Pharnext is an advanced clinical-stage biopharmaceutical company founded in April 2007 by renowned scientists and entrepreneurs including Professor Daniel Cohen and collaborators, pioneers in modern genomics. The company develops new therapeutics for neurodegenerative diseases - orphan and common – where there are currently no cures and existing therapies available. Pharnext is the pioneer of a new paradigm for the discovery of medicinal drugs: PLEOTHERAPY™. The R&D approach protected by Pharnext systemizes new uses of approved drugs. It is based on network pharmacology utilizing complex and extensive genomic data to identify the thousands of molecules possibly involved in a disease. From this disease molecular network, Pharnext deduces synergistic combinations of drugs already approved but for unrelated indications. These novel therapeutics called PLEODRUG™ are then developed at new optimal doses and under new formulations. They offer several key advantages: efficacy, safety, and intellectual property including several composition of matter patents already granted. The proof of concept of the PLEOTHERAPY approach was obtained with PLEODRUG PXT3003 in Charcot-Marie-Tooth disease type 1A (CMT1A) through positive and consistent Phase 2 and Phase 3 results. PLEODRUG PXT864 generated encouraging Phase 2 data in Alzheimer’s disease. They also plan to develop the same agent in other orphan and common neurodegenerative diseases such as Parkinson’s disease and amyotrophic lateral sclerosis (ALS).

Altamira Therapeutics is dedicated to developing novel pharmaceutical therapies to protect hearing, silence tinnitus, and restore balance. Altamira Therapeutics is the leading pioneer in the emerging field of therapies for neurotologic disorders affecting the inner ear. They have two projects in advanced clinical development, Keyzilen® for the treatment of acute inner ear tinnitus and AM-111 for the treatment of acute inner ear hearing loss. In addition, they have AM-125 in early clinical development for the treatment of vertigo. They have additional projects under development and are further strengthening their pipeline through collaborations with leading academic institutions in this field.

Institut National de la Sant? et de la Recherche M?dicale provides medical services. The firm specializes in biomedical research and public health research. The company is headquartered in Paris, Cedex, France.

Merz Pharma GmbH & Co. KGaA is an innovative and international healthcare company with its own research and development department. It focuses on drugs for the treatment of illness in the fields of neurology and psychiatry. The company is bundling the activities of its subsidiaries Merz Pharmaceuticals, Merz Consumer Care, Merz Dental, and Merz Hygiene, with products ranging from prescription drugs and OTC products for health and wellness, materials for dentists and dental technicians to hygienic products for medical disinfection and cleaning.\nThe units of Merz Group Services, the fith Merz subsidiary, include Human Resources, Supply Chain/Purchasing, Information Technology (IT), Technical Operations and Finances/Controlling.

NoNO, Inc. operates as a biotherapeutics company. It engages in the research, development, and commercialization of pharmaceuticals for the treatment of common health disorders that include strokes, traumatic brain injuries, and pains. The company was founded by Michael Tymianski and Michael W. Salter in 2003 and is headquartered in Toronto, Canada.

Magpie Pharmaceuticals specialize in the research and development of first-in-class drugs. The company focuses on the structural modification and transformation of active natural product monomers in traditional Chinese medicines (TCM), as well as small molecular compounds currently in clinical use.

Develops and manufactures ophthalmic pharmaceutical products

GNT Pharma Co., Ltd. is a holding company, which develops new drugs for neurological and inflammatory diseases. Its pipeline include Neu2000, AAD-2004, and AAD-2004OAc. The company was founded by Byoung Joo Gwag, Seung Up Kim, Cheol Kim, Jai Sung Noh, Eui Ju Choi, Young Joon Oh, Cheon Gi Joo, and Sung Hwa Yoon on April 3, 1998 and is headquartered in Osan, South Korea.

LifeSplice Pharma LLC is an American private company. The firm develops drugs for neurological and non-neurological diseases.

Assistance Publique des Hôpitaux de Paris SA the company is headquartered in Paris, France.

Neurotech's founders have many years of experience in the development of innovative (cochlear) implants and implantable recording/stimulation electrodes. Neurotech SA was incorporated in 1996 to design, develop, manufacture and market active implantable medical devices for the treatment of debilitating disorders by neurostimulation.\nThe Company, in the heart of Europe near Brussels, has since acquired significant expertise in applied biomedical technology.

