Medtronic AF Luxembourg SARL, part of Medtronic Plc, is a Luxembourgish company that functions as an investment holding company.

SmartImplantSystems is a medical device company involved in the development of sensor-driven spine implants for the treatment of chronic back pain. In January 2014, Dr. Nazmi Peyman, a pain specialist, invented and patented the technology. In 2016 Dr. Peyman and Dr. Omid Souresrafil, an internal medicine doctor and medical device startup expert, founded the company to provide more advanced real solutions for long-term back pain sufferers. These are patients who have had little or no success with other pain management treatments. Once approved, we will offer patients relief to undertake simple daily tasks free of their discomfort. Patients can then live normal lives, free of the debilitating pain associated with spinal cord injuries and arthritis.

Boston Scientific Neuromodulation Corp. offers implantable pain management devices for neuromodulation. The company is headquartered in Marlborough, MA.

Autonomix Medical is a developer of a novel technology designed to bring clarity to minimally invasive renal denervation to treat heart disease. Its technology is used to develop minimally invasive neural monitoring and treatment devices for next-generation neuromodulation therapies that enable medical practitioners to accurately assess and treat peripheral and neural mediated disease. The company develops a proprietary microchip, hardware, and software which can be integrated into a catheter or other device to dramatically improve electrophysiologic signal fidelity and simplify data analysis. It was founded in 2014 and is headquartered in Excelsior, Minnesota.

Zensun (Shanghai) Sci & Tech Co., Ltd. is a biopharmaceutical company focusing on the development of innovative ‘first in class’ bio-therapeutic products for the treatment of serious and life-threatening unmet medical needs. They discover new medicines using novel disease specific targets and innovative technologies. The patented discoveries are then developed into therapies. With adherence to the tenet of “healing for life”, we hope to transform the lives of heart failure and cancer patients by providing them with drugs that treat their disease and not the symptoms. Zensun’s current pipeline covers cardiovascular disease treatment, anti-cancer drugs, and treatments for energy metabolism disorders.

Medtronic, Inc. operates as a medical technology company. It offers implantable cardiac pacemakers, eternal defibrillators, inferior turbinate surgery products, and continuous glucose monitoring device. The company was founded by Earl E. Bakken and Palmer J. Hermundslie on April 29, 1949 and is headquartered in Minneapolis, MN.

Metavention develops new treatment that is intended to permanently disrupt the overactive nerves that cause high blood pressure and other metabolic diseases. They offer a renal denervation procedure that delivers radio frequency energy to targeted overactive sympathetic nerves using their IRF denervation system.

Tesla Medical is a designer and manufacturer of neuromodulation-based medical devices for the non-invasive treatment of chronic diseases. Tesla Medical's device uses neuro-resonance to stimulate the bladder nerve receptors that cause hyperactivity and urinary leakage, allowing OAB patients to improve their quality of life by utilizing new perspectives and approaches.

Sorin CRM SAS designs and manufactures implantable pacemakers and defibrillators. It offers ICDs, leads, holter equipment, and electrophysiology catheters. The company was founded on July 25, 1977 and is headquartered in Clamart, France.

Rune Labs is a software and data platform for neuromodulation and brain therapies of the future. The platform's software-as-a-service platform works with existing and emerging neuromodulation systems to manage complex therapies and get the most value out of available data. Their cloud-based software platform provides these therapy developers the performance, scalability, and availability they need to run complex therapy algorithms across many patients, deliver precision medicine, and identify likely responders for clinical trials. Rune Labs was founded in 2018 and is headquartered in San Francisco, California.

Cardionomic treats reduced cardiac output – ADHF’s root cause – by neuromodulating the terminal branches of the cardiac plexus to benignly increase contractility. Cardionomic’s acute, non-systemic therapy will improve cardiac output, renal blood flow, urine production, and pharmacological tolerance. Concurrently the therapy also achieves the associated decreases in plasma norepinephrine (NE) and B-type natriuretic peptide (BNP), which are objective biomarkers of chronic heart failure.

Targacept, Inc. is a biopharmaceutical company, which is engaged in the design, discovery and development of a new class of drugs to treat multiple diseases and disorders of the nervous system by selectively targeting Neuronal Nicotinic Receptors, or NNRs. NNRs are found on nerve cells throughout the human nervous system and serve as key regulators of nervous system activity. Targacept was founded by J. Donald deBethizy, Merouane Bencherif, William S. Caldwell and Patrick M. Lippiello on March 7, 1997 and is headquartered in Winston-Salem, NC.

Tulavi Therapeutics is a biotechnology company that is dedicated to developing new therapies to treat neurally mediated diseases. The company's solution is dedicated to developing therapies that directly target the nerves to prevent and/or treat aberrant neural reflex arcs in the peripheral and visceral disease that can be administered through surgical and interventional approaches, enabling physicians to treat such diseases in a better way. The company was founded in 2018 and is headquartered in Mountain View, California.

Onward Medical BV operates as a medical technology company. The company creates therapies to restore movement, independence, and health in people with spinal cord injury. It's technology platforms are based on ARC Therapy targeted, programmed electrical stimulation of the spinal cord designed to restore movement independence, and health in people with SCI. The company was founded in 2014 and is headquartered in Eindhoven, the Netherlands.

NeuroPace designs develops, manufactures, and markets implantable devices for the treatment of neurological disorders. It offers a responsive Neurostimulator system (RNS) for the treatment of medically refractory partial epilepsy. The company's RNS system consists of implantable components, including RNS neurostimulator that delivers a short train of electrical pulses to the brain, and depth leads and cortical strip leads; and external products, such as the programmer, a laptop computer with proprietary software that has a wand and telemetry interface enabling communication with an implanted RNS neurostimulator. NeuroPace was incorporated in 1997 and is based in Mountain View, California.

Relievant Medsystems, Inc. develops treatment and technologies for chronic back pain. Its Intracept System solution is a minimally invasive procedure that uses radiofrequency energy delivered into the vertebral body of the spine to ablate the basivertebral nerve. Relievant Medsystems was founded by James C. Peacock, Jeffrey Charles Lotz, and Rex Peters in 2004 and is headquartered in Redwood City, CA.

InnoCon Medical ApS is a Danish private company located in Aalborg that manufactures medical devices. The firm was founded in 2017. Jesper Nielsen has been the CEO since the company founding.

Lactocore Group is a privately funded company led by a team of talented scientists and experienced managers whose mission it is to identify and develop transformative new medicines for mental and metabolic diseases. Lactocore’s expertise spans in silico drug discovery, peptide drug development, and behavioral neuroscience.