Santen Pharmaceutical Co., Ltd engages in the manufacture and sale of pharmaceutical products and medical devices. It operates through the following segments: Pharmaceuticals and Others. The Pharmaceuticals segment includes prescription ophthalmic drugs, anti-rheumatic pharmaceuticals, and over-the-counter products. The Others segment offers medical equipment and devices. The company was founded by Kenkichi Tagushi in 1890 and is headquartered in Osaka, Japan.

Allergan, Inc. operated as a global healthcare company. It engaged in the development and commercialization of specialty pharmaceutical, medical device ,and over-the-counter products for the ophthalmic, neurological, medical aesthetics, medical dermatology, breast aesthetics, obesity intervention, urological, and other specialty markets. The company was founded by Gavin S. Herbert in 1950 and headquartered in Irvine, CA.

NicOx is a biopharmaceutical company, engages in the development and commercialization of nitric oxide (NO)-donating drugs primarily for inflammation and cardio-metabolic diseases. The company's primary products candidates include Naproxcinod, a Phase III product candidate for the treatment of osteoarthritis; and NCX 6560, a NO-donating compound for the treatment of cardiovascular diseases, which is in phase I clinical trials. Its product portfolio comprise PF-03187207 for the treatment of glaucoma, TPI 1020 for the treatment of respiratory disorders, and NCX 1510 for allergic rhinitis, which are in Phase II clinical trials; and NO-donating antihypertensives, which is in phase I clinical trials for the treatment of hypertension. The company's product pipeline also include NCX 1047, which is in preclinical stage of development for treating a range of skin disorders, such as atopic dermatitis, psoriasis, and seborrheic dermatitis; and NO-donors for diabetic retinopathy, cardiometabolic, inflammation, and pain. It has research and co-development agreement with Orexo AB to identify and develop compounds for the treatment of airway diseases; license and development agreement with TOPIGEN Pharmaceuticals Inc. The company also has agreements with Grupo Ferrer Internacional SA for the research, development, and marketing of NO-donating anti-inflammatory drugs for the treatment of dermatological diseases; Pfizer Inc to identify nitric oxide-donating compounds for diabetic retinopathy; and Merck & Co., for the development of new antihypertensive drugs using NicOx' nitric oxide-donating technology. NicOx S.A. was founded in 1996 and is headquartered in Sophia Antipolis, France.

Wenzhou Eye Optometry Development Co., Ltd., established on 2013-01-05, Business scope includes hospital investment management;Business Management Consulting;Industrial Investment,Own Equipment Rental(Excluding financial leases),asset Management;Glasses frame,Development of lenses and low vision aids,Sales,technical consulting;Optometry professional consultation;Medical Technology Consulting;Medical Information Consultation(The above does not include medical services);Science and Technology Information Consulting;Glasses processing and repair;R&D of software technology,test,Consulting Services and Technology Transfer;care solution,other daily necessities,cosmetic,Sales of health products;clothing,furniture,lamps,Office Supplies,Wujinjiaodian,household appliances,Research and development of electronic products,Sales,technical consulting;Medical device management(see specific project<Medical device operating enterprise license>,Operating within the validity period of the above license).(Items subject to approval by law,Business activities can only be carried out after approval by relevant departments)

Part of Precipio, Inc., PGxHealth LLC is an American company located in New Haven, CT. The firm engages in clinical laboratory testing services.

Alcon, Inc. engages in the development, manufacture, and marketing of market surgical equipment and devices, pharmaceutical eye drops, and consumer vision care products to treat eye diseases and disorders. It operates through the following segments: Surgical and Vision Care. The Surgical segment offers implantable products, consumables and equipment for use in surgical procedures to address cataracts, vitreoretinal conditions, refractive errors, and glaucoma. The Vision Care segment comprises daily disposable, reusable and color-enhancing contact lenses, as well as portfolio of ocular health products, including over-the-counter products for dry eye, contact lens care, and ocular allergies, as well as ocular vitamins and redness relievers. The company was founded by Mr. Robert Alexander and Mr. William Conner on 1945 and is headquartered in Geneva, Switzerland.

Merck & Co., Inc. is a health care company, which engages in the provision of health solutions through its prescription medicines, vaccines, biologic therapies, animal health, and consumer care products. It operates through the following segments: Pharmaceutical, Animal Health, and Other. The Pharmaceutical segment includes human health pharmaceutical and vaccine products. The Animal Health segment discovers, develops, manufactures, and markets animal health products, such as pharmaceutical and vaccine products, for the prevention, treatment and control of disease in livestock, and companion animal species. The Other segment consists of sales for the non-reportable segments of healthcare services. The company was founded in 1891 and is headquartered in Kenilworth, NJ.

Santen specializes in the research, development, marketing, and sales of innovative eye care products and services that enable optimal sight. They help physicians address the complex clinical challenges in vision care with novel solutions for glaucoma, retinal diseases, and other eye conditions.

