The human microbiome is the aggregate of all microbiota that reside on or within human tissues and biofluids along with the corresponding anatomical sites in which they reside, including the skin, mammary glands, placenta, seminal fluid, uterus, ovarian follicles, lung, saliva, oral mucosa, conjunctiva, biliary tract, and gastrointestinal tract. Types of human microbiota include bacteria, archaea, fungi, protists and viruses. Though micro-animals can also live on the human body, they are typically excluded from this definition. In the context of genomics, the term human microbiome is sometimes used to refer to the collective genomes of resident microorganisms; however, the term human metagenome has the same meaning.
Quorum Innovations LLC
http://www.quoruminnovations.com
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Quorum Innovations LLC is an American private company located in Sarasota, FL, that provides biopharmaceutical services.\nThe company says this about itself: Dr. Nicholas Monsul, MD, CEO, and Dr. Eva Berkes, MD, Chief Science Officer, founded Quorum Innovations in 2011. Quorum Innovation's next generation probiotics �� Probiomics�� are being developed for application in skin care, food/beverages/ supplements, hygiene, and new drug candidates.
Probiotic
Microbiome
Medicine
Biopharmaceutical
Skin care
Hygiene
Prebiotic
Gastrointestinal agent
Solarea Bio, Inc.
http://www.solareabio.com
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Solarea Bio is a biotech company that develops microbial therapeutics aimed to treat indications derived from chronic inflammation to aid human health.
It specializes in the research and development of therapeutics that are derived from natural sources and are aimed to treat indications derived from chronic inflammation, enabling hospitals to provide medicinal drugs for improved quality of life. The company generates a large database of the complete genomic sequences of microbes derived from healthy foods. Using computational approaches, Solarea generates synergistic combinations of bacteria, fungi, and prebiotic fibers with powerful anti-inflammatory capabilities to address specific chronic conditions that afflict large numbers of people. These have been validated in-vitro and in-vivo in preclinical mouse models. Its first application aims to aid in the dietary management of the metabolic processes that cause osteopenia and osteoporosis in postmenopausal women. This provides a nature-based solution to improving women’s health and well-being.
The Cambridge, Massachusetts-based company was established in 2017 by Eric Schott, Gerardo Toledo, and Jillian DeWalt.
Microbiome
Inflammation
Biopharmaceutical
Novome Biotechnologies, Inc.
http://www.novomebio.com
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Novome Biotechnologies, Inc. is a biotechnology company focused on engineering defined activities into the human gut microbiota to treat chronic diseases. The Company has developed the first-ever platform for controlled colonization of the gut with engineered bacteria, enabling first-in-class living therapeutics: Genetically Engineered Microbial Medicines (GEMMs). Novome is utilizing its proprietary GEMMs platform in its lead preclinical program in hyperoxaluria, which is focused on the development of a therapeutic strain of bacteria that degrades oxalate to prevent the formation of kidney stones. Efforts are also directed to the expansion of its proprietary synthetic biology platform into additional indications.
Pharmacy and Therapeutics
Synthetic biology
Biotechnology
Metabolic engineering
Oxalate
Industrial biotechnology
Colonization
Third generation sequencing
Kidney stones
Microbiome
Plasmid
Microarray
Kidney
Microfluidics
Biopharmaceutical
Kaleido Biosciences, Inc.
Kaleido Biosciences is a clinical-stage healthcare company with a differentiated, chemistry-driven approach to leveraging the potential of the microbiome organ to treat disease and improve human health. The Company has built a human-centric proprietary product platform to enable the rapid and cost-efficient discovery and development of novel Microbiome Metabolic Therapies (MMT™). MMTs are designed to modulate the metabolic output and profile of the microbiome by driving the function and distribution of the organ’s existing microbes. Kaleido is advancing a broad pipeline of MMT candidates with the potential to address a variety of diseases and conditions with significant unmet patient needs.
