Hinabiotech is a manufacturer of medicated and nutritional feed additives. The company is dedicated to solving animal intestinal health issues through the use of innovative biotechnology. To develop, produce, and sell microbial preparations, pre-digestions, and other products, the company employs modern biotechnology such as bioengineering, enzyme engineering, protein engineering, and fermentation engineering.

China State Institute of Pharmaceutical Industry is a Chinese company located in Shanghai and ultimately controlled by the Government of China. The firm regulates pharmaceutical companies.

Changsha Zhongke Jingbo Biotechnology Co., Ltd., established on 2013-08-05, The business scope includes feed processing;feed retail;Livestock and Fishery Feed Wholesale;feed,Biological product,Research and development of plant extracts;Natural science research and experimental development;Biotechnology Extension Services.(Items subject to approval by law,Business activities can only be carried out after approval by relevant departments,Do not engage in unauthorizedP2Ponline loan,Equity crowdfunding,internet insurance,Asset management and cross-border finance,Third party payment,virtual currency transaction,ICO,Internet financial services such as illegal foreign exchange)

Wuhu Tianming Biotechnology Co., Ltd., established on 2010-03-03, Business scope includes bioscience and technology research services;Biological Research Services;Biotechnology Extension Services;Bioengineering technology development,technical consulting,Technology Exchange,technology transfer,Technology Promotion,Technical Services;Biological reagent research and development(In addition to dangerous goods);biomaterials,biochemical reagents(In addition to dangerous goods),Laboratory Consumables and Experimental Instruments,medical instruments,Cosmetics and hygiene products,Health Supplies,Healthy food,Sales of disinfection supplies(Including internet sales).Import and export of goods or technology(Except for the import and export of goods and technologies that are prohibited by the state or involve administrative approval).(Items subject to approval by law,Business activities can only be carried out after approval by relevant departments)**

Guangzhou Jinan University Pharmaceutical Biotechnology Research and Development Center Co., Ltd., established on 1999-07-08, The scope of business includes food science and technology research services;drug development;Medical Research and Experimental Development;Biotechnology Development Services;Biotechnology Consulting,communication service;Biotechnology Transfer Services;Commodity wholesale trade(Except for licensed and approved products);Commodity retail trade(Except for licensed and approved products);laboratory testing(Those involving licensed projects need to obtain a license before they can engage in business operations);Biological Products Testing;Chemical product testing service;

Jiangsu Kangjun Biotechnology Co., Ltd., established on 2020-07-17, Business scope includes general items:Technical Services,technology development,technical consulting,Technology Exchange,technology transfer,Technology Promotion;Bio-feed R&D;Research and development of bio-based materials technology;Manufacturing of bio-based materials;Sales of bio-based materials(Except for projects subject to approval by law,Carry out business activities independently in accordance with the law with a business license)

