Polo-like kinases (Plks) are regulatory serine/threonin kinases of the cell cycle involved in mitotic entry, mitotic exit, spindle formation, cytokinesis, and meiosis. Only one Plk is found in the genomes of fruit flies (Polo), budding yeast (Cdc5) and fission yeast (Plo1). Vertebrates, however, have many Plk family members including Plk1 (Xenopus Plx1), Plk2/Snk (Xenopus Plx2), Plk3/Prk/FnK (Xenopus Plx3), Plk4/Sak and Plk5. Of the vertebrate Plk family members, the mammalian Plk1 has been most extensively studied. During mitosis and cytokinesis, Plks associate with several structures including the centrosome, kinetochores, and the central spindle.
Manufactures pharmaceuticals and diagnostic substances
Medicine
Botanical drug
Herb
Boehringer Ingelheim International GmbH
http://www.boehringer-ingelheim.com
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Boehringer Ingelheim International GmbH manufactures pharmaceutical prodcuts. It offers human and animal health products. The company was founded by Albert Boehringer in 1885 and is headquartered in Ingelheim, Germany.
Medicine
Bronchodilator
Inhaler
Metered-dose inhaler
Dry-powder inhaler
Nebulizer
Zoonosis
Medical ventilator
Oxygen concentrator
Cardiovascular agent
Pharmaceutical manufacturing
Animal welfare
Stroke
Enzyme
Cardiology
Kinase
Biosimilar
Drug discovery
Beta blocker
Active ingredient
Schering AG was a research-centered German multinational pharmaceutical company headquartered in Wedding, Berlin, which operated as an independent company from 1851 to 2006. In 2006 it was bought by Bayer AG and merged to form the Bayer subsidiary Bayer Schering Pharma AG, which was renamed Bayer HealthCare Pharmaceuticals in 2011. Schering was listed on the Frankfurt Stock Exchange and had 26,000 employees as of 2004.
Takeda Pharmaceutical Co., Ltd.
Takeda Pharmaceutical Company Ltd (武田薬品工業株式会社 Takeda Yakuhin Kōgyō Kabushiki-gaisha) is the largest pharmaceutical company in Asia and one of the top 20 largest pharmaceutical companies in the world by revenue (top 10 following merger with Shire). The company has over 30,000 employees worldwide and achieved 16.2 billion USD in revenue during the 2012 fiscal year. The company is focused on metabolic disorders, gastroenterology, neurology, inflammation, as well as oncology through its independent subsidiary, Takeda Oncology. Its headquarters is located in Chuo-ku, Osaka, and it has an office in Nihonbashi, Chuo, Tokyo. In January 2012, Fortune Magazine ranked the Takeda Oncology Company as one of the 100 best companies to work for in the United States.
Smithkline Beckman Corp, part of GSK Plc, is an American company located in Philadelphia, PA, involved in pharmaceutical preparations. On July 27, 1989 Smithkline Beecham Plc acquired Smithkline Beckman Corp for $16,082.37 million.
Elan Pharmaceuticals, LLC
Elan Pharmaceuticals LLC develops and manufactures pharmaceutical products. It specializes in treatment of neurological and autoimmune diseases. The firm's drugs are used in the treatment of for Alzheimer's, Parkinson's, and rheumatoid arthritis diseases. The company is headquartered in South San Francisco, CA.
Autoimmune disease
Medicine
Enzyme
Botulinum toxin
Proteasome
Lead compound
Lab-on-a-chip
High-throughput screening
Bioavailability
Antibody-drug conjugate
Monoclonal antibody
Contract research organization
Microfluidics
Oncology drugs
Drug discovery
Biomedicine
Biotechnology
Chroma Therapeutics Ltd.
http://www.chromatherapeutics.com
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Chroma Therapeutics is a privately-held biotechnology company focused on the discovery and development of novel small molecule drugs based upon chromatin biology and novel cell accumulation approaches. Chroma is the first company to systematically assemble intellectual property in chromatin biology and has established a strong network of academic collaborators. Chroma aims to build substantial shareholder value through the creation of a broad and innovative product pipeline aimed at the treatment of high-prevalence cancers and inflammatory disorders.
Information technology consulting
Software development
Small molecule
Chromatin
Medicine
Biomedicine
Biotechnology
Drug
Inflammation
Cell
Drug accumulation
RNA-Seq
Epigenomics
Epigenetics
Polymerase chain reaction
Bioinformatics
microRNA
Biomedical engineering
RNA
Biophysics
Rigel Pharmaceuticals, Inc.
