In biology, adipose tissue, body fat, or simply fat is a loose connective tissue composed mostly of adipocytes. In addition to adipocytes, adipose tissue contains the stromal vascular fraction (SVF) of cells including preadipocytes, fibroblasts, vascular endothelial cells and a variety of immune cells such as adipose tissue macrophages. Adipose tissue is derived from preadipocytes. Its main role is to store energy in the form of lipids, although it also cushions and insulates the body. Far from being hormonally inert, adipose tissue has, in recent years, been recognized as a major endocrine organ, as it produces hormones such as leptin, estrogen, resistin, and cytokine (especially TNFα). The two types of adipose tissue are white adipose tissue (WAT), which stores energy, and brown adipose tissue (BAT), which generates body heat. The formation of adipose tissue appears to be controlled in part by the adipose gene. Adipose tissue – more specifically brown adipose tissue – was first identified by the Swiss naturalist Conrad Gessner in 1551.
LifeCell develops and markets tissue repair products for use in reconstructive, urogynecologic, and orthopedic surgical procedures. Its products include reconstructive and regenerative tissue matrixes, such as Strattice and AlloDerm for plastic, reconstructive, general surgical, burn, and periodontal procedures; Cymetra for injection; Repliform for urogynecologic surgical procedures; GraftJacket for orthopedic surgical procedures; and AlloCraft DBM for bone grafting procedures. Its products are used in applications, such as abdominal wall reconstruction, hernia repair, breast reconstruction, breast plastic surgery, grafting, and ENT/head and neck plastic reconstruction. It offers its products to patients and healthcare professionals through distributors in the United States and internationally.
The company was founded in 1986 and is headquartered in Branchburg, New Jersey. As of May 27, 2008, LifeCell Corporation operates as a subsidiary of Kinetic Concepts Inc.
Hernia repair
Breast reconstruction
Software development
Medicine
Pharmacy and Therapeutics
Orthopedic Surgical Procedure
Periodontal Procedure
Abdominal wall
Bone grafting
Grafting
Plastic surgery
Soft tissue repair
Abdominal surgery
Lumpectomy
Abdominal aortic aneurysm
Reconstructive surgery
Cardiovascular Surgical Procedure
Neurosurgery
Skin repair
Chronic wound
Cytori Therapeutics, Inc.
Cytori Therapeutics, Inc. is an American private company located in San Diego, CA, that engages in development of treatment and devices for cell therapy.
The General Hospital Corp.
http://www.massgeneral.org
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Massachusetts General Hospital was established to provide care to Boston's sick, regardless of socioeconomic status—an innovative idea in 1811. In the words of their founder, John Warren, MD, “When in distress, every man becomes their neighbor.” They subsequently became the first teaching hospital for Harvard University’s new medical school and have been redefining excellence in healthcare ever since. They have remained at the forefront of medicine by fostering a culture of collaboration, pushing the boundaries of medical research, educating the brightest medical minds and maintaining an unwavering commitment to the diverse community they were created to serve.
They believe that because of diversity they excel, through inclusion they respect their community, and with a keen focus on equity they serve, heal, educate and innovate at the highest levels. Their first priority is the well-being of their patients—near and far. As a team they are able to maintain a singular focus on providing the highest quality, most compassionate care to each and every patient.
Vascular Medicine
Digestive disorder
Subspecialty
Heart disease
Surgery
Part of Pluri, Inc., Pluristem Ltd. is a company headquartered in Haifa, Israel, that provides research and development services in the biotechnology field, especially in stem cell research. The firm was founded by Yoram Nathan Drucker. Pluri, Inc. acquired Pluristem Ltd. on June 23, 2003.
Eli Lilly engages in the discovery, development, manufacture, and sale of products in the pharmaceutical products business segment. The company manufactures and distributes products through owned or leased facilities in the United States, Puerto Rico, and 25 other countries. Its products are sold in approximately 135 countries. It also conducts research to find products to treat diseases in animals and to increase the efficiency of animal food production.
Medicine
Humalog Mix
Major depressive disorder
Breast cancer
Insulin
Clinical trial
Oncology drugs
Insulin pen
Idiopathic short stature
Insulin aspart
Generalized anxiety disorder
Bipolar I disorder
Peripheral neuropathic pain
Bulimia nervosa
Panic disorder
Growth hormone deficiency
Endocrinology
Fibromyalgia
Monoclonal antibody
Regents of the University of California
The University of California is the nation's best public university system, delivering top-notch research and innovation to California (and the world).
Pathology
Companion diagnostic
Syneron Medical Ltd. engages in the development and manufacture of aesthetic products, services, and systems. Its products include Nordlys, Gentle Pro Series, PicoWay, Vbeam Prima, and Profound. The company was founded by Shimon Eckhouse and Moshe Mizrahy in 2000 and is headquartered in Yokneam Illit, Israel.
Lorem Vascular Pte Ltd.
http://www.loremvascular.com
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Centre National De La Recherche Scientif
UltraShape Ltd.
http://www.ultrashape.com
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UltraShape redefines aesthetic medicine by developing, manufacturing and marketing innovative non-invasive technologies for fat cell destruction and body sculpting. The company develops and markets clinically proven safe and effective solutions that enhance the lives of patients. The UltraShape proprietary technology employs pulsed (non-thermal) focused ultrasound that instantly, selectively and permanently destroys fat cells without affecting surrounding structures. Founded in 2000, UltraShape has sold Contour I devices in more than 50 countries, demonstrating safety and efficacy.\nThe UltraShape Contour I system, is authorized for marketing outside the U.S. It is the first clinically proven non-invasive solution that offers measurable lasting body sculpting results for men and women with no need for maintenance treatments. The UltraShape system has been shown to be safe and effective in a multi-center controlled trial and numerous other peer-reviewed published independent clinical studies.\nThe device is designed to produce mechanical, non-thermal, acoustic effects which target and selectively destroy (breakdown) fat cells, leaving surrounding critical structures such as skin, blood vessels, nerves, and connective tissue intact. The latest Contour I V3 system uses Vertical Dynamic Focus (VDF) pulsed (non-thermal) focused ultrasound that instantly and permanