Transient receptor potential channels (TRP channels) are a group of ion channels located mostly on the plasma membrane of numerous animal cell types. There are about 30 TRP channels that share some structural similarity to each other. These are grouped into two broad groups: Group 1 includes TRPC ( "C" for canonical), TRPV ("V" for vanilloid), TRPM ("M" for melastatin), TRPN ("N" for no mechanoreceptor potential C) , and TRPA ("A" for ankyrin). In group 2, there are TRPP ("P" for polycystic) and TRPML ("ML" for mucolipin). Many of these channels mediate a variety of sensations such as pain, temperature, different kinds of tastes, pressure, and vision. In the body, some TRP channels are thought to behave like microscopic thermometers and used in animals to sense hot or cold. Some TRP channels are activated by molecules found in spices like garlic (allicin), chili pepper (capsaicin), wasabi (allyl isothiocyanate); others are activated by menthol, camphor, peppermint, and cooling agents; yet others are activated by molecules found in cannabis (i.e., THC, CBD and CBN) or stevia. Some act as sensors of osmotic pressure, volume, stretch, and vibration.
Shanghai Leado Pharmatech Co Ltd
Shanghai Lidao Pharmaceutical Technology Co., Ltd., established on 2016-02-04, The scope of business includes engaging in medical technology,Technology development in the field of chemical science and technology,technical consulting,Technical Services,technology transfer,Engaged in the research and development of innovative drug technologies for the treatment of neurological diseases,Chemical raw materials and products(Removal of hazardous chemicals,Monitor Chemicals,firecrackers,civilian explosives,precursor chemicals),laboratory equipment,Sales of instrumentation.
[Items subject to approval by law,Business activities can only be carried out after approval by relevant departments]
The Queen's Medical Center
http://queensmedicalcenter.org
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The Queen's Medical Center provides health care services. It offers cancer care, behavioral health, orthopedics, physical therapy, women's health and surgery services. The company was founded by Queen Emma and King Kamehameha in 1859 and is headquartered in Honolulu, HI.
Eli Lilly engages in the discovery, development, manufacture, and sale of products in the pharmaceutical products business segment. The company manufactures and distributes products through owned or leased facilities in the United States, Puerto Rico, and 25 other countries. Its products are sold in approximately 135 countries. It also conducts research to find products to treat diseases in animals and to increase the efficiency of animal food production.
Medicine
Humalog Mix
Major depressive disorder
Breast cancer
Insulin
Clinical trial
Oncology drugs
Insulin pen
Idiopathic short stature
Insulin aspart
Generalized anxiety disorder
Bipolar I disorder
Peripheral neuropathic pain
Bulimia nervosa
Panic disorder
Growth hormone deficiency
Endocrinology
Fibromyalgia
Monoclonal antibody
Janssen Pharmaceutica NV
http://www.janssen.com/belgium
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Janssen Pharmaceutica is a pharmaceutical company headquartered in Beerse, Belgium and owned by Johnson & Johnson. It was founded in 1953 by Paul Janssen. In 1961, Janssen Pharmaceutica was purchased by New Jersey-based American corporation Johnson & Johnson, and became part of Johnson & Johnson Pharmaceutical Research and Development (J&J PRD), now renamed to Janssen Research and Development (JRD), which conducts research and development activities related to a wide range of human medical disorders, including mental illness, neurological disorders, anaesthesia and analgesia, gastrointestinal disorders, fungal infection, HIV/AIDS, allergies and cancer. Janssen and Ortho-McNeil Pharmaceutical have been placed in the Ortho-McNeil-Janssen group within Johnson & Johnson Company.
