In biochemistry and pharmacology, receptors are chemical structures, composed of protein, that receive and transduce signals that may be integrated into biological systems. These signals are typically chemical messengers, which bind to a receptor, they cause some form of cellular/tissue response, e.g. a change in the electrical activity of a cell. There are three main ways the action of the receptor can be classified: relay of signal, amplification, or integration. Relaying sends the signal onward, amplification increases the effect of a single ligand, and integration allows the signal to be incorporated into another biochemical pathway. In this sense, a receptor is a protein-molecule that recognizes and responds to endogenous chemical signals. For example, an acetylcholine receptor recognizes and responds to its endogenous ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug targets, such as enzymes, transporters, and ion channels.
Immatics Biotechnologies GmbH
immatics is a biopharmaceutical company focused on the discovery of true targets for cancer immunotherapies with the development of the right T cell receptors.
The company's customized Adoptive Cell Therapies (ACTengine) and antibody-like TCR Bispecifics are the two main product classes in the pipeline (TCER). With a focus on particularly difficult-to-treat solid malignancies, each therapy modality has unique characteristics to create the desired therapeutic impact for patients at various disease stages and with various types of tumors.
immatics biotechnologies was established in 2000 by Hans Rammensee, Harpreet Singh, and Steffen Walter in Tübingen, Baden-Wurttemberg.
Medicine
Pharmacy and Therapeutics
Clinical trial
Biopharmaceutical
Immunotherapy
Cancer therapy
Cell therapy
Biotechnology
Oncology drugs
Cancer
Antibody
Cancer vaccine
Monoclonal antibody
Bevacizumab
Active immunotherapy
Kidney cancer
Oncology drug
Biomedicine
Colorectal cancer
F. Hoffmann-La Roche Ltd.
F. Hoffmann-La Roche Ltd. manufactures pharmaceutical products. It offers pharmaceutical drugs, pharmaceutical instruments, and diagnostics solutions. The company was founded by Fritz Hoffmann-La Roche on October 1, 1896 and is headquartered in Basel, Switzerland.
Medicine
Drug
Clinical trial
Biopharmaceutical
Genomics
Cancer research
Oncology drugs
Diagnostic test
Polymerase chain reaction
Neuroscience
Oncology
Cancer
Clinical chemistry
Genetic testing
Molecular diagnostics
Immunochemistry
Hematology
Tuberculosis
Urinalysis
Novartis AG is a holding company, which engages in the development, manufacture, and marketing of healthcare products. It operates through the following segments: Innovative Medicines, Sandoz, and Corporate. The Innovative Medicines segment researches, develops, manufactures, distributes and sells patented pharmaceuticals, and is composed of two business units: Novartis Oncology and Novartis Pharmaceuticals. The Sandoz segment develops, manufactures and markets finished dosage form medicines as well as intermediary products, including active pharmaceutical ingredients. The Corporate segment refers to group management and central services. The company was founded on February 29, 1996 and is headquartered in Basel, Switzerland.
Dosage form
Medicine
Clinical trial
Oncology
Oncology drugs
Cardiovascular agent
Monoclonal antibody
Immunotherapy
Inhaler
Adalimumab
Genomics
Bronchodilator
Rituximab
Biopharmaceutical
Dry-powder inhaler
Metered-dose inhaler
Optometry
Gastrointestinal agent
Bevacizumab
Bristol-Myers Squibb Company, through its subsidiaries, engages in the discovery, development, licensing, manufacturing, marketing, distribution, and sale of pharmaceuticals and nutritional products.
The company operates in two segments, Pharmaceuticals, and Nutritionals. The Nutritionals segment is operated through the company's subsidiary Mead Johnson Nutrition Company (Mead Johnson). The Pharmaceuticals segment is made up of the global pharmaceutical and international consumer medicines business.
Medicine
Oncology drugs
Clinical trial
Immunotherapy
Cardiovascular agent
Monoclonal antibody
Cancer immunotherapy
Bevacizumab
Biopharmaceutical
Insulin aspart
Drug discovery
Antiviral drug
Anticoagulant
Cardiology
Heparin
Drug development
Genomics
Cephalosporin
Stroke
Regeneron Pharmaceuticals, Inc.
http://www.regeneron.com
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Regeneron Pharmaceuticals is a biopharmaceutical company that discovers, develops, and commercializes pharmaceutical products for the treatment of serious medical conditions. The Company has therapeutic candidates in clinical trials for the potential treatment of cancer, eye diseases, and inflammatory diseases, and has preclinical programs in other diseases and disorders.
The company’s product portfolio includes EYLEA, an aflibercept injection; ARCALYST, a rilonacept Injection for subcutaneous use; ZALTRAP for metastatic colorectal cancer; trap fusion proteins; and fully human monoclonal antibodies. On March 26, 2012, it was announced that Sanofi and Regeneron are in development with a new cholesterol drug which will help reduce cholesterol up to 72%.
Regeneron Pharmaceuticals was founded in 1988 and is currently headquartered in New York, USA.