Microbiome
Medicine
Biopharmaceutical
Biotechnology
Gastrointestinal agent
Pharmaceutics
Aptamer
Drug design
Cancer research
Toxicology
Clinical research
Biophysics
Biochemistry
Drug discovery
Exosome
Biomedicine
Enterome’s OncoMimic technology allows the overcoming of immune tolerance against cancer cells, with broad applicability against solid tumor via an off-the-shelf, easy to manufacture technology. Enterome’s potentially first-in-class small protein and peptide drug candidates modulate the immune system by closely mimicking the structure, effect or actions of Tumor Associated Antigens to induce a potent, endogenous CD8 T cell response. The company’s most advanced programs are in Phase 2 clinical trials in hard-to-treat tumors such as glioblastoma, adrenal malignancies and colorectal cancer.
Microbiome
Biology
Medicine
Biopharmaceutical
Bioactive molecules
Molecular interactions
Abnormality
Physiology
Human body
Immune system
Drug
Metagenomics
DNA sequencing
Genomics
Biotechnology
Biomedicine
Human microbiome
Companion diagnostic
Deep Longevity Ltd.
http://www.deeplongevity.com
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Deep Longevity Ltd. develops artificial intelligence systems to track the rate of aging at the molecular, cellular, tissue, organ, system and psychological levels. Its products include longevity cloud, recommendation engines, deep aging clocks and age metric reports. The company was founded in 2020 by Alex Zhavoronkov and is headquartered in San Diego, CA.
Biotechnology
Biomarkers of aging
Microbiome
Blood test
Johnson & Johnson Consumer, Inc.
http://www.johnsonsbaby.com
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Johnson & Johnson Consumer, Inc. manufactures health and skin care products. It offers wide variety of lotion, moisturizing cream, baby wash, shampoo and conditioner, baby powder and bath, hand and face wipes, soap, baby oil and cologne. The company was founded on March 8, 2016 and is headquartered in Skillman, NJ.
Skin care
Shower gel
Baby powder
Toothbrush
Lotion
Skin Care Product
Toothpaste
Oral hygiene
Aftershave
Hair spray
SOAP
Bandage
Hair conditioner
Precision medicine
Personalized medicine
Genome
Genomics
Xeno Biosciences, Inc.
http://www.xenobiosciences.com
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Xeno Biosciences operates as a biopharmaceutical company pioneering a novel class of therapeutics to address large unmet needs in metabolic diseases.
Lead program, XEN-101, is a first-in-class, oral formulation designed to shift the gut microbiome to the weight-loss associated state induced by Roux-en-Y Gastric Bypass (RYGB) surgery.
It was founded in 2015 and is headquartered in Somerville, Massachusetts.
Orgenesis, Inc.
http://www.orgenesis.com
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Orgenesis is a development stage company with a novel therapeutic approach in the treatment of diabetes by correcting malfunctioning organs with new functional tissues created from the patient’s own existing organs. Orgenesis employs a molecular and cellular approach directed at converting liver cells into functional insulin-producing cells as a treatment for diabetes. This new therapeutic approach is called Autologous Insulin Producing (AIP) cell transplantation.
Beta cell replacement is one of the most promising approaches for treatment of Insulin Dependent Diabetes Mellitus (IDDM). Currently, pancreas islet transplantation is the only approved cell replacement technology and it's the best available treatment for diabetics. However, it's impractical because of a shortage of donor tissue and rejection rate by the patient' immune system. Orgenesis believes that converting the diabetic patients own tissue to insulin producing cells will overcome the problem of donor shortage. Moreover, since the diabetic patient serves as his/her own donor, there is no risk of transplant rejection.
Orgenesis has manifested promising results in in-vitro and in-vivo studies using human liver tissues. Based on this significant discovery and these findings, Orgenesis has designed an efficient and clear work-plan to initiate clinical testing in the next few months allowing the company to launch phase I clinical trials following FDA guidelines followed by the launch of Phase II clinical trials within a year.
Pharmacy and Therapeutics
Cell
Insulin
Cell therapy
Diabetic patient
Biotechnology
Stem cell
Clinical trial
Therapeutic approach
Biomedicine
Stem-cell therapy
Donor tissue
Genomics
Beta cell
Rejection rate
Human liver
Transplant rejection
Diabetes mellitus
Pancreas
Cell potency
DSM Nutritional Products AG
DSM Nutritional Products AG, a subsidiary of Koninklijke DSM NV, is a company headquartered in Kaiseraugst, Switzerland. The firm manufactures vitamins, carotenoids, and other fine chemicals to the feed, food, pharmaceutical and personal care industries. Dimitri de Vreeze is currently the CEO of the company.