Product design
Neuroscience
Pharmacy and Therapeutics
Neurological disorder
Mental illness
Therapeutic Area
Medicine
Biomedicine
Biotechnology
Deck
Antifungal drug
Contract research organization
Companion diagnostic
Exosome
Infection drug
Clinical research
Immunotherapy
Biophysics
Antifungal
Hydra Biosciences, Inc.
http://www.hydrabiosciences.com
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Hydra Biosciences is a biopharmaceutical company based in Cambridge, Massachusetts, develops novel drugs to treat pain, inflammation, cardiovascular and other diseases using its expertise in novel ion channels. Hydra's proprietary high throughput screening platforms enable the company to identify and develop drug candidates that address significant unmet medical needs.
Hydra's ion channel drug discovery program is currently focused on channels implicated in pain, inflammation, and cardiovascular disease. Hydra's intellectual property portfolio, significant ion channel expertise, and flexible screening systems set it apart from other biopharmaceutical companies. Unlike classical sodium, calcium, or potassium voltage-gated channels Hydra's novel ion channels provide the potential to develop selective and safer ion channel drugs.
Hydra has raised significant financing from blue-chip investors since its inception. This prominent group of investors includes Abingworth Ventures, Advanced Technology Ventures, Polaris Ventures, Lilly Bio Ventures, New Enterprise Associates, BioVentures Investors, Biogen Idec, Boston Medical Investors, and MedImmune Ventures.
Ion channel
Biology
Medicine
Drug discovery
Inflammation
Biophysics
Biomedicine
Gabapentin
Biotechnology
Drug
Patiromer
Tanezumab
Pregabalin
Neuropathic pain
Light therapy
Opioid
Inhaler
Analgesic
Pharmaceutics
Amgen Inc. (formerly Applied Molecular Genetics Inc.) is an American multinational biopharmaceutical company headquartered in Thousand Oaks, California. In 2018, the company's largest selling product lines were Neulasta, an immunostimulator used to prevent infections in patients undergoing cancer chemotherapy and Enbrel, a tumor necrosis factor blocker used in the treatment of rheumatoid arthritis and other autoimmune diseases. Other products include Epogen, Aranesp, Sensipar/Mimpara, Nplate, Vectibix, Prolia and XGEVA.
Biopharmaceutical
TUMOR NECROSIS FACTOR BLOCKER
Medicine
Cancer chemotherapy
Molecular genetics
Rheumatoid arthritis
Autoimmune disease
Oncology drugs
Monoclonal antibody
Clinical trial
Immunotherapy
Bevacizumab
Cardiovascular agent
Adalimumab
Biosimilar
Genomics
Cancer immunotherapy
Antibody
Rituximab
Transposagen Biopharmaceuticals, Inc.
http://www.transposagenbio.com
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Transposagen Biopharmaceuticals is a privately held biotechnology company that is dedicated to providing unique animal models of human diseases for drug discovery and development. Transposagen is currently focusing on the $1.2 billion/year rodent model market. The rodent model market is experiencing double-digit annual growth due to the research and development needs of the pharmaceutical industry.
It was founded in 2003 and is headquartered in Lexington, Kentucky.
Animal model
Rodent
Drug discovery
Genome editing
CRISPR
Genomics
Genome
Genetic engineering
RNA
Biopharmaceutical
Biotechnology
Plasmid
Personalized medicine
Cell therapy
Messenger RNA
Molecular medicine
Clinical trial
Gene delivery
Transfection
Poseida Therapeutics, Inc.
Poseida Therapeutics is a clinical-stage biopharmaceutical company utilizing genome engineering capabilities to develop targeted therapeutics for patients with high unmet medical needs. The company develops a pipeline of autologous and allogeneic chimeric antigen receptor T cell or CAR-T, product candidates focusing on the treatment of hematological malignancies and solid tumors.
Poseida Therapeutics was founded in 2014 and is headquartered in San Diego, California.
Medical equipment
Pharmacy and Therapeutics
Chimeric antigen receptor
Genome engineering
T cell
Solid tumor
Genomics
Cell therapy
Biotechnology
CRISPR
Biopharmaceutical
RNA
Gene delivery
Viral vector
Genome editing
Genome
Oncology drugs
Plasmid
Genetic engineering
Transfection
Zhangzhou Pientzehuang Pharmaceutical Co., Ltd.