Monoclonal antibody
Clinical trial
Cholesterol
Medicine
Biopharmaceutical
Rilonacept
Aflibercept Injection
Colorectal cancer
Fusion protein
Biotechnology
Oncology drugs
Retina
Macular degeneration
Genomics
Drug
Immunotherapy
Antibody
Cardiovascular agent
Retinopathy
Genome
Eli Lilly engages in the discovery, development, manufacture, and sale of products in the pharmaceutical products business segment. The company manufactures and distributes products through owned or leased facilities in the United States, Puerto Rico, and 25 other countries. Its products are sold in approximately 135 countries. It also conducts research to find products to treat diseases in animals and to increase the efficiency of animal food production.
Medicine
Humalog Mix
Major depressive disorder
Breast cancer
Insulin
Clinical trial
Oncology drugs
Insulin pen
Idiopathic short stature
Insulin aspart
Generalized anxiety disorder
Bipolar I disorder
Peripheral neuropathic pain
Bulimia nervosa
Panic disorder
Growth hormone deficiency
Endocrinology
Fibromyalgia
Monoclonal antibody
Amgen Inc. (formerly Applied Molecular Genetics Inc.) is an American multinational biopharmaceutical company headquartered in Thousand Oaks, California. In 2018, the company's largest selling product lines were Neulasta, an immunostimulator used to prevent infections in patients undergoing cancer chemotherapy and Enbrel, a tumor necrosis factor blocker used in the treatment of rheumatoid arthritis and other autoimmune diseases. Other products include Epogen, Aranesp, Sensipar/Mimpara, Nplate, Vectibix, Prolia and XGEVA.
Biopharmaceutical
TUMOR NECROSIS FACTOR BLOCKER
Medicine
Cancer chemotherapy
Molecular genetics
Rheumatoid arthritis
Autoimmune disease
Oncology drugs
Monoclonal antibody
Clinical trial
Immunotherapy
Bevacizumab
Cardiovascular agent
Adalimumab
Biosimilar
Genomics
Cancer immunotherapy
Antibody
Rituximab
Juno Therapeutics, Inc.
http://junotherapeutics.com
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Juno is a clinical-stage company that brings together three of the world’s leading cancer centers – Fred Hutchinson Cancer Research Center, Memorial Sloan-Kettering Cancer Center and Seattle Children’s Research Institute – in unique partnership to advance a broad pipeline of breakthrough immunotherapies. With one of the largest ever Series A investments for a biotech startup, Juno will build on the foundation of novel immunotherapies to develop two distinct and complementary platforms – CARs and TCRs.
Immunotherapy
Clinical trial
Medicine
Pharmacy and Therapeutics
Cell therapy
Juno Therapeutics
Genomics
Oncology drugs
Cancer research
Monoclonal antibody
Cancer immunotherapy
Cancer
Biopharmaceutical
CRISPR
Biotechnology
Genome editing
Genome
Biomedicine
CD28
Pfizer Inc. (NYSE: PFE, /ˈfaɪzər/) is an American multinational pharmaceutical corporation headquartered in New York City was founded in 1849, based in New York City and was listed on New York Stock Exchange. It is one of the world's largest pharmaceutical companies. It is listed on the New York Stock Exchange, and its shares have been a component of the Dow Jones Industrial Average since 2004. Pfizer ranked No. 57 on the 2018 Fortune 500 list of the largest United States corporations by total revenue.
Janssen Pharmaceutica NV
http://www.janssen.com/belgium
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Janssen Pharmaceutica is a pharmaceutical company headquartered in Beerse, Belgium and owned by Johnson & Johnson. It was founded in 1953 by Paul Janssen. In 1961, Janssen Pharmaceutica was purchased by New Jersey-based American corporation Johnson & Johnson, and became part of Johnson & Johnson Pharmaceutical Research and Development (J&J PRD), now renamed to Janssen Research and Development (JRD), which conducts research and development activities related to a wide range of human medical disorders, including mental illness, neurological disorders, anaesthesia and analgesia, gastrointestinal disorders, fungal infection, HIV/AIDS, allergies and cancer. Janssen and Ortho-McNeil Pharmaceutical have been placed in the Ortho-McNeil-Janssen group within Johnson & Johnson Company.
Product design
Neuroscience
Pharmacy and Therapeutics
Neurological disorder
Mental illness
Therapeutic Area
Medicine
Biomedicine
Biotechnology
Deck
Antifungal drug
Contract research organization
Companion diagnostic
Exosome
Infection drug
Clinical research
Immunotherapy
Biophysics
Antifungal
Regents of the University of California
The University of California is the nation's best public university system, delivering top-notch research and innovation to California (and the world).
Pathology
Companion diagnostic
Genentech is a biotechnology company that discovers, develops, manufactures, and commercializes medicines to treat patients with serious or life-threatening medical conditions. It creates multiple products on the market and a development pipeline.
The company became a member of the Roche Group in 2009. As part of their merger agreement, Roche and Genentech combined their pharmaceutical operations in the United States. Genentech’s South San Francisco campus now serves as the headquarters for Roche pharmaceutical operations in the United States. Genentech’s Research and Early Development section operates as an independent center within Roche.