Rigel Pharmaceuticals, Inc. operates as a clinical stage biotechnology company. It discovers and develops novel, targeted drugs in the therapeutic areas of immunology, oncology and immune oncology. The firm focuses on intracellular signalling pathways and related targets that are critical to disease mechanisms. The company's products include Tavalisse, Fostamatinib and R835. Rigel Pharmaceuticals was founded by Donald G. Payan, James M. Gower, Thomas A. Raffin, Garry P. Nolan and Ronald B. Garren on June 14, 1996 and is headquartered in South San Francisco, CA.
Pharmacy and Therapeutics
Fostamatinib
Biotechnology
Oncology
Intracellular signaling pathways
Clinical trial
Drug
Rituximab
Autoimmune disease
Therapeutic Area
Tocilizumab
Biomedicine
Cancer
Corticosteroid
Enzyme
Glomerulonephritis
Graft-versus-host disease
Spondyloarthropathy
Rheumatoid arthritis
Toll-like receptor
Amgen Inc. (formerly Applied Molecular Genetics Inc.) is an American multinational biopharmaceutical company headquartered in Thousand Oaks, California. In 2018, the company's largest selling product lines were Neulasta, an immunostimulator used to prevent infections in patients undergoing cancer chemotherapy and Enbrel, a tumor necrosis factor blocker used in the treatment of rheumatoid arthritis and other autoimmune diseases. Other products include Epogen, Aranesp, Sensipar/Mimpara, Nplate, Vectibix, Prolia and XGEVA.
Biopharmaceutical
TUMOR NECROSIS FACTOR BLOCKER
Medicine
Cancer chemotherapy
Molecular genetics
Rheumatoid arthritis
Autoimmune disease
Oncology drugs
Monoclonal antibody
Clinical trial
Immunotherapy
Bevacizumab
Cardiovascular agent
Adalimumab
Biosimilar
Genomics
Cancer immunotherapy
Antibody
Rituximab
Janssen Pharmaceutica NV
http://www.janssen.com/belgium
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Janssen Pharmaceutica is a pharmaceutical company headquartered in Beerse, Belgium and owned by Johnson & Johnson. It was founded in 1953 by Paul Janssen. In 1961, Janssen Pharmaceutica was purchased by New Jersey-based American corporation Johnson & Johnson, and became part of Johnson & Johnson Pharmaceutical Research and Development (J&J PRD), now renamed to Janssen Research and Development (JRD), which conducts research and development activities related to a wide range of human medical disorders, including mental illness, neurological disorders, anaesthesia and analgesia, gastrointestinal disorders, fungal infection, HIV/AIDS, allergies and cancer. Janssen and Ortho-McNeil Pharmaceutical have been placed in the Ortho-McNeil-Janssen group within Johnson & Johnson Company.
Product design
Neuroscience
Pharmacy and Therapeutics
Neurological disorder
Mental illness
Therapeutic Area
Medicine
Biomedicine
Biotechnology
Deck
Antifungal drug
Contract research organization
Companion diagnostic
Exosome
Infection drug
Clinical research
Immunotherapy
Biophysics
Antifungal
Bayer Pharma AG
http://www.bayerscheringpharma.de
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Bayer Schering Pharma AG is a research-centered pharmaceutical company that was formed by the merger of Schering with Bayer on 29 December 2006. The company was originally founded in 1851 by Ernst Christian Friedrich Schering. The company employs more than 26,000 people in 140 subsidiaries all over the world. The company's headquarters are in Berlin-Wedding, Germany and the forerunner company Schering's annual gross revenue was nearly € 5 billion. They retain the largest German manufacturing facility which is located in Bergkamen. The company focuses on the business areas of gynaecology and andrology, oncology, and also special therapeutics, diagnostical devices, and nuclear medicine. Schering's best-known product is their line of combined oral contraceptive pills. Through Bayer Healthcare AG, Bayer Schering Pharma is a full member of the European Federation of Pharmaceutical Industries and Associations.
Medicine
Nuclear medicine
Andrology
Pill
Oncology
Brachytherapy
Radiation therapy
Fidaxomicin
Ceftobiprole
Ceftaroline fosamil
Ceftolozane
Antibiotics
Radium-223 Dichloride
Degarelix
Enzalutamide
Triptorelin
Sipuleucel-T
Radiosurgery
Established in 1987, Korea United Pharm. Inc. has continued to develop as a pharmaceutical company with its slogan of "Korean owned multinational pharmaceutical company."
We have continuously launched new pharmaceutical drugs such as Cilostan CR Tab, Gastiin CR Tab, Clanza CR Tab and etc., through prestigious R&D investment, abundant know-hows and top expert researchers and have been placed as a strong competitor in the pharmaceutical drug development industry. they were named one of Asia's 200 most promising companies by the US economy magazine Forbes.
Pharmaceutical drug
Medicine
Boehringer Ingelheim Pharma GmbH
http://www.boehringer-ingelheim.de
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Proton-pump inhibitor
Antacid
Bevacizumab
Gastrointestinal agent
Besilesomab
ThioTEPA
Erlotinib
Cabazitaxel
Docetaxel
Immunotherapy
Oncology drugs
Protiva Biotherapeutics, Inc.
