Spine Wave engages in developing and marketing medical devices for the treatment of spinal disorders. It focuses on commercializing technology platforms that offer surgical solutions for spine surgeons and their patients. Spine Wave offers expandable PEEK spacers and expandable interbody devices for posterior surgery; pivoting spacer systems; lateral spacer systems, XDL expandable devices, and lateral access systems for lateral stabilization; Leva PX, an expandable interbody device for the treatment of spinal disorders; GraftMag Graft Delivery System to deliver large amounts of bone graft; and fixation products such as spine systems for treating degeneration, deformity, tumor, and trauma of the thoracolumbar spine as well as adjacent level systems. Spine Wave also offers anterior cervical plate systems that provide stabilization as an adjunct to spinal fusion from C2-C7 through anterior screw fixation; and cervical spacer systems to treat degenerative disc disease from C2-T1. It offers its products through distributors. John Pafford and Mark LoGuidice founded Spine Wave on February 1, 2001. It has its headquarters in Shelton in Connecticut.

Spine View, Inc. develops and commercializes spine-related surgical and interventional products for spinal decompression and fusion applications. The company was founded by Daniel H. Kim, Lewis C. Pell, and Roy Chin on September 16, 2004 and is headquartered in Fremont, CA.

ArthroCare develops and manufactures surgical devices, instruments, and implants that strive to enhance surgical techniques as well as improve patient outcomes. Its devices improve many existing surgical procedures and enable new minimally invasive procedures. Many of ArthroCare's devices use its internationally patented Coblation (R) technology. This technology precisely dissolves target tissue and limits damage to surrounding healthy tissue. ArthroCare also develops surgical devices utilizing other patented technology including its OPUS (R) line of fixation products as well as re-usable surgical instruments. ArthroCare is leveraging these technologies in order to offer a comprehensive line of surgical devices to capitalize on a multi-billion dollar market opportunity across several surgical specialties, including its two core product areas consisting of Sports Medicine and Ear, Nose, and Throat as well as other areas such as spine, wound care, urology and gynecology.

DiscGenics, Inc. operates as a regenerative medicine company. It focuses on the devlopment of therapies that alleviate pain and restore function in patients with degenerative diseases of the spine. The company was founded in 2007 and is headquartered in Salt Lake City, UT.

Part of Medtronic Plc, Warsaw Orthopedic, Inc. is a company headquartered in the United States that operates orthopedic center.

Laserscope, Inc. manufactures medical laser systems for surgical and aesthetic applications. Its products are used to perform treatments including the removal of leg and facial veins, unwanted hair, pseudo-folliculitis and wrinkles. Laserscope was founded by Robert J. Pressley and Rodney C. Perkins in 1982 and is headquartered in San Jose, CA.

Barricaid develops a bone-anchored implant that reduces the incidence of reherniation and reoperation in patients with large annular defects. It is designed to prevent reherniation by physically blocking the annulus at the post-surgery defect. The anchor component is comprised of titanium alloy that is placed into either the caudal or cranial-adjacent vertebral body to secure the device in position.

TransCorp, Inc. developed and commercialized novel minimally invasive surgical instruments and implants for neurosurgical and orthopedic applications. The company was founded by Desmond O'Farrell, William K. Ilett, Scott Tuinstra, David Lowry and Roger Veldman in 2008 and was headquartered in Byron Center, MI.

Globus Medical, Inc. operates as a medical device company that develops and commercializes healthcare solutions. The firm engages in developing products that promote healing in patients with musculoskeletal disorders. It classifies products into Innovative Fusion and Disruptive Technology. It operates through the United States and International geographical segments. The company was founded by David C. Paul, David D. Davidar and Andrew Iott in March 2003 and is headquartered in Audubon, PA.

Spinal Restoration was formed to identify and develop new, early intervention, minimally invasive therapies for the treatment of chronic low back pain. The company’s first endeavor is the Biostat® System, a proprietary resorbable biologic compound and delivery system for the treatment of chronic disc pain. The new treatment specifically targets discogenic pain, which represents the single largest population of patients—an estimated four million adults—who suffer from chronic low back pain annually.

Anova, Inc. is a private company headquartered in Naperville, IL, that provides management consulting services.

Smith & Nephew Richards is a private company headquartered in Memphis, TN, involved in orthopedic, prosthetic, and surgical appliances and supplies.

Joimax specializes in the development and sales of systems for minimally invasive endoscopic spinal surgery. The company focuses on innovative technologies, systems, and methods for endoscopic minimally invasive spinal surgery. The surgical solutions guarantees a gentle treatment, always keeping interests of patients in mind. The complete surgical systems allow for a safe and cost-effective procedures. Joimax was founder on 2001 and is headquartered Irvine, California.

Howmedica Osteonics Corp., a subsidiary of Stryker Corp., is a company headquartered in Mahwah, NJ. The firm manufactures and supplies orthopaedic devices.

Seikagaku Corp. manufactures pharmaceuticals and medical devices with glycoconjugates; specifically, glycosaminoglycans (GAG) such as hyaluronic acid; as well as enzymes that act on GAG. It operates through the following segments: Pharmaceuticals and Limulus Amebocyte Lysate (LAL). The Pharmaceuticals segment develops and supplies intra-articular injections for improving joint functions, cross-linked hyaluronate hydrogel for knee osteoarthritis, opthalmic surgical aids, and surgical aids for endoscopic mucosal resection. The LAL segment manufactures and sells endotoxin-detecting reagents in Japan and overseas. The company was founded on June 2, 1947 and is headquartered in Tokyo, Japan.

TDM Corp. is a private company headquartered in Fletcher, NC. The firm manufactures machine tools.

Surgical Dynamics, Inc. provides medical devices and equipment. The company is headquartered in Norwalk, CT.

Komori Corp. KK is a Japanese company located in Gifu that manufactures offset printing machines and equipment. The firm was founded in 2000.