Genentech was founded in 1976 by [Robert Swanson](https://www.crunchbase.com/person/robert-a-swanson) and [Herbert Boyer](https://www.crunchbase.com/person/herbert-w-boyer). It is headquartered in South San Francisco, C.A.
Biotechnology
Biology
Medicine
Bevacizumab
Oncology drugs
Monoclonal antibody
Drug discovery
Rituximab
Immunotherapy
Biopharmaceutical
Cancer immunotherapy
Cisplatin
Paclitaxel
Pharmaceutical manufacturing
Genomics
Carboplatin
Cardiovascular agent
Biomedicine
Tocilizumab
Ixabepilone
AstraZeneca Pharmaceutical Co., Ltd.
http://www.astrazeneca.com.cn
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AstraZeneca has always believed in science, inspires infinite possibilities, and puts science at the top of all work. AstraZeneca's strategically important core treatment areas, and are committed to exploring pathogenic mechanisms, treatment methods, and innovative drugs, so that science can change people's lives and bring it to the medical industry Significant changes.
Merck Sharp & Dohme Corp.
Merck Sharp & Dohme Corp. engages in the research, development, and distribution of vaccines, prescription drugs, and animal health products. The company is headquartered in Whitehouse Station, NJ.
Prescription drug
Medicine
Stroke
Cardiology
Oncology drugs
Neurology
Cancer immunotherapy
Monoclonal antibody
Cardiovascular agent
Immunotherapy
Toxoid
Endothelin receptor antagonist
Prostacyclin
Contraceptive implant
Anticoagulant
Conjugate vaccine
Allergy drugs
Albiglutide
Adenoid cystic carcinoma
Mometasone/formoterol
Boehringer Ingelheim International GmbH
http://www.boehringer-ingelheim.com
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Boehringer Ingelheim International GmbH manufactures pharmaceutical prodcuts. It offers human and animal health products. The company was founded by Albert Boehringer in 1885 and is headquartered in Ingelheim, Germany.
Medicine
Bronchodilator
Inhaler
Metered-dose inhaler
Dry-powder inhaler
Nebulizer
Zoonosis
Medical ventilator
Oxygen concentrator
Cardiovascular agent
Pharmaceutical manufacturing
Animal welfare
Stroke
Enzyme
Cardiology
Kinase
Biosimilar
Drug discovery
Beta blocker
Active ingredient
Arena Pharmaceuticals, Inc.
http://www.arenapharm.com
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Arena Pharmaceuticals, Inc. is a biopharmaceutical company founded in 1997 and located in San Diego, California. The company has small molecule drugs in development for possible clinical utility in multiple therapeutic areas. The company’s most advanced investigational clinical programs are ralinepag (formerly APD811) in testing for pulmonary arterial hypertension (PAH), etrasimod (formerly APD334) in evaluation for inflammatory indications and APD371 for the treatment of pain associated with Crohn’s disease. In 2016 the company downsized and shifted its focus to developing new drugs currently being tested in clinical trials.
Clinical trial
Therapeutic Area
Stimulant
Drug
Medicine
Central nervous system
Biopharmaceutical
Small molecule
Prostacyclin
Cardiovascular agent
Endothelin receptor antagonist
Drug development
Drug discovery
Orphan drug
Obesity
Analgesic
Phentermine
Lorcaserin
Biotechnology
Chugai Pharmaceutical Co., Ltd.
http://www.chugai-pharm.co.jp
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Chugai Pharmaceutical Co., Ltd. engages in the research, development, manufacturing, sale, importation, and exportation of pharmaceuticals. Its operations are carried out through the Domestic and Overseas businesses. The Domestic Business covers the manufacturing, research, and development operations in Japan. The Overseas business comprises of sales and production in Europe, Taiwan and China. The company was founded by Juzo Ueno on March 10, 1925 and is headquartered in Tokyo, Japan.
Drug
Clinical trial
Medicine
Management system
Monoclonal antibody
Antibody
Viscosupplementation
Quality management system
Biopharmaceutical
Rituximab
Oncology drugs
Biotechnology
Antibody-drug conjugate
Cystic fibrosis
Attention deficit hyperactivity disorder
Biomedicine
Drug discovery
Pulmonary medicine
Drug development
Institut National de la Santé et de la Recherche Médicale
Institut National de la Sant? et de la Recherche M?dicale provides medical services. The firm specializes in biomedical research and public health research. The company is headquartered in Paris, Cedex, France.
Public health
Genomics
Antisense therapy
Epigenomics
Epigenetics
RNA interference
Messenger RNA
microRNA
Precision medicine
Genomic medicine
RNA
Genome
Cell signaling
The Board of Regents of The University of Texas System
The Board of Regents of The University of Texas System, a subsidiary of The University of Texas at Austin, is an American company located in Austin, TX. The firm oversees college activities.
Oncogene
Cancer immunotherapy
Oncology drugs
Manufactures pharmaceuticals
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