Purdue Pharma L.P. is a privately held pharmaceutical company owned principally by descendants of Mortimer and Raymond Sackler. In 2007, it paid out one of the largest fines ever levied against a pharmaceutical firm for mislabeling its product OxyContin, and three executives were found guilty of criminal charges. Although the company shifted its focus to abuse-deterrent formulations, Purdue continued to market and sell opioids, and continued to be involved in lawsuits around the opioid epidemic in the United States. Purdue filed for Chapter 11 bankruptcy protection on September 15, 2019 in New York.

Part of Purdue Pharma LP, Rhodes Technologies, Inc. is a company headquartered in Coventry, RI. The firm engages in the manufacturing of pharmaceutical products.

ALZA Corp. is a pharmaceutical and medical systems company that develops, manufactures, and markets therapeutic systems. It provides oral, transdermal, implantable, and liposomal technologies. It is also focused on drug delivery systems with over 20 prescription pharmaceutical products. With over 10,000 employees, ALZA Corp. is a subsidiary of Johnson & Johnson. It was established in 1968 by Dr Alejandro Zaffaroni. It is based inVacaville, California.

Etypharm is a French private company, also operating in FR. The firm provides healthcare services.

Johnson Matthey is an international speciality chemicals company, founded almost 200 years ago in London. Technology leadership forms the basis of our strategy to deliver superior long term growth

Grünenthal GmbH engages in the research and development of pharmaceutical products. It specializes in pain, gout, and inflammation. The company was founded by Hermann Wirtz in 1946 and is headquartered in Aachen, Germany.

Napp Pharmaceutical Holdings Ltd. develops and provides medicines to patients. It offers prescription products for respiratory diseases such as asthma, inflammatory conditions, Crohn's disease, ulcerative colitis, ankylosing spondylitis, rheumatoid arthritis and psoriasis, as well as pain management, blood cancers, and cardiovascular conditions. The company was founded on December 19, 1997 and is headquartered in Cambridge, the United Kingdom.

Noramco was formed in 1979 to design, construct and manage a bulk active pharmaceutical ingredient plant in Wilmington, Delaware to support Ortho-McNeil Pharmaceutical's Tylenol® with codeine business. With the acquisition of Tasmanian Alkaloids and addition of the Athens, Georgia site in 1982, and continuous expansions over the past three decades at both US facilities, Noramco now contributes to billion dollar affiliate franchises, as well as to significant 3rd party generic and branded pharmaceutical products worldwide.

Zevra Therapeutics is a development-stage biopharmaceutical company focused on the discovery and development of new, safer therapies in the areas of pain, ADHD, and other CNS diseases. The company’s primary efforts include the development of safer, abuse-resistant opioid pain relievers. Its drug discovery and development platform is based on its proprietary Ligand Activated Therapy (LAT) approach. KemPharm uses its patent-applied technology to improve existing drugs and shorten the development timeline while still maintaining a strong intellectual property position within each therapeutic area.

Signature Therapeutics, Inc. (formerly PharmacoFore) is a privately-held biopharmaceutical company focused on creating novel medicines to improve upon the therapeutic utility of existing drugs, enhance patient care, and prevent the misuse, abuse, and overdose of prescription medications. They have developed a resilient business model for creating long-term value by pursuing a portfolio of carefully chosen programs where in drug activity is based upon known mechanisms-of-action and where human proof-of-concept can be achieved early in clinical trials. Their initial focus is on medicines for the central nervous system (CNS).

QRxPharma is an Australian-based, commercial-stage specialty pharmaceutical company focused on the development and commercialization of new pain management and abuse prevention products Based on a development strategy that focuses on enhancing the clinical utility of currently approved compounds as well as bringing new products to market, the company's product portfolio includes both late and early stage clinical drug candidates with the potential for reduced risk, abbreviated development paths, and improved patient outcomes. In Q4 2013, the Company plans to refile with the US Food and Drug Administration a New Drug Application for its lead product candidate, immediate release MOXDUO®, for the treatment of acute pain. QRxPharma has entered into strategic agreements with Actavis Inc., Paladin Labs Inc. and Aspen Group for the commercialisation of immediate release MOXDUO in the US, Canada, Australia (including New Zealand and Oceania) and South Africa. The Company's clinical pipeline includes an intravenous (IV) and controlled release (CR) formulation of MOXDUO. QRxPharma is also collaborating with Aesica Formulation Development Limited, for the worldwide promotion of QRxPharma's proprietary Stealth Beadlets™ abuse deterrence technology.

Part of Siegfried Holding AG, Penick Corp. is a company headquartered in Newark, NJ, that makes pharmaceutical ingredients. Siegfried Holding AG acquired Penick Corp. on May 18, 2005 for $30 million.

Mundipharma Laboratories is a pain management company that deals with immediate, controlled-release tablets, formulations, and analgesics.