Adenium Biotech is a Danish biopharmaceutical company spun out from Novozymes A/S in 2011. Adenium focuses on the development and commercialization of novel antibiotics for the treatment of multi drug resistant bacterial infections. Our focus is treatment of nosocomial infections, in particular complicated urinary tract infections and hospital or ventilator acquired pneumonia caused by multi drug resistant Gram-negative bacteria. Complicated urinary tract infections are caused by predominantly Gram-negative bacteria and in particular Escherichia coli. E. coli is also a frequent cause of many other common bacterial infections such as cholecystitis, bacteremia, cholangitis and traveler’s diarrhea, as well as other clinical infections such as neonatal meningitis and pneumonia. Most Infections caused by Escherichia coli are relative easy to cure, however, hospital adapted strains of Escherichia coli are often multi-resistant and are able to cause life threatening infections. Hospital acquired pneumonia (HAP) or ventilator acquired pnemonia (VAP) are also indications dominated by Gram-negative bacteria and in particular Pseudomonas aeruginosa and Klebsiella pneumoniae. P. aeruginosa has become an important cause of infection, especially in patients with compromised host defense mechanisms. It is the most common pathogen isolated from patients who have been hospitalized longer than 1 week and it is a frequent cause of nosocomial infections such as pneumonia, UTIs, and bacteremia. Infections caused by Klebsiella and Pseudomonas are complicated since many Pseudomonas aeruginosa and Klebsiella pneumoniae strains are multi drug resistant. Infections caused by Acinetobacter are rare and most strains found outside hospitals are sensitive to antibiotics. While Acinetobacter poses few risks to healthy individuals, a few species, particularly Acinetobacter baumannii, can cause serious infections – mainly in very ill trauma and hospitalized patients increasing the post trauma mortality as seen in wounded soldiers in the wars in Afghanistan and Iraq. The most common Acinetobacter infections include pneumonia, bacteraemia, wound infections, and urinary tract infections. ‘Hospital-adapted’ strains of Acinetobacter are often resistant to antibiotics and are increasingly difficult to treat. Adenium Biotech strives to find a novel treatment for multi-resistant Acinetobacter. Arenicin is a non haemolytic and non cytotoxic 21 amino acids antimicrobial peptide isolated from the lugworm. Arenicin has a strong and selective efficacy against Gram negative bacteria as well as a broad therapeutic window. Ten Arenicin variants were selected and subjected to a ranking program consisting of toxicology as well as in vitro and in vivo efficacy profiling. The three highest ranking Arenicin variants were selected in December 2013 for final lead optimization and selection of an Arenicin lead product candidate early in the fourth quarter 2013. Adenium Biotech is a semi-virtual biotech company with a small group of experts that supported by an international scientific advisory board focus on bringing the Arenicin program through clinical development to NDA filing.

Shenzhen Shengxima Biotechnology Co., Ltd., established on 2008-01-21, Business scope includes general business items:Technology development of biological polypeptide antibacterial peptide and biotechnology(Excluding laboratory and other restricted items);Sales of Feed and Feed Additives;Domestic Trade;Operating import and export business(None of the above is legal,Administrative regulations,The State Council decides to specify items that require pre-approval and prohibition).,The licensing program is:single feed(Candida utilis protein),premix feed,Production of mixed feed additives(Branch production and operation only).

Guilin Fengpeng Biotechnology Co., Ltd., established on 2021-08-19, Business scope includes general items:Manufacturing of bio-based materials;Sales of bio-based materials;Biochemical product technology research and development;Agricultural Science Research and Experimental Development;Technical Services,technology development,technical consulting,Technology Exchange,technology transfer,Technology Promotion;Feed Raw Material Sales;Feed Additive Sales;Food Additive Sales;Import and export(Except for projects subject to approval by law,Carry out business activities independently in accordance with the law with a business license)licensed items:feed production;Feed additive production;Food additive production(Items subject to approval by law,Business activities can only be carried out after approval by relevant departments,The specific business items are subject to the approval documents or licenses of relevant departments)