Zhangzhou Pien Tze Huang Pharmaceutical Co., Ltd. is a time-honored national high-tech enterprise. In December 1999, the Zhangzhou Pharmaceutical Factory established in 1956 was restructured into Pien Tze Huang Pharmaceutical. In June 2003, the company was listed on the Shanghai Stock Exchange. After two additional issues and one allotment, the company has now issued 603 million shares. Currently, the company has 34 holding subsidiaries, 8 joint -stock companies and 4 industry funds with more than 2,100 employees.
Pharmacy and Therapeutics
Drug
Medicine
Cubist Pharmaceuticals LLC
Cubist Pharmaceuticals, Inc. operates as a biopharmaceutical company focused on the research, development, and commercialization of pharmaceutical products that address unmet medical needs in the acute care environment. The company markets CUBICIN (daptomycin for injection), the first antibiotic in a new class of anti-infectives called lipopeptides in the United States. It began promoting MERREM I.V. (meropenem for injection) in the U.S. in July 2008. MERREM is an established spectrum antibiotic developed by AstraZeneca. The Cubist product pipeline includes ecallantide, a recombinant human protein in Phase 2 clinical trials; CONSERV-1 and CONSERV-2 for the reduction of blood loss during cardiac surgery; and two Phase 1 programs that address unmet medical needs, one in CDAD (Clostridium difficile-associated diarrhea) and the other in multi-drug resistant (MDR) Gram-negative infections. In addition, the company, in collaboration with Alnylam Pharmaceuticals, Inc., has a pre-IND and a Phase 2 program underway in novel treatments for respiratory syncytial virus infections using Alnylam's RNA-interference technology. Cubist was founded in 1992 and is headquartered in Lexington, Massachusetts.
Medicine
Meropenem
Biopharmaceutical
Tetracycline
Daptomycin
Ecallantide
Lipopeptide
Cephalosporin
Clostridium
Antibiotics
Cardiac surgery
Ceftaroline fosamil
Ceftolozane
Antifungal drug
Aminoglycoside
Antiviral drug
Penicillin
Hospital-acquired infection
Glenmark Pharmaceuticals SA
http://www.glenmarkpharma.com
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Glenmark Pharmaceuticals SA, part of Glenmark Pharmaceuticals Ltd., is a Swiss company located in Neuch��tel. The firm develops and Manufactures pharmaceuticals.
Bayer HealthCare AG
http://www.bayerhealthcare.com
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Bayer HealthCare AG provides healthcare, agriculture, plastics and chemical products. It is an independent company comprising five divisions: Animal Health, Consumer Care, Diabetes Care, Diagnostics and Pharmaceuticals. The company covers the fields of animal health, genetically produced medicines, over the counter products, diagnostic products and prescription drugs. The company is headquartered in Leverkusen, Germany.
Diabetes Therapy
Immunoprotein
Prescription drug
Immunofixation
Over-the-counter
Clinical chemistry
Nutrition
Medicine
Tumor marker
Therapeutic drug monitoring
Drug discovery
Drug test
Zoonosis
Cardiovascular agent
Biotechnology
Vaginal ring
Antifungal drug
Anticoagulant
Teijin Pharma Ltd.
http://www.teijin-pharma.co.jp
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Teijin Pharma Ltd. engages in the development, production, sales, and marketing of pharmaceuticals, and medical devices and supplies. The company operates in pharmaceutical and home healthcare businesses, focusing on bone and joint diseases, respiratory diseases, and cardiovascular and metabolic diseases. The company was founded in 2002 and is headquartered in Tokyo, Japan.