Protiva Biotherapeutics, Inc. develops pharmaceutical products for human diseases. The firm offers drugs for cancer, influenza (including H5N1), Ebola, inflammatory diseases and other chronic viral infections. The company was founded in September, 2000 and is headquartered in Seattle, WA.
Blueprint Medicines Corp.
http://www.blueprintmedicines.com
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Blueprint Medicines is driving the development of personalized, highly-selective cancer therapies that harness the growing understanding of the molecular blueprint of cancer. Using its powerful Insights-to-Validation Platform and proprietary chemical library, Blueprint Medicines is working to develop new therapeutic compounds and combination therapies that target the molecular aberrations that cause cancer and the emerging resistance mechanisms that make it increasingly difficult to treat.
Founded in 2011 by a proven team of scientists and entrepreneurs with world-renowned expertise in the development of targeted cancer therapies, cancer genomics, and rational drug development, Blueprint Medicines is poised to realize the promise of the cancer data revolution: truly personalized therapies that improve outcomes and shift cancer to a manageable condition.
Medicine
Cancer
Cancer therapy
Blueprint
Kinase
Exosome
Fibrodysplasia ossificans progressiva
Chemical library
Immunohistochemistry
Companion diagnostic
Drug discovery
Genomics
Drug development
Combination therapy
Biomedicine
Biotechnology
Imaging biomarker
Clinical trial
Orphan drug
Vertex Pharmaceuticals, Inc.
Vertex Pharmaceuticals, Inc. is a global biotechnology company, which engages in the business of discovering, developing, manufacturing, and commercializing small molecule drugs for patients with serious diseases. The firm focuses on development and commercializing therapies for the treatment of cystic fibrosis, infectious diseases including viral infections such as influenza and bacterial infections, autoimmune diseases such as rheumatoid arthritis, cancer, inflammatory bowel disease and neurological disorders including pain and multiple sclerosis. The company was founded by Joshua S. Boger in 1989 and is headquartered in Boston, MA.
Medicine
Cystic fibrosis
Small molecule
Drug
Huntington's disease
Genome
Ivacaftor
Inflammatory bowel disease
Genomics
Rheumatoid arthritis
Neurological disorder
Multiple sclerosis
Autoimmune disease
Biotechnology
CRISPR
Genome editing
Biopharmaceutical
Ventolín
Cell therapy
Concert Pharmaceuticals, Inc.
http://www.concertpharma.com
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Concert Pharmaceuticals is a clinical-stage biotechnology company dedicated to creating new medicines through a novel scientific approach utilizing the naturally-occurring element deuterium.
Concert applies its innovative precision deuterium chemistry platform to modify specific properties of validated drug molecules, yielding a rich pipeline of new chemical entities (NCEs). Concert leverages decades of pharmaceutical experience to create novel drug candidates with the potential for efficacy and safety, while greatly reducing R&D risk, time, and expense.
Deuterium
Medicine
Biotechnology
Clinical trial
Biomedicine
Drug molecule
New chemical entity
Nephropathy
Kidney disease
Interleukin
Peritoneal dialysis
Ciclosporin
Patiromer
Hemodialysis
Inhaler
Biomedical engineering
Cardiovascular agent
Drug
Takeda Chemical Industries Ltd.
Manufactures, marketes and imports, exports pharmaceutical drugs
Pharmaceutical drug
Botanical drug
Herb
University Health Network
University Health Network (UHN) is a healthcare and medical research organization in Toronto, Ontario, Canada. It is the largest such research organization in Canada and North America, ranking first in Canada for total research funding. It was named Canada's top research hospital by Research Infosource in 2015, 2016 and 2017. It was created in 1986 by the Government of Ontario through the merger of four major hospitals: Toronto General Hospital, Toronto Western Hospital, with the Princess Margaret Cancer Centre, and the Toronto Rehabilitation Institute merged in with The Toronto Hospital in 1999 and the name changed to the University Health Network. All four hospitals are affiliated with the Faculty of Medicine at the University of Toronto and serve as teaching hospitals for resident physicians, nurses, and other healthcare professions. UHN also operates The Michener Institute, an applied health sciences college that opened in 1958.
Ionis Pharmaceuticals, Inc.
http://www.ionispharm.com
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Ionis Pharmaceuticals, Inc. engages in the development and commercialization of human therapeutic drugs using antisense technology. It operates through the Ionis Core segment. The Ionis Core segment exploits a novel drug discovery platform to generate a pipeline of drugs. The company was founded by Stanley T. Crooke, David J. Ecker, Christopher K. Mirabelli, and Brett P. Monia in 1989 and is headquartered in Carlsbad, CA.
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