（1） Overview of Guangzhou Institute of Microbiology Guangzhou Institute of Microbiology is a technology development research institute directly under Guangzhou Science and Technology Innovation Commission, a national high-tech enterprise. It has three major centers: science and technology research and development center, technology service center, and Guanggong Micro Test Center. It is the operating agency of Guangzhou Biotechnology Park, mainly engaged in technical services and research in the fields of fermentation pilot test, bio agriculture, bio medicine, microbial fermentation, etc Product development. It has 8 provincial and municipal R&D institutions: South China Air Purification Product Testing Center, Guangdong Clean Room Engineering Testing Center, Guangzhou Biotechnology Park Product Testing Public Laboratory, Air Purification Product Testing Certification Center, Guangdong Fermented Microecological Product Engineering Technology Research Center, Guangdong Industrial Microbial Fermentation Technology Key Research Base, Guangdong Insect Virus Bioengineering Technology Research Center Guangzhou Key Laboratory of Microbiological Pharmacy; Four public science and technology service platforms have been built: Guangzhou Fermentation Engineering Technology Research Center, Biomedical Outsourcing Service Platform, Guangzhou Industrial Microbial Testing Center, and Guangdong Provincial Microbial Germplasm Resource Library, which are equipped with 18.2 million yuan of molecular biology, strain breeding, fermentation pilot test, separation and purification, quality analysis and other related equipment required for project research and development, It can provide "one-stop" scientific and technological achievements transformation services and innovation and entrepreneurship incubation services in the field of biotechnology. After more than 40 years of exploration, Guangzhou Institute of Microbiology has accumulated rich experience in the field of biotechnology. It has undertaken 270 scientific and technological projects above the urban level, more than 30 of which have won national, provincial and municipal awards for scientific and technological progress, including 6 provincial and ministerial awards since 2011; 307 papers have been published; A total of 21 patents have been granted, including 14 invention patents and 7 utility model patents, forming a patent pool for characteristic industries; The revenue from high-tech products (services) developed in recent three years totaled 114 million yuan. The Institute has 174 employees, including 141 scientific and technical personnel (including 4 professor level senior engineers, 11 senior engineers, 23 engineers; 38 skilled talents, involving pharmaceutical preparation workers, biopharmaceutical inspectors, fermenters, pharmaceutical commodity buyers and sellers, chemical inspection and other types of work, including 2 senior technicians, 7 technicians, 15 senior technicians), and 1 Guangzhou industrial development and innovation talent 5 key scientific and technological talents in the Development Zone and 9 new scientific and technological stars in Guangzhou; It has nearly 50 years of experience, foundation and ability in technical services, research and product development in the fields of biological agriculture, quality testing, fermentation pilot test, biomedicine, microbial fermentation, etc.

Beijing Yinghuier Biotechnology Co., Ltd., established on 2000-11-10, Business scope includes technology development,technology transfer,technical consulting,Technical Services,Technology Promotion;Technical Training;Sales of developed products,agricultural machinery,Computer hardware and software and peripheral equipment,feed,feed ingredients,Premix,Feed additives;Undertake computer network engineering;Information Consulting(No intermediary services);Conference Services;Import and export;Acting for the import and export of goods;Technology Import and Export;Compound processing single feed(Saccharomyces cerevisiae culture)(The feed production license is valid until2025year05moon31day);Compound processing mixed feed additive[limit:L-ascorbic acid(vitaminsC)+polyacrylic resinII;(L-ascorbic acid(vitaminsC)+Sodium carboxymethyl cellulose);(DL-Methionine+Calcium stearate);(L-Lysine hydrochloride+Calcium stearate);(Choline chloride+Calcium stearate);(Bacillus subtilis+Bacillus licheniformis+Enterococcus faecalis+Clostridium butyricum)](The feed additive production license is valid until2025year11moon08day);Compound processing additive premixed feed[limit:vitamin premix feed(Livestock and aquatic products,Ruminants);Micronutrient premixed feed(Livestock and aquatic products,Ruminants);Compound Premixed Feed(Livestock and aquatic products,Ruminants)](The feed production license is valid until2025year11moon08day);Compound processing feed additive(limit:L-ascorbic acid-2-Phosphate)(The feed additive production license is valid until2025year11moon08day)(Market entities independently choose business projects in accordance with the law,Carry out business activities;Items subject to approval by law,Carry out business activities in accordance with the approved content after approval by relevant departments;Do not engage in the business activities of projects prohibited and restricted by the industrial policies of the state and this city.)

China Animal Husbandry Industry Co., Ltd. engages in the research and development, production, sale, and service of animal health and nutrition products. Its products and services include animal health products, veterinary medicine, veterinary vaccine, daily products, food, pet products, bulk raw materials, and additive. The company was founded on December 25, 1998 and is headquartered in Beijing, China.

Shanghai Academy of Agricultural Science is a private company headquartered in Shanghai, China, that provides agricultural research services.