Medical equipment
Respiratory disease
Oxygen concentrator
Medicine
Bronchodilator
Medical ventilator
Inhaler
Positive airway pressure device
Nebulizer
Non-invasive ventilation
Metered-dose inhaler
Telemetry
Lesinurad
Colchicine
Teriparatide
Dry-powder inhaler
Corticosteroid
Spirometer
Resuscitator
Genentech is a biotechnology company that discovers, develops, manufactures, and commercializes medicines to treat patients with serious or life-threatening medical conditions. It creates multiple products on the market and a development pipeline.
The company became a member of the Roche Group in 2009. As part of their merger agreement, Roche and Genentech combined their pharmaceutical operations in the United States. Genentech’s South San Francisco campus now serves as the headquarters for Roche pharmaceutical operations in the United States. Genentech’s Research and Early Development section operates as an independent center within Roche.
Genentech was founded in 1976 by [Robert Swanson](https://www.crunchbase.com/person/robert-a-swanson) and [Herbert Boyer](https://www.crunchbase.com/person/herbert-w-boyer). It is headquartered in South San Francisco, C.A.
Biotechnology
Biology
Medicine
Bevacizumab
Oncology drugs
Monoclonal antibody
Drug discovery
Rituximab
Immunotherapy
Biopharmaceutical
Cancer immunotherapy
Cisplatin
Paclitaxel
Pharmaceutical manufacturing
Genomics
Carboplatin
Cardiovascular agent
Biomedicine
Tocilizumab
Ixabepilone
Glenmark Pharmaceuticals Ltd.
http://www.glenmarkpharma.com
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Glenmark was founded with a vision to emerge as a leading integrated research-based, global pharmaceutical company. Over the decades, we have established ourselves as a leading player in the discovery of new molecules both NCEs (New Chemical Entity) and NBEs (New Biological Entity). They have several molecules in various stages of pre-clinical and clinical development and are primarily focused in the areas of Oncology, Respiratory and Dermatology.
Medicine
New chemical entity
Dermatology
Oncology
Clinical trial
Inhaler
Metered-dose inhaler
Antifungal drug
Fluconazole
Dry-powder inhaler
Amphotericin B
Posaconazole
Biotechnology
Pharmaceutical manufacturing
Immunotherapy
Biomedicine
Allergy drugs
Itraconazole
Millennium Pharmaceuticals, Inc.
http://www.takedaoncology.com
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In 2008, Takeda Pharmaceutical Company Limited acquired Millennium Pharmaceuticals and the resulting company became exclusively focused on oncology. In 2014, Takeda Oncology was created to become the global headquarters for Takeda’s oncology specialty business unit, in Cambridge, Massachusetts, on the former Millennium Pharmaceuticals site. At Takeda Oncology they endeavor to deliver novel medicines to patients with cancer worldwide through our commitment to science, breakthrough innovation and passion for improving the lives of patients.
This singular focus drives our aspirations to discover, develop and deliver breakthrough oncology therapies. By concentrating the power of leading scientific minds and the vast resources of a global pharmaceutical company, they are finding innovative ways to improve the treatment of cancer.
They've built a portfolio of paradigm-changing therapies and a leading oncology pipeline. Though They've made great strides in our fight against cancer, they are determined to do more — to work harder and to reach higher. They continue to seek our aspirations with the same passion, agility and entrepreneurial spirit that has sustained our patient-centric culture and has made us the leaders in oncology that they are today.
Redpoint Bio Corp. is a development stage biotechnology company, which engages in the discovery and development of novel taste modulators for the food, beverage, and pharmaceutical industries. The company was founded by Robert F. Margolskee and Shawn M. Marcell in August 1995 and headquartered in Philadelphia, PA.
Shanghai Institutes for Biological Sciences CAS
Shanghai Institutes for Biological Sciences CAS is a private company headquartered in Shanghai, China, that operates as researching agency.
Biological sciences
Cardiovascular agent
Monoclonal antibody
Biopharmaceutical
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