Part of Medtronic Plc, Warsaw Orthopedic, Inc. is a company headquartered in the United States that operates orthopedic center.

SI-BONE, Inc. engages in the provision of implantable devices used in the surgical treatment of the sacropelvic anatomy. It offers a proprietary minimally invasive surgical implant system, called iFuse, used to fuse the sacroiliac joint to treat sacroiliac joint dysfunction that often causes severe lower back pain. The company was founded by Mark A. Reiley and Jeffrey W. Dunn on March 2008 and is headquartered in Santa Clara, CA.

Spine Wave engages in developing and marketing medical devices for the treatment of spinal disorders. It focuses on commercializing technology platforms that offer surgical solutions for spine surgeons and their patients. Spine Wave offers expandable PEEK spacers and expandable interbody devices for posterior surgery; pivoting spacer systems; lateral spacer systems, XDL expandable devices, and lateral access systems for lateral stabilization; Leva PX, an expandable interbody device for the treatment of spinal disorders; GraftMag Graft Delivery System to deliver large amounts of bone graft; and fixation products such as spine systems for treating degeneration, deformity, tumor, and trauma of the thoracolumbar spine as well as adjacent level systems. Spine Wave also offers anterior cervical plate systems that provide stabilization as an adjunct to spinal fusion from C2-C7 through anterior screw fixation; and cervical spacer systems to treat degenerative disc disease from C2-T1. It offers its products through distributors. John Pafford and Mark LoGuidice founded Spine Wave on February 1, 2001. It has its headquarters in Shelton in Connecticut.

Part of Medtronic Plc, SDGI Holdings, Inc. is an American company that manufactures medical equipment.

DePuy Synthes Products, Inc. develops and markets medical products. It offers distal volar Radius, which is designed to treat distal radius fractures, dorsal endoplate, an invasive dorsal nail plate that provides fixed angle support and intramedullary locked fixation with a duplicate and reproducible surgical procedure, spatial subchondral support plate, which is used to treat proximal humeral fractures and Small Bone Fixation System, a percutaneous locked intramedullary nail system for metacarpals and the phalanges. The company was founded on June 22, 2004 and is headquartered in Wilmington, DE.

Synthesis BV engages in the design and production of synthetic water level regulation products. It offers penstocks, pipeline valves, accessories, channel slide gates, fish migration, float units, overflow pits, pivoted weirs, pipes, dirt grates, butterfly valve, and check valves. The company is headquartered in Emmeloord, the Netherlands.

NuVasive is a medical devices company based in San Diego, California. The company primarily develops medical devices and procedures for minimally invasive spine surgery. NuVasive's products include software systems for surgical planning and monitoring, access instruments, and implantable hardware. Conditions that NuVasive products help treat are: degenerative disc disease, lumbar spinal stenosis, degenerative spondylolisthesis, cervical disc degeneration, early onset scoliosis, and limb length discrepancy.

Flexuspine operates as a spine company. It offers a spinal segment replacement to provide an alternative to lumbar fusion by re-establishing mobility to an affected segment of the lumbar spine. The company’s functional spinal unit is a comprehensive device composed of an interbody disc component and posterior dynamic resistance component to replace the natural kinematics of the motion segment. Flexuspine was founded on 2003 and is based in Pittsburgh, Pennsylvania.

Orthovita is a spine and orthopedic biosurgery company that manufactures and markets orthobiologic and biosurgery products. Its orthobiologics platform offers products for the fusion, regeneration, and fixation of human bones; and the biosurgery platform provides products for controlling intra-operative bleeding. Orthovita sells its products directly, as well as through non-stocking distributors and independent sales agents in the United States; and directly and through independent stocking distributors internationally. The company has strategic partnerships with Kensey Nash Corporation, Angiotech Pharmaceuticals, and Medafor. It was founded in 1992 and is based in Malvern, Pennsylvania.

Synthes USA LP used to manufacture medical devices. The company was founded by Hansjörg Wyss in 1974 and is headquartered in West Chester, PA.

Globus Medical, Inc. operates as a medical device company that develops and commercializes healthcare solutions. The firm engages in developing products that promote healing in patients with musculoskeletal disorders. It classifies products into Innovative Fusion and Disruptive Technology. It operates through the United States and International geographical segments. The company was founded by David C. Paul, David D. Davidar and Andrew Iott in March 2003 and is headquartered in Audubon, PA.

Renovis Surgical Technologies, Inc. develops, manufactures, and sells orthopedic medical implants to surgeons and hospitals. Its products include tapered cement less hip systems, acetabular cup systems, cross linked polyethylene products for hip bearings, cross linked polyethylene acetabular inserts with vitamin E, ceramic femoral heads, cruciate retaining knees, pedicle and cannulated screw systems, interbody systems, and external fixator systems. The company’s products are used in the areas of spine, orthopedics, adult joint reconstruction, and trauma surgery applications. Renovis Surgical Technologies, Inc. was founded in 2009 and is based in Redlands, California with engineering and manufacturing operations in Austin, Texas.

Founded in 1986 in China, Trauson, which manufactures spine devices and products for trauma surgeries, accounted for sales of about $60m in 2011. With the introduction of sophisticated manufacturing and processing equipment and measuring instruments, Trauson has also obtained the ISO13485-2003 certification of the China Quality Certification Center for Medical Devices. By the end of 2010, Trauson had received 100 registration certificates for its products. In addition, Trauson's main product has attained CE marks and US FDA 510(K), in 2007 and 2008 respectively. TRAUSON is the only trademark that has been awarded the well-known Chinese Brand in China's orthopedic industry.

Life Spine is focused on providing innovative solutions to address spinal pathology from the occiput to the sacrum. The company's comprehensive product portfolio that centers around fusion and minimally invasive surgeries is driven by patient and surgeon needs. Life Spine is dedicated to improving the quality of life for patients by increasing procedural efficiency and efficacy through innovative design, uncompromising quality standards and the most technologically advanced manufacturing platforms.

DePuy AcroMed, Inc. manufactures and supplies surgical and medical instruments. It designs, manufactures and supplies orthopaedic devices used in spinal surgery. It's products address disorders of the vertebral column, which include the cervical, thoracic and lumbar spine regions, to treat conditions related to degenerative diseases, deformities, trauma and sports-related injuries. The company is headquartered in Raynham, MA.

Corentec is a medical company that designs, manufactures, and markets a full line of orthopedic implants focusing on the hip, knee, and spine implant markets. Corentec is committed to Innovation, Product Excellence, and Total Customer Satisfaction. Its focus on these core values is fundamental to the company's mission to contribute to a healthy and active society. The company was founded in 2000 and is based in Seoul, South Korea with international operations in the US.

WINNOVA Co., Ltd. engages in the manufacture and sale of cosmetics and medical devices. Its products include original design manufacturing for skin, lotion, essence, power, sun block, body shower, shampoo, and others. The company was founded on May 18, 1995 and is headquartered in Pyeongtaek-si, South Korea.