen Research and Development (JRD), which conducts research and development activities related to a wide range of human medical disorders, including mental illness, neurological disorders, anaesthesia and analgesia, gastrointestinal disorders, fungal infection, HIV/AIDS, allergies and cancer. Janssen and Ortho-McNeil Pharmaceutical have been placed in the Ortho-McNeil-Janssen group within Johnson & Johnson Company.

VeroScience LLC develops and markets biotechnology and healthcare products. The firm also develops novel, practical, and effective therapies for chronic debilitating human diseases such as Type 2 diabetes, metabolic syndrome, autoimmune disease, and cancer through interdisciplinary basic research. The company was founded by Anthony H. Cincotta in 2001 and is headquartered in Tiverton, RI.

Pfizer Inc. (NYSE: PFE, /ˈfaɪzər/) is an American multinational pharmaceutical corporation headquartered in New York City was founded in 1849, based in New York City and was listed on New York Stock Exchange. It is one of the world's largest pharmaceutical companies. It is listed on the New York Stock Exchange, and its shares have been a component of the Dow Jones Industrial Average since 2004. Pfizer ranked No. 57 on the 2018 Fortune 500 list of the largest United States corporations by total revenue.

Smithkline Beecham Plc develops and manufactures pharmaceutical products. The company markets pharmaceuticals for human and animal healthcare consumption, vaccines, over the counter medicines, health related consumer products, clinical laboratory testing services, disease management and pharmaceutical benefit management. It is headquartered in Brentford, UK.

Part of Indivior PLC, Indivior UK Ltd. is a company headquartered in Hull, UK, that manufactures and distributes pharmaceutical products. It was founded in 2010.

Shandong Luye Pharmaceutical Co., Ltd. researches, develops, produces, and sells pharmaceutical drugs. The company was founded on June 8, 1994 and is headquartered in Yantai, China.

Intra-Cellular Therapies (ITI) is developing novel drugs for the treatment of neuropsychiatric and neurologic diseases and other disorders of the Central Nervous System (CNS). We combine the efforts of medicinal chemists, pharmacologists, biologists and clinical development scientists into a vibrant team that translates world-class research expertise into novel drugs. The company's lead product, ITI-007 is a novel first-in-class 5-HT2A antagonist, Dopamine receptor phosphoprotein modulator (DPPM) designed to treat multiple deficits in patients with schizophrenia while lacking the side-effects of existing antipsychotic drugs. ITI has also developed a state of the art technology platform, called CNSProfile™ that is capable of generating a unique molecular signature for drug compounds. This profile provides us with a proprietary window into the intracellular action of CNS drugs or drug candidates. We use this tool to fingerprint the intracellular molecular actions of existing drugs and to drive our internal drug discovery and development. Our technology has also enabled the company to examine the toxic effects of brain damaging nerve agents, and as a result, we are involved in collaborative efforts with several military and contract organizations to develop antidotes to chemical warfare agents. Based upon our understanding of the Central Nervous System we have discovered novel drug candidates with promise for treating the panoply of symptoms associated with the transition from peri-menopausal to post-menopausal states. Intra-Cellular Therapies was founded in 2002 by Drs. Paul Greengard, Sharon Mates and Allen Fienberg. The company is headquartered in New York City.

Pharmacopeia, Inc., a biopharmaceutical company, engages in the discovery and development of therapeutics to address significant medical needs. Its internal program portfolio comprises PS433540, a dual-acting angiotensin and endothelin receptor antagonist, which is in phase II clinical development for the treatment of cardiovascular and renal diseases, including hypertension and diabetic nephropathy; and PS178990, a muscle selective SARM agonists that is in phase I clinical development. The company's products also include PS031291, a preclinical development product for the treatment of multiple myeloma and various inflammatory diseases, including rheumatoid arthritis; and JAK3 inhibitors for T-cell and cytokine mediated dermatologic and ocular diseases, such as psoriasis and dry eye. Pharmacopeia has strategic alliances with Bristol-Myers Squibb, Celgene, Cephalon, GlaxoSmithKline, Schering-Plough, and Wyeth Pharmaceuticals. The company was founded in 1993. It was formerly known as Pharmacopeia Drug Discovery, Inc. and changed its name to Pharmacopeia, Inc. in May 2007. Pharmacopeia is based in Cranbury, New Jersey. As of December 23, 2008, Pharmacopeia, Inc. operates as a subsidiary of Ligand Pharmaceuticals Inc.

Pharmacia & Upjohn Co. LLC, a subsidiary of Pfizer Inc., is a company headquartered in Bingham Farms, MI, that manufactures and supplies pharmaceutical goods.

Smithkline Beckman Corp, part of GSK Plc, is an American company located in Philadelphia, PA, involved in pharmaceutical preparations. On July 27, 1989 Smithkline Beecham Plc acquired Smithkline Beckman Corp for $16,082.37 million.

The Eli and Edythe L. Broad Institute of MIT and Harvard (/ˈbroʊd/), often referred to as the Broad Institute, is a biomedical and genomic research center located in Cambridge, Massachusetts, United States. The institute is independently governed and supported as a 501(c)(3) nonprofit research organization under the name Broad Institute Inc., and is partners with Massachusetts Institute of Technology, Harvard University, and the five Harvard teaching hospitals.

