Tendyne Holdings, Inc. is a clinical stage medical device company focused on the development of minimally invasive therapies for the treatment of mitral regurgitation. Mitral regurgitation is a condition that afflicts hundreds of thousands of individuals worldwide every year. Formed in 2010, their first product concept is a transcatheter mitral valve replacement prosthesis for the treatment of mitral regurgitation. The intent is for the valve to be deployed and secured with no disruption to the native mitral annulus while preserving the sub-valvular apparatus. Placement of the valve is intended to be completed transapically in a simple procedure where the implanting physician is able to re-position, remove, and re-deploy their valve throughout the procedure.

Edwards Lifesciences Corp. engages in patient-focused medical innovations for heart disease and critical care monitoring. Its products are categorized into four main areas: Transcatheter Aortic Valve Replacement, Transcatheter Mitral and Tricuspid Therapies, Surgical Structural Heart, and Critical Care. It operates through the following geographical segments: United States, Europe, Japan, and Rest of World. The company was founded by Miles Lowell Edwards in 1958 and is headquartered in Irvine, CA.

Twelve, Inc. is a holding company, which engages in the operation as an investment fund for a medical device incubator. It specializes on funding and developing medical device inventions. The company focuses on medical and biotech ventures. The company was founded in 2009 and is headquartered in Redwood City, CA.

Cephea Valve Technologies, Inc. provides catheter delivered mitral valve regurgitation products/heart valves for the treatment of coronary artery disease in patients. It offers catheter based therapies, such as balloons and stents for aortic valves replacements. The company was incorporated in 2011 and is based in San Jose, California.

Caisson Interventional is a privately held clinical-stage medical device company focused on the design, development, and clinical evaluation of a novel percutaneous mitral valve replacement system.

4C Medical Technologies is a medical device company that develops minimally invasive therapies for structural heart disease. It preserves the native mitral valve and left ventricle, eliminating known issues associated with transcatheter mitral valve replacement technologies that rely on placement and fixation in the native mitral annulus and left ventricle. It was founded in 2015 and headquartered in Maple Grove, Minnesota.

Part of Abbott Laboratories, St. Jude Medical, Cardiology Division, Inc. is a company headquartered in St. Paul, MN. The firm develops and commercializes minimally invasive cardiovascular and neurovascular medical devices. It was founded by Paul R. Buckman. Lisa D. Earnhardt is currently the CEO of the company.

Medtronic, Inc. operates as a medical technology company. It offers implantable cardiac pacemakers, eternal defibrillators, inferior turbinate surgery products, and continuous glucose monitoring device. The company was founded by Earl E. Bakken and Palmer J. Hermundslie on April 29, 1949 and is headquartered in Minneapolis, MN.

Shanghai NewMed Medical Co., Ltd. engages in research, development, production of artificial heart valves and transcather implantation system. The company was founded by Yu QifengY in March 2015 and is headquartered in Shanghai, China.

Materialise GmbH, a subsidiary of Materialise NV, is a company headquartered in Gilching, Germany. The firm provides additive manufacturing software and 3D printing services. It was founded in 1990 by Wilfried Vancraen. Marcus Joppe and Johan Pauwels are the current co-CEOs of the company.

Medtronic Vascular designs and develops technologies for coronary, peripheral, and neurovascular indications. The company’s products include S7 Zipper MX Coronary Stent System, Clo-Sur PAD Nonwoven Hydrophilic Wound Dressing, Launcher Coronary Guide Catheter, and Stormer Over-the-Wire Balloon Dilatation Catheter. The company also offers Bridge Assurant Balloon-Expandable Stent Delivery System, GuardWire Plus Temporary Occlusion and Aspiration System, and S660 Coronary Stent. Medtronic Vascular was incorporated in 1991 and is based in Santa Rosa, California. As of January 29, 1999, Medtronic Vascular operates as a subsidiary of Medtronic.

Transmural Systems is a medical devices company with a platform of percutaneous structural heart therapies for cardiovascular diseases.

Part of Medtronic Plc, Medtronic Vascular Galway Unlimited Co. is a company headquartered in Dublin, Ireland. The firm manufactures and retails pharmaceutical products.

Medtronic 3F Therapeutics, Inc. develops, manufactures and markets cardiovascular devices. The company is headquartered in Minneapolis, MN.

3F Therapeutics develops, manufactures, and markets cardiovascular devices. It offers invasive and transapical aortic heart replacement technology, including enabling aortic heart valve, entrata aortic valve system, and endurance valve system to reduce surgical cross-clamp and cardio-pulmonary bypass time, utilization for congestive heart failure.