Seikagaku Corp. manufactures pharmaceuticals and medical devices with glycoconjugates; specifically, glycosaminoglycans (GAG) such as hyaluronic acid; as well as enzymes that act on GAG. It operates through the following segments: Pharmaceuticals and Limulus Amebocyte Lysate (LAL). The Pharmaceuticals segment develops and supplies intra-articular injections for improving joint functions, cross-linked hyaluronate hydrogel for knee osteoarthritis, opthalmic surgical aids, and surgical aids for endoscopic mucosal resection. The LAL segment manufactures and sells endotoxin-detecting reagents in Japan and overseas. The company was founded on June 2, 1947 and is headquartered in Tokyo, Japan.

Barricaid develops a bone-anchored implant that reduces the incidence of reherniation and reoperation in patients with large annular defects. It is designed to prevent reherniation by physically blocking the annulus at the post-surgery defect. The anchor component is comprised of titanium alloy that is placed into either the caudal or cranial-adjacent vertebral body to secure the device in position.

Cervitech, Inc. is a medical device company engaged in the manufacturing, development, marketing & selling of artificial disc and cervical spine technologies. The company develops Porous Coated Motion artificial cervical disc system, which is a motion preserving total disc replacement device. It offers products to hospitals, clinics, surgery centers, physician offices, nursing homes, long-term care facilities, home and retail health care.

Synthesis BV engages in the design and production of synthetic water level regulation products. It offers penstocks, pipeline valves, accessories, channel slide gates, fish migration, float units, overflow pits, pivoted weirs, pipes, dirt grates, butterfly valve, and check valves. The company is headquartered in Emmeloord, the Netherlands.

Kyphon produces medical devices to treat and restore spinal anatomy using minimally invasive technology. It is engaged in developing surgical systems, apparatus and methods for mixing materials, instruments and methods for forming a cavity, and other products related to its industry. Kyphon operates as a subsidiary of Medtronic, Inc.It is based in Switzerland.

Zimmer Spine, Inc., a subsidiary of Zimmer Biomet Holdings, Inc., is an American company located in Minneapolis, MN. The firm designs, manufactures and distributes medical devices and surgical tools.

SpineOvations, a medical technology company, develops and commercializes products for the diagnosis and treatment of spinal disorders. It focuses on the development of novel, biocompatible injectables for the stabilization of spinal disc integrity; and for other orthopedic applications that include non-surgical connective tissue repair. Its technology platform consists of a novel non-surgical application for identifying and treating spinal discs that have tears or fissures in order to seal the defect and enhance structural integrity. SpineOvations offers DiscSeal, a percutaneous injection treatment for patients with internal disc derangement and suffering from chronic discogenic lower back pain. Its DiscSeal product is designed to be an early-stage treatment for those patients who have failed conservative care and who are not yet candidates for the invasive surgical treatment options of total disc replacement or spinal fusion. SpineOvations was founded in 2004. It has its headquarters in San Diego in California.

Spinal Restoration was formed to identify and develop new, early intervention, minimally invasive therapies for the treatment of chronic low back pain. The company’s first endeavor is the Biostat® System, a proprietary resorbable biologic compound and delivery system for the treatment of chronic disc pain. The new treatment specifically targets discogenic pain, which represents the single largest population of patients—an estimated four million adults—who suffer from chronic low back pain annually.

Spinal Stabilization Technologies is a medical device company. Spinal Stabilization Technologies, LLC is committed to the design, development, and manufacturing of spinal medical devices that meet or exceed the expectations of our patients, customers, and regulatory agencies; and to maintain and improve the effectiveness of our quality management system.

DePuy Synthes Products, Inc. develops and markets medical products. It offers distal volar Radius, which is designed to treat distal radius fractures, dorsal endoplate, an invasive dorsal nail plate that provides fixed angle support and intramedullary locked fixation with a duplicate and reproducible surgical procedure, spatial subchondral support plate, which is used to treat proximal humeral fractures and Small Bone Fixation System, a percutaneous locked intramedullary nail system for metacarpals and the phalanges. The company was founded on June 22, 2004 and is headquartered in Wilmington, DE.

Jiangsu Shengtang Medical Equipment Co., Ltd., established on 2015-09-10, Business scope includes licensed projects:Class III medical device business;Class III Medical Device Leasing(Items subject to approval by law,Business activities can only be carried out after approval by relevant departments,Specific business projects are subject to approval results) General project:Sales of Class I Medical Devices;Class I Medical Device Leasing;Sales of Class II Medical Devices;Class II Medical Device Leasing;Home Appliance Sales;General merchandise sales;Office Equipment Sales;Sales of mechanical and electrical equipment;Wholesale of computer software, hardware and auxiliary equipment;software development;Graphic design and production;marketing planning;Technical Services,technology development,technical consulting,Technology Exchange,technology transfer,Technology Promotion;Information Consulting Service(Not including licensing information consulting services);Health Consulting Services(Does not include medical services);Special Equipment Repair;rental service(Licensed rental services not included);business training(Does not include education and training,Vocational skills training and other licensed training)(Except for projects subject to approval by law,Carry out business activities independently in accordance with the law with a business license)

Spine Wave engages in developing and marketing medical devices for the treatment of spinal disorders. It focuses on commercializing technology platforms that offer surgical solutions for spine surgeons and their patients. Spine Wave offers expandable PEEK spacers and expandable interbody devices for posterior surgery; pivoting spacer systems; lateral spacer systems, XDL expandable devices, and lateral access systems for lateral stabilization; Leva PX, an expandable interbody device for the treatment of spinal disorders; GraftMag Graft Delivery System to deliver large amounts of bone graft; and fixation products such as spine systems for treating degeneration, deformity, tumor, and trauma of the thoracolumbar spine as well as adjacent level systems. Spine Wave also offers anterior cervical plate systems that provide stabilization as an adjunct to spinal fusion from C2-C7 through anterior screw fixation; and cervical spacer systems to treat degenerative disc disease from C2-T1. It offers its products through distributors. John Pafford and Mark LoGuidice founded Spine Wave on February 1, 2001. It has its headquarters in Shelton in Connecticut.

Shandong Guoshi Biotechnology Co., Ltd., established on 2019-10-30, Business scope includes technology development in the field of biotechnology,technical consulting,technology transfer;Ikind,IIkind,IIIclass of medical devices,Development of disinfection products,Sales;Toiletries,food,Healthy food,washing products,daily necessities,Processing of household appliances,Sales;Chemical materials(Hazardous Chemicals,Flammable and explosive products,Precursor Drugs Excluded),Chemical Products(Hazardous Chemicals,Flammable and explosive products,Precursor Drugs Excluded),Wholesale and retail of biological reagents.(Items subject to approval by law,Business activities can only be carried out after approval by relevant departments)

Chalmers Ventures is a Swedish firm that specializes in coaching, financing, and business development. They invest in companies which find themselves at the initial stage of their development. The company was founded in 2015.