Moleculera Labs was founded by Drs. Craig Shimasaki and Madeleine Cunningham in 2011, to medically understand and clinically identify the underlying biological root of neurological, psychiatric, and behavioral disorders. Similar to the emergence of the immuno-oncology connection, epidemiological and research evidence demonstrates that a large portion of neuropsychiatric disorders are caused by an autoimmune dysfunction. The Company owns and operates a fully accredited clinical laboratory with its first revenue generating product—a blood panel called the Cunningham Panel™ that detects brain and nervous system targeted autoimmune antibodies in patients with neurologic, psychiatric, and behavioral disorders triggered by an infection. Patients are diagnosed with PANS, PANDAS, autism spectrum disorder, ADD/ADHD, bipolar disorder, anxiety disorder, Tourette’s, obsessive compulsive disorder (OCD), schizophrenia, or other neurologic and psychiatric syndromes, whereas the root may be a dysfunctional immune response. Symptoms include OCD, anxiety, depression, psychosis, motor or vocal tics, verbal and non-verbal communication difficulty, deteriorating social skills, eating disorders, academic regression, and rage. These patients are typically prescribed neuropsychiatric drugs, often resulting in little or no improvement. However, once a patient is correctly diagnosed through testing, treatment is redirected towards the immune system, neuroinflammation, and subclinical infections, resulting in remarkable recoveries, sometimes after decades of suffering. Moleculera is the sole clinical laboratory performing this panel covered by two U.S. patents. The Company has received and processed over 13,000 blood specimens ordered by over 1,700 physicians in over 50 countries, all prior to launching a sales force. The Company generated $1.1 MM in 2021 and is preparing to scale for revenue expansion with expectations of revenue ~$25 MM in 4-5 years. The company is now applying this technology to autoimmune cardiovascular disease and Long-COVID symptoms. The basic research that led to the identification of these antineuronal antibody targets was studied for over 20 years in the laboratory of Dr. Madeleine Cunningham at The University of Oklahoma Health Sciences Center, with subsequent collaboration from the Pediatric Branch of the National Institutes of Mental Health (NIMH). Scientific and clinical results have been published in multiple top-tier peer-reviewed journals. Certain infections that have been found to trigger these autoimmune antibodies include strep, Lyme, mycoplasma, Babesia, bartonella, coxsackie virus, and others. Medical journals have reported an autoimmune response to SARS-CoV-2 (COVID-19), with approximately one-third of patients experiencing some neurologic or psychiatric symptoms. The patented Cunningham Panel™ consists of five tests. Four which measure levels of autoantibodies directed against Dopamine D1 receptor, Dopamine D2L receptor, Lysoganglioside GM1, and Tubulin. A fifth test measures CaM Kinase II activation, a key enzyme involved in the production of neurotransmitters dopamine, epinephrine, and norepinephrine. Autoimmune antibodies that bind to these targets interfere with or block normal neurologic activity in the brain and nervous system. The laboratory results assist a physician in making a diagnosis and identifying the appropriate therapy. In addition to individual clinicians who order the panel, the Company has provided testing to over 80 medical institution customers. In a 2020 publication in the Journal of Neuroimmunology, the Cunningham Panel demonstrated an 88% sensitivity and 92% specificity with an accuracy of 90% correlating these autoantibody elevations and neuropsychiatric symptoms before and after treatment. The Cunningham Panel aids a clinician’s treatment decision by directing them to the underlying subclinical infections and neuroimmune dysfunction, rather than simply treating symptoms. Effective treatments typically include various anti-infectives, anti-inflammatory agents and immunomodulators. Moleculera' s Test Panel generates an average realized revenue of $900 through existing CPT codes and patient billing. The Company has generated over $10 million in cumulative revenue since opening. During the COVID-19 pandemic, revenues for 2021 were $1.1 million, all prior to adding a sales force. Approximately 10% of orders come from a growing international market, with the Company receiving orders from over 1,700 clinicians. Moleculera Labs has one of the largest IRB approved and clinically annotated serum specimen biobanks of over 13,000 specimens utilized for research and development of new products for autoimmune neuropsychiatric disorders. The Company has demonstrated its panel’s clinical utility in multiple neuropsychiatric disorders and have been able to predict treatment efficacy while working with pharmaceutical and research partners to assist in identifying novel drug targets. There is a clear unmet medical need and demand in this $23 billion dollar neuropsychiatric and behavioral disorder market. Moleculera recently in-licensed exclusive technology for multiple autoimmune antibody targets against the heart, which are implicated in a portion of multiple cardiovascular diseases such as heart failure, cardiomyopathy, atrial fibrillation, and myocarditis. With this technology along with proposed clinical studies and validation in process, the Company expects to develop and commercialize two additional panels. One panel will target various cardiovascular diseases (world-wide market of $4.9 trillion) infection-triggered autoimmunity, and another panel for diagnosing and treatment-monitoring of Long-COVID (estimated at $6.5 trillion). Our precision medicine business model is fashioned after Foundation Medicine and Genomic Health, whose precision medicine companies were acquired by Roche in 2018 for $5.3 billion, and Exact Sciences in 2019 for $2.8 billion, respectively. Moleculera Labs is led by Dr. Craig Shimasaki, a serial entrepreneur with over 35 years of biotechnology experience, who began his career at Genentech. He co-founded multiple companies, participated in taking several companies public into the U.S. and the Canadian stock exchange, led five products through the FDA diagnostic approval process, and has directed two CLIA labs, raising over $30 million for these companies. Dr. Madeleine Cunningham, Chief Scientific Officer, is an internationally recognized leader in infection-induced autoimmune neuropsychiatric disorders and is a tenured professor at the University of Oklahoma with over 40 years of research and over 130 authored publications in leading scientific and medical journals. Dr. James Appleman is VP of R&D and Clinical Development and has 30+ years’ experience in building successful diagnostic and therapeutic companies from inception through successful exits, including a $230M exit to Roche. Mr. Fred Hiller is CFO and brings 45+ years’ experience in corporate finance and accounting. He began his career at Touche Ross & Co. in 1962, serving as controller at Elgin National and Columbia Pictures, and CFO at Wilkinson Sword. He has been a financial consultant to numerous companies including two biotechnology companies and one that was publicly traded.