Allergan Sales LLC wholesales pharmaceutical products. It is a wholly-owned subsidiary of Allergan, Inc. The company is located in Englewood. CO

Kowa Co., Ltd. engages in trading of textiles, machinery, and construction materials. The company also manufactures and sells medicines, medical equipment, and energy saving products. It operates through the following business divisions: Pharmaceutical, Medical Device, Foods, General Trading, Lifestyle Business, and Hospitality. The company was founded on December 25, 1894 and is headquartered in Nagoya, Japan.

TheraTech, Inc. manufactures and distributes medical devices. The company was founded by Chick Sanford & Dinesh C. Patel in January, 1985 and is located in Hopkins, MN

Topcon, their core business is founded on the surveying instruments they have manufactured since their founding in 1932 and ophthalmic & medical equipment they introduced to the market following World War II. Since then, they have expanded their business domains through a combination of M&A and alliances, including construction machinery control technology since 1994, precision GPS receivers since 2000, precision agriculture since 2006, and mobile control technology since 2007. Today, the world is facing an increase in eye diseases due to global population aging, food shortages caused by global population increase, global infrastructure demands and a shortage of engineering personnel to meet that demand, and continued infrastructure deterioration. In the domains of healthcare, agriculture, and infrastructure, they embraces the slogan "Topcon for Human Life" as they work to expand their business by applying Topcon solutions towards resolving societal challenges.

Pfizer Inc. (NYSE: PFE, /ˈfaɪzər/) is an American multinational pharmaceutical corporation headquartered in New York City was founded in 1849, based in New York City and was listed on New York Stock Exchange. It is one of the world's largest pharmaceutical companies. It is listed on the New York Stock Exchange, and its shares have been a component of the Dow Jones Industrial Average since 2004. Pfizer ranked No. 57 on the 2018 Fortune 500 list of the largest United States corporations by total revenue.

Pharmacia Corp. developed, manufactured and marketed pharmaceutical products. Prescription pharmaceuticals included general therapeutics, ophthalmology and hospital products including oncology and diversified therapeutics. It also operated in consumer health care, animal health, diagnostics and contract manufacturing and bulk pharmaceutical chemicals. The customers of the group were pharmacies, hospitals, chain warehouses, governments, physicians, wholesalers and other distributors. It was headquartered in Peapack, NJ.

Novagali Pharma SA specializes in research, development and marketing of ophthalmic drugs. Their product pipeline includes products at various stages of development, which address diseases encountered at the three different segment levels of the eye which are surface, anterior and posterior segments. Some of these diseases are dry eye, allergy, glaucoma and retinopathies. Their formulations are based on their technology platforms Novasorb and Eyeject, which optimize bioavailability of drugs as well as safety and comfort for the patient. The company was founded on August 8, 2000 and is headquartered in Evry, France.

R-Tech Ueno Ltd. engages in the research and development, manufacture and sale of pharmaceutical products. It operates through the following business divisions: New Pharmaceutical Research and Development, Pharmaceutical Manufacture and Sale, and Pharmaceutical Development Support and Contract Manufacturing Services. The New Pharmaceutical Research and Development business provides development for unmet medical needs area, orphan drug area, and anti-aging area. The Pharmaceutical Manufacture and Sale business handles the manufacture and sale of Rescula Eye Drops for glaucoma and ocular hypertension. The Pharmaceutical Development Support and Contract Manufacturing Services business covers the manufacture and sale of AMITIZA capsules for chronic idiopathic constipation. It also accepts contract manufacturing of eye drops, liquid drugs and liquid-filled hard capsules. The company was founded by Ryuji Ueno and Sachiko Kuno in September 1989 and is headquartered in Tokyo, Japan.

Guangdong Dometic Smart Terminal Co., Ltd., established on 2020-08-03, Business scope includes mobile phone,dishwasher,vegetable washing machine,Disinfection machine,Air Purifier,Air disinfection equipment,Electronic equipment,communication data equipment,network security device,Terminal Equipment,Electronic Component,audio and video equipment,mobile phone accessories,Communication Products,electronic product,Smart Furniture and Components,digital product,smart toys,Production of wearable devices,to develop,Sales,Maintenance and technical consultation;Motherboard patch processing;Electronic components processing;Import and export of goods or technology(Except for the import and export of goods and technologies that are prohibited by the state or involve administrative approval);industrial design;graphic design;Structural Packaging Design;2D,3Danimation design;interface design;Development of Air Purification System;Technology development of intelligent manufacturing system for office space equipment,Technical Services,technical consulting,technology transfer;Mold and Plastic Products,e-cigarette,E-cigarette oil,electronic atomizing liquid,Plant extracts(Free of Hazardous Chemicals,precursor chemicals,Refined oil)technology development and sales;Domestic Trade;Mold and Plastic Products,Production and maintenance of electronic cigarettes.(The above items do not include pre-approval items for industrial and commercial registration)(Items subject to approval by law,Business activities can only be carried out after approval by relevant departments)

Part of Bausch Health Cos., Inc., Dr. Gerhard Mann Chem.-pharm. Fabrik GmbH is a German company located in Berlin that manufactures pharmaceutical products. William Woodfield and Eberhard Kühne are the current co-CEOs of the firm.

Pharmacia & Upjohn AB is a private company headquartered in Stockholm, Sweden. The firm manufactures pharmaceutical drugs.