Part of Medtronic Plc, Warsaw Orthopedic, Inc. is a company headquartered in the United States that operates orthopedic center.

NuVasive is a medical devices company based in San Diego, California. The company primarily develops medical devices and procedures for minimally invasive spine surgery. NuVasive's products include software systems for surgical planning and monitoring, access instruments, and implantable hardware. Conditions that NuVasive products help treat are: degenerative disc disease, lumbar spinal stenosis, degenerative spondylolisthesis, cervical disc degeneration, early onset scoliosis, and limb length discrepancy.

Part of Medtronic Plc, SDGI Holdings, Inc. is an American company that manufactures medical equipment.

Globus Medical, Inc. operates as a medical device company that develops and commercializes healthcare solutions. The firm engages in developing products that promote healing in patients with musculoskeletal disorders. It classifies products into Innovative Fusion and Disruptive Technology. It operates through the United States and International geographical segments. The company was founded by David C. Paul, David D. Davidar and Andrew Iott in March 2003 and is headquartered in Audubon, PA.

DePuy Synthes Products, Inc. develops and markets medical products. It offers distal volar Radius, which is designed to treat distal radius fractures, dorsal endoplate, an invasive dorsal nail plate that provides fixed angle support and intramedullary locked fixation with a duplicate and reproducible surgical procedure, spatial subchondral support plate, which is used to treat proximal humeral fractures and Small Bone Fixation System, a percutaneous locked intramedullary nail system for metacarpals and the phalanges. The company was founded on June 22, 2004 and is headquartered in Wilmington, DE.

L&K BIOMED Co., Ltd. engages in the manufacture and sale of implants for vertebra. Its products include spinal fixation devices and spinal surgery products used in orthopedics and neurosurgery. The company was founded on December 22, 2008 and is headquartered in Yongin-si, South Korea.

Howmedica Osteonics Corp., a subsidiary of Stryker Corp., is a company headquartered in Mahwah, NJ. The firm manufactures and supplies orthopaedic devices.

Spine Wave engages in developing and marketing medical devices for the treatment of spinal disorders. It focuses on commercializing technology platforms that offer surgical solutions for spine surgeons and their patients. Spine Wave offers expandable PEEK spacers and expandable interbody devices for posterior surgery; pivoting spacer systems; lateral spacer systems, XDL expandable devices, and lateral access systems for lateral stabilization; Leva PX, an expandable interbody device for the treatment of spinal disorders; GraftMag Graft Delivery System to deliver large amounts of bone graft; and fixation products such as spine systems for treating degeneration, deformity, tumor, and trauma of the thoracolumbar spine as well as adjacent level systems. Spine Wave also offers anterior cervical plate systems that provide stabilization as an adjunct to spinal fusion from C2-C7 through anterior screw fixation; and cervical spacer systems to treat degenerative disc disease from C2-T1. It offers its products through distributors. John Pafford and Mark LoGuidice founded Spine Wave on February 1, 2001. It has its headquarters in Shelton in Connecticut.

X-spine Systems, Inc., a subsidiary of OrbiMed Advisors LLC, is an American company located in Miamisburg, OH. The firm manufactures medical devices for spinal surgery. It was founded by David L. Kirschman. X-spine Systems, Inc. was acquired by Bacterin International Holdings, Inc. on July 31, 2015 for $75.70 million.

Part of Stryker Corp., BioMimetic Therapeutics LLC is an American company located in Franklin, TN, that manufactures surgical and medical instruments.

DePuy AcroMed, Inc. manufactures and supplies surgical and medical instruments. It designs, manufactures and supplies orthopaedic devices used in spinal surgery. It's products address disorders of the vertebral column, which include the cervical, thoracic and lumbar spine regions, to treat conditions related to degenerative diseases, deformities, trauma and sports-related injuries. The company is headquartered in Raynham, MA.

Zimmer Spine, Inc., a subsidiary of Zimmer Biomet Holdings, Inc., is an American company located in Minneapolis, MN. The firm designs, manufactures and distributes medical devices and surgical tools.

Spinal Simplicity designs, develops, and sells percutaneously inserted interspinous inter-laminar fusion devices for the treatment of spinal problems to customers in the European Union. It offers Minuteman, an interspinous inter-laminar fusion device that provides relief from spinal ailments, such as spondylolisthesis, central and foraminal lumbar stenosis, and degenerative disc diseases. The company sells its products through distributors. Spinal Simplicity was founded in 2008 and is headquartered in Overland Park, Kansas.

Atlas Spine engages in the development and marketing of spinal instruments and implants. Its products include Verteview cervical plating systems; Rebar and Stature vertebral body replace systems; Back-PAK DS, a set of disc preparation instruments; and Apelo MIS Pedicle Screw System, a spinal implant system that is used in the treatment of spinal disorders, such as degenerative disc disease and deformity. Atlas Spine, Inc. was formerly known as Innovative Spinal Design and changed its name to Atlas Spine, Inc. in September 2005. The company was founded in 2001 and is based in Jupiter, Florida.

Spineology provides anatomy-conserving spine surgery technology solutions. It offers pedicular fixation products, such as Palisade, threshold, and fortress pedicular fixation; Biologics products, such as Essence viable amnion matrix, Blockade amniotic protective barrier, Incite DBM strips, and Incite cortical fibers; and Interbody products, such as the Duo systems, Elite expandable, Rampart one, and Rampart T interbody fusion products. Spineology also offers capture facet fixation, VIA spinous process fixation, Medius retractor system, SOAR retractor system, ProMap EMG nagivation systems, and OptiMesh graft containment. Stephan Kuslich founded it in 1996, with its headquarters in St. Paul in Minnesota.

Sanofi Genzyme is the specialty care global business unit of Sanofi, focused on rare diseases, multiple sclerosis, immunology, and oncology. They help people with debilitating and complex conditions that are often difficult to diagnose and treat. They are dedicated to discovering and advancing new therapies, providing hope to patients and their families around the world. Genzyme became part of Sanofi in 2011. While continuing to focus on rare diseases, they also established ourselves as a leader in the field of multiple sclerosis. In 2016, their focus expanded to include Sanofi’s programs in oncology and immunology. Their approach is shaped by a long history of developing highly specialized treatments and forging close relationships with physician and patient communities. Founded as Genzyme in Boston in 1981, they rapidly grew to become one of the world’s leading biotechnology companies, recognized for their pioneering development of treatments for rare genetic disorders and their innovative contributions to medical science and biomanufacturing.