Pharmaleads aims to provide patients suffering from severe chronic and acute pain with improved pain relief without the side effects associated with other classes of analgesics. Based on years of experience in the design of highly potent and specific inhibitors of enkephalinases, Pharmaleads has developed a new class of analgesics called DENKIs (Dual Enkephalinases inhibitors). These small molecules are able to provide patients with local and sustainable pain relief. Pharmaleads’ DENKIs are first-in-class drugs with a novel mechanism of action tackling pain by using endogenous enkephalins, natural peptides that specifically bind to pain-related opioid receptors to naturally modulate pain without the side effects observed with exogenous opioid drugs that also bind to other opioids receptors, not involved in pain control, triggering multiple side effects. Pharmaleads believes its products can change the lives of the many patients who are in need of improved treatment options for their chronic and/or acute pain, and could offer healthcare providers with an improved pain management option that helps address the opioid epidemic.

Senju Pharmaceutical Beijing Co. Ltd., part of Senju Pharmaceutical Co., Ltd., is a company headquartered in Beijing, China, that manufactures and distributes pharmaceuticals.

Farmalíder is a group of Spanish companies involved in the development, registration, licensing and production of generic pharmaceutical products – specialising in pain management, as evidenced by its market leading position in the ibuprofen and paracetamol markets in Spain – with a growing presence in other European markets.

Allergan, Inc. operated as a global healthcare company. It engaged in the development and commercialization of specialty pharmaceutical, medical device ,and over-the-counter products for the ophthalmic, neurological, medical aesthetics, medical dermatology, breast aesthetics, obesity intervention, urological, and other specialty markets. The company was founded by Gavin S. Herbert in 1950 and headquartered in Irvine, CA.

Guangxi Shengbaotang Pharmaceutical Industry Co., Ltd. (doing business as Sanpotel Pharmaceutical Co., Ltd.) is a Chinese private company located in Nanning that manufactures and sells genetic drugs and biological products.

Can-Fite BioPharma Ltd. is a biopharmaceutical company, which engages in the development of drugs for the treatment of cancer, liver and inflammatory diseases and erectile dysfunction. Its product pipeline include Piclidenoson, Namodenoson, and CF602. The company was founded by Pnina Fishman and Ilan Cohn on September 11, 1994 and is headquartered in Petach-Tikva, Israel.

Sylentis is a biotech company founded in 2006 and wholly owned by Pharma Mar S.A. (PHM:SM), with the mission of building a solid and sustainable business and becoming a leader of a new class of medicines based on RNA interference or RNAi. RNAi is a promising approach to silence targets involved in many diseases and represents a new drug mechanism of action. The Sylentis pipeline is aimed at indications with an elevated market potential, including ocular pathologies, inflammatory diseases and central nervous system diseases. Given the inherent complications of this technology regarding delivery of the active principle to the target tissue, our strategy is based on first selecting accessible therapeutic targets, which don not require systemic administration of the product. However, the development of formulations for RNAi technology to increase the therapeutic effect of these molecules is an area of great interest to the company

Beijing Plexiglass Products Factory, established on 1958-01-01, The business scope includes plexiglass and its products;plastic products;Technical Services,technical consulting;property management.(Enterprises independently choose operating projects according to law,Carry out business activities;Items subject to approval by law,Carry out business activities in accordance with the approved content after approval by relevant departments;Do not engage in the business activities of projects prohibited and restricted by the city's industrial policies.)

Rohto Pharmaceutical Co. Ltd. engages in the manufacture and sale of pharmaceutical products, cosmetics, and functional food items. Its products include eye drops, contact lens care, dermal medicines, skin care, internal medicines, cold remedies, test kits, and denture cleansers. Its operations are carried out through the following segments: Japan, America, Europe, Asia, and Others. The company was founded by Anmin Yamada on February 22, 1899 and is headquartered in Osaka, Japan.

Algomedix, Inc. is an American private company. The firm operates as a biotechnology company that develops novel therapeutics.

CXL Ophthalmics LLC is an American company located in Encinitas, CA. The firm develops a treatment for eyecare. Michael D. Webb is the current CEO of the firm.\nThe company says this about itself: CXLO is developing a minimally-invasive treatment for ectatic corneal disease that can bring early intervention to millions of patients globally. Our EpiSmart approach is a transformative cross-linking system designed to treat keratoconus without disrupting the epithelium, allowing for a rapid return to normal activities.

Cara Therapeutics is an emerging biotechnology company focused on developing novel therapeutics to treat human diseases associated with pain and inflammation. Cara possesses both near-term clinical development opportunities combined with proprietary approaches to developing first-in-class novel therapeutics. Cara's most advanced patented compound, CR845, is currently undergoing clinical testing for acute pain and pruritis. This best-in-class compound possesses unique analgesic and anti-inflammatory activities appropriate for multiple therapeutic applications. In addition, Cara aims to develop a future pipeline of first-in-class molecules at novel analgesic and anti-inflammatory targets using its proprietary drug screening technology.

Develops and manufactures ophthalmic pharmaceutical products

Korea OGK Co., Ltd. is a private company headquartered in the South Korea with a presence in China that engages in manufacturing of optical lenses and goggles. It was founded in 1981.

Qinghai Jiumei Tibetan Medicine Co., Ltd., established on 1999-04-05, The scope of business includes research and development of Chinese and Tibetan medicines,Chinese Tibetan Medicine Hard Capsules,Granules,Production and sales of pills and export of technology;Chinese and Tibetan herbal medicine purchase;Raw and auxiliary materials required for the production of the enterprise,Instrumentation,mechanical equipment,Spare parts and technology import business;feed processing and"Three to one make up"Processing business;Production and sales of Class I medical devices;Operating import and export commodities and agency business other than the state prohibits and restricts the company's operation.(The country has special regulations to operate with a license).****

Thyroscope wearable device analysis thyroid risk levels from body bio-signals and offers real-time updates without blood tests.

Shanxi Health Road Medical Equipment Co., Ltd., established on 2015-03-30, Business scope includes licensed projects:Production of Class II Medical Devices;Production of Class III Medical Devices;Class III medical device business;Production of disinfection products for the prevention and control of infectious diseases;Cosmetic production;Internet information service.(Items subject to approval by law,Business activities can only be carried out after approval by relevant departments,The specific business items are subject to the approval documents or licenses of relevant departments) General project:Sales of Class II Medical Devices;Production of Class I Medical Devices;Sales of Class I Medical Devices;Disinfectant sales(Free of Hazardous Chemicals);Manufacturing of daily chemical products;Daily necessities wholesale;Manufacture of technical textile products;Sales of industrial textile products;daily mask(non-medical)Production;daily mask(non-medical)Sales;Healthy food(prepackaged)Sales;Cosmetics Retail;Technical Services,technology development,technical consulting,Technology Exchange,technology transfer,Technology Promotion.(Except for projects subject to approval by law,Carry out business activities independently in accordance with the law with a business license)

Chongqing Wanshou Health Management Co., Ltd., established on 2019-08-02, Business scope includes general items:Health Management Consulting;Health massage service(The above scope does not include medical treatment and treatment);Pension Service;Undertake approved cultural and artistic exchange activities;marketing planning;Conference and Exhibition Services;Ecological agriculture project development;Sales:electronic product(Does not include electronic publications),daily necessities,vegetable,fruit,green plants(Does not contain tree seeds),food(After obtaining the relevant administrative license,Engage in business activities within the scope of the license),Ι class medical device,Health Supplies,primary agricultural products,teaching facility,teaching equipment;Engaged in technology development in the field of computer science and technology,technology transfer,technical consulting,Technical Services;Computer software and hardware development and sales.(Except for projects subject to approval by law,Carry out business activities independently in accordance with the law with a business license)

OKYO Pharma Ltd operates as a biopharmaceutical company, which engages in the development of therapeutics for inflammatory eye diseases and chronic pain. It targets to cure and prevent the following conditions: dry eye disease, non-infectious anterior uveitis, allergic conjunctivitis, and ocular pain. The company was founded on July 4, 2007 and is headquartered in London, the United Kingdom.