CV Therapeutics, Inc. operates as a research-based biopharmaceutical company. The Company researches and manufactures drugs for the treatment of cardiovascular disease and more specifically angina pectoris. CV Therapeutics serves the healthcare industry in the United States. CV Therapeutics developed Ranexa, a drug to treat chronic angina; and Lexiscan, an injection used as a stress agent in cardiovascular procedures. The company was acquired by Gilead Sciences, the maker of H.I.V. drugs Truvada, Viread, and Atriplia, for about $1.4 billion.

Mercaptor Discoveries, Inc. is a private company headquartered in Novato, CA. The firm engages in manufacturing drugs. It was founded in 2016 by Sara Isbell, Todd Zankel and Kim R. Tsuchimoto. Sara Isbell has been the CEO since the inception date.\nThe company says this about itself: Mercaptor Discoveries is a platform company with preclinical programs in neurology. Mercaptor's founding scientists discovered a natural chemical process occurring in the brain. This discovery brought about a platform to design injury-activated molecules called Captons™. Captons have reproducible POC and efficacy as neuroprotectants and have potential to prevent the progression of traumatic brain injury (TBI) and neurodegenerative diseases such as epilepsy, Alzheimer's disease, ALS, Parkinson's disease, MS and stroke. Mercaptor Discoveries was founded by a scientific team that has experience developing successful biotech companies, including Raptor Pharmaceuticals. Raptor was purchased by Horizon Pharma in 2016 for $860M USD.

RespireRx Pharmaceuticals Inc. is focused on developing drug candidates to treat very large respiration related markets that are unserved or poorly served. RespireRx is also developing drugs for niche respiratory markets where premium pricing is probable. All of the Company’s current efforts are involved with sleep apnea/hypopnea, respiratory depression and respiratory distress.

CHS Pharma (CHS) is a Biotechnology Development Company located in South Florida. CHS owns an Intellectual property portfolio for potential treatments related to Ischemic Stroke, Dry Macular Degeneration as well as other age related disorders such as Alzheimer’s disease. These technologies were developed by Dr. Jang-Yen Wu, Dr. Howard Prentice and their colleagues. Dr. Wu is a Senior Fellow and Distinguished Professor at Florida Atlantic University’s Charles E. Schmidt College of Medicine. Dr. Prentice is a Professor of Biomedical Science in the Charles E. Schmidt College of Medicine. Dr. Wu has published more than 300 papers in journals such as Science, Nature, PNAS, among others. He has made a great impact in biomedical sciences, particularly in basic and translational neuroscience, and is recognized as one of the most cited scientists in the world identified by Current Contents/ISI (2002). In translational neuroscience, Dr. Wu and his team have developed several mechanism-based treatments for neurodegenerative diseases including Parkinson’s disease, Ischemic Stroke, Alzheimer’s disease and Epilepsy. His inventions are quite novel and several patents have been awarded to him and his team. Dr. Prentice has over 70 publications in numerous journals including PNAS, EMBO Journal, Cell, Molecular Neurobiology, and Molecular and Cell Biology. Dr. Prentice’s principal research interests are in tissue hypoxia and ischemia and in molecular pathways of neuroprotection in stroke therapy.

G.D. Searle, LLC is a wholly owned trademark of Pfizer. It is currently used mainly as a distribution trademark for various pharmaceuticals that were developed by G. D. Searle & Company (often referred to as Searle). Prior to its 1985 merger with Monsanto, Searle was a company focusing on life sciences, specifically pharmaceuticals, agriculture, and animal health.

Advanced Neural Dynamics is a drug discovery company that provides neuroprotection against agents causing neurological impairment.

Curis is a drug development company that is committed to leveraging its innovative signaling pathway drug technologies to seek to create new targeted small molecule drug candidates for cancer. In expanding its drug development efforts in the field of cancer through its proprietary targeted cancer programs, Curis is building upon its previous experiences in targeting signaling pathways for the development of next generation targeted cancer therapies. For more information, visit Curis' website at www.curis.com.