The enterprise is a biotechnology R&D enterprise founded by returned overseas students in Zhangjiang Hi Tech Park, Shanghai in 2002. Main business:
1) Preparation, production and characterization of biomedical materials;
2) Evaluation of drug metabolism and interaction in vitro;
3) Evaluation of drug transport and interaction in vitro;
4) Bioartificial liver dialysis therapy;
5) Research and development of synergistic mechanism of metabolic/transport interaction of traditional Chinese medicine;
6) Individualized medication based on drug interactions.
Using in vitro biotechnology as a platform, we strictly follow the corresponding guiding principles of the drug administration department, relevant medical ethics and animal rights, fully implement quality monitoring, and provide in vitro drug ADMET evaluation services, products and corresponding services for the new drug innovation team with high quality and punctuality.
The following outsourcing services provided support the screening and optimization of new drugs in the early discovery stage, the design of preclinical studies of new drugs and clinical approval. Many of these projects have successfully passed the clinical approval of the Chinese drug regulatory authorities and the US FDA.
• In Vitro and Ex Vivo CYP450 Inhibition / Induction
• Metabolic stability / Metabolite Identification / Metabolite Pathway Identification
• Transporter Evaluation: Substrate and inhibitors
• Permeability / solubility / Cytotoxicity / Protein binding
The following in vitro biological materials and reagents provided reflect high quality, timely delivery, reasonable price and high service (pre-sales consultation and after-sales service)
• Cryopreserved primary hepatocytes/microsomes/S9: human (Mongolian/Caucasian) and experimental animals (mice, rats, guinea pigs, rabbits, dogs, monkeys, pigs, cattle, chickens)
• Recombinant drug metabolizing enzymes
• Induced rat liver S9 fraction for mutagenicity studies
• Drug transporters: ABC transporter capsule/SLC transporter cell line
• Reagents for drug metabolism and transport: substrate, product, inhibitor, inducer