Vitamin
Carotenoid
Chemical engineering
Fine chemical
Feed additive
Tocopherol
Animal nutrition
Coenzyme Q10
Classical swine fever
Flavonoid
Hay
OMEGA-3 POLYUNSATURATED FATTY ACIDS
Monosodium glutamate
Silage
Zoonosis
Forage
Aquaculture
Starch
Nutraceutical
Enzyme
Freenome is a biotech company developing accurate, accessible, and non-invasive disease screening products for proactively treating cancer and other diseases at their most manageable stages.
The company is developing a simple blood test to detect early-stage cancer and make treatments more effective and provides a platform that helps design healthy conditions for an individual based on his/her cell-free genome. The company aims to reinvent disease management through systematized early detection and intervention.
Charles Roberts, Gabriel Otte, Riley Ennis, and Michael Otte launched the company in 2014 in South San Francisco, California.
Cancer detection
Medicine
Blood test
Machine learning
Illumina is an innovative technology and revolutionary assays aiming the analyze genetic variation and function.
These studies will help make the realization of personalized medicine possible. With such rapid advances in technology taking place, it is mission-critical to have solutions that are not only innovative, but flexible, scalable, and complete with industry-leading support and service. As a company that places a high value on collaborative interactions, rapid delivery of solutions, and prioritizing the needs of its customers, they strive to meet this challenge. Illumina's innovative, array-based solutions for DNA, RNA, and protein analysis serve as tools for disease research, drug development, and the development of molecular tests in the clinic.
David R. Walt, Satnam Alag, Larry Bock, and John Stuelpnagel co-founded Illumina in San Diego, California in 1998.
Molecular diagnostics
Genetic variation
Assay
RNA
Biology
Personalized medicine
DNA sequencing
Microbiology Test
Polymerase chain reaction
DNA
Microbiology
Immunoassay
Coronavirus
Drug development
Genomics
Genome
Bioinformatics
Molecular biology
Computational biology
Institut National de la Santé et de la Recherche Médicale
Institut National de la Sant? et de la Recherche M?dicale provides medical services. The firm specializes in biomedical research and public health research. The company is headquartered in Paris, Cedex, France.
Public health
Genomics
Antisense therapy
Epigenomics
Epigenetics
RNA interference
Messenger RNA
microRNA
Precision medicine
Genomic medicine
RNA
Genome
Cell signaling
AEON Medix, Inc.
http://www.aeonmedix.com
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KoBioLabs, Inc.
http://www.kobiolabs.com
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KoBioLabs, Inc. engages in the research and development of the microbiome. Its product is involved in the industries such as therapeutics, diagnostics, cosmetics, agriculture, and veterinary medicine. The company was founded by Ko Gwang-Pyo on August 11, 2014 and is headquartered in Seoul, South Korea.
Microbiome
Biopharmaceutical
Biotechnology
The Board of Trustees of the University of Illinois
http://www.bot.uillinois.edu
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The Board of Trustees of the University of Illinois, part of University of Illinois, is a company headquartered in Urbana, IL, that trusts Except Educational Religious.
Centre National De La Recherche Scientif
Ecole Nationale Veterinaire De Toulouse
École nationale vétérinaire de Toulouse (National Veterinary School of Toulouse, ENVT), is a veterinary school located in Toulouse, France. Established in 1825, it is also an institution of higher education and research and a teaching hospital.
Herbalife International, Inc.
http://www.herbalife.com
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Herbalife International, Inc. manufactures and distributes personal health care products. The firm provides weight management products to support weight loss and a healthy lifestyle. The company was founded by Mark Reynolds Hughes in February 1980 and is headquartered in Los Angeles, CA.
Food industry
Drug
Weight management
Weight loss
Vitamin
Sports nutrition
Amino acid
Meal replacement
Nutraceutical
Multivitamin
Functional food
Protein bar
Soy protein
Probiotic
Bodybuilding supplement
Calcium supplement
Bioactive compound
Royal jelly
Ginkgo biloba
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