Engages in researching and development of new drugs and treatments

Institute For Research In Biomedicine is a Swiss private company located in Bellinzona that provides biomedicine research and development services.\nThe company says this about itself: Founded in 2000 in Bellinzona, the IRB is affiliated with the Università della Svizzera italiana, since 2010. IRB hosts 13 research groups studying defense mechanisms to fight infections, tumors and degenerative diseases. With more than 630 publications in main scientific journals, the IRB has gained international recognition as a center of excellence for immunology and cell biology. Molinari’s laboratory investigates the protein quality control processes determining whether a polypeptide should be secreted, retained in the ER, or selected for degradation. Particular emphasis is given to the study of select rare diseases such as a1-antitrypsin deficiency, LSDs and Charcot-Marie-Tooth 1B neuropathy.

sigma-tau is one of the most important Italian pharmaceutical groups, with a major presence also on the international stage. For more than half a century the company has been active in promoting the quality of life of man and his health. sigma-tau is present today in the most advanced research sectors, maintaining constant relations with scientific institutions with a world-wide reputation in the development of joint projects and in the implementation of original and innovative research programs. These results are the fruit of substantial, ongoing investment in research in the field of pharmaceutical innovation and stem not only from the efforts made to produce new products but also from the success of the company’s consolidated products. Bearing witness to sigma-tau’s achievements are not only the principles and values that inspire our efforts - innovation, dialogue and transparency, ethics, sustainability - but also the facts that have made sigma-tau a leading company in the research, manufacture and marketing of drugs.

4-Antibody AG develops human antibody drug-discovery platform for generating antibody therapeutics focused on immuno-oncology. Its technology platform Retrocyte Display is designed to generate therapeutic antibody drug candidates incorporating human antibody libraries expressed in mammalian B-lineage lymphocytes. The company also develops preclinical checkpoint antibody programs targeting GITR, OX40, CTLA-4, PD-1, TIM-3, and LAG-3. 4-Antibody AG was founded in 2002 and is based in Basel, Switzerland.

Agenus develops and commercializes immunotherapies and vaccines for cancer and infectious diseases. The company's treatment aims to stimulate the immune system to recognize and fight cancer cells. Its goal is to treat cancers with novel combinations utilizing its unique portfolio of checkpoint antibodies, tumor microenvironment modifiers, vaccines, and adjuvants. In addition to a broad portfolio, the company has an accomplished team of scientists, novel technology platforms, and fully-integrated end-to-end capabilities from discovery to GMP manufacturing. It was established in 1994 and is headquartered in Lexington, Massachusetts.

Aicuris Anti-Infective Cures AG is a German company located in Wuppertal that engages in research and development in natural sciences, engineering, agricultural sciences and medicines. It was founded in 2006 by Helga R��bsamen-Schaeff. Holger Zimmermann is currently the CEO of the firm.

Signal Pharmaceuticals Inc is pioneering the discovery and development of small molecule therapeutics which regulate the transcription factors involved in the progression of a number of inflammatory, viral and neurological diseases. The core technology for the company's research was discovered in the laboratories of three of its founders, and has been licensed from the University of California and the Salk Institute. (SB) It was located in San Diego, CA.

MedImmune develops medicines for unmet medical needs worldwide. As the global biologics research and development arm of AstraZeneca, MedImmune is pioneering innovative research and exploring novel pathways across key therapeutic including respiratory, inflammation, and autoimmunity; cardiovascular and metabolic disease; oncology; neuroscience; and infection and vaccines. Since its founding in 1988, MedImmune has remained committed to scientific innovation and medical progress, continually looking beyond standard expectations and pushing the boundaries of what is possible.

Fujirebio, Inc. engages in the manufacture, sale, import and export of clinical diagnostic reagents and assay instruments. It also provides diagnostic, clinical laboratory testing and related services. The company was founded on December 18, 1950 and is headquartered in Tokyo, Japan.

Evrys Bio LLC develops pharmaceutical products. It offers antiviral drug for respiratory infections, opportunistic infection, viral encephalitis, and liver infections. The company was founded by Thomas E. Shenk in 2012 and is headquartered in Doylestown, PA.

AiCuris is a clinical-stage biopharmaceutical company focused on resistance breaking antiviral and antibacterial therapeutics targeting Human Cytomegalovirus, Herpes simplex, HIV, Hepatitis B and C and multi-resistant bacteria. AiCuris‘ mission is the development of innovative drugs against severe and life-threatening infectious diseases with high medical need. AiCuris aims to be THE successful innovator for antiviral and antibacterial therapy.

Engages in providing general medical and surgical services and other hospital services

Merck Sharp & Dohme Corp. engages in the research, development, and distribution of vaccines, prescription drugs, and animal health products. The company is headquartered in Whitehouse Station, NJ.

Affymetrix, Inc. was an American company that manufactured DNA microarrays; it was based in Santa Clara, California, United States. The company was acquired by Thermo Fisher Scientific in March 2016. The company was founded by Stephen Fodor in 1992. It began as a unit in Affymax N.V. in 1991 by Fodor's group, which had in the late 1980s developed methods for fabricating DNA microarrays, called "GeneChip" according to the Affymetrix trademark, using semiconductor manufacturing techniques. The company's first product, an HIV genotyping GeneChip, was introduced in 1994 and the company went public in 1996. As a result of its pioneering work and the ensuing popularity of microarray products, Affymetrix derived significant benefit from its patent portfolio in this area.

Aviron Ltd engages in the research and development of specific antiviral agents against chronic Hepatitis C Virus (HCV) infection. The company has strategic alliances with CHEMRAR Hi-Tech Center, Chemical Diversity Research Institute, and DRUGS TECHNOLOGY, Ltd. Aviron Ltd was founded in 2010 and is based in Moscow, Russian Federation.

The Institute Pasteur is a private, non-profit foundation. Its mission is to help prevent and treat diseases, mainly those of infectious origin, through research, teaching, and public health initiatives.The Institut Pasteur is a research center of international renown ideally located in the very heart of Paris. Each year the institute hosts a multitude of scientific and medical conferences and meetings as well as events on a variety of themes.

Axxima Pharmaceuticals AG provided drug discovery and development services. It was a drug discovery company in the field of kinase inhibition. It specialized in kinase-based drug discovery aimed at treating certain forms of cancer. It had also focussed on on HIV, Hepatitis C, tuberculosis and one particular herpes virus infections. The company was headquartered in Munich, Germany.

Aviron LLC provides pharmaceutical research and development services. Its primary objective is research and development of innovative specific antiviral agents against chronic HCV infection. The company was founded in 2010 and is headquartered in Moscow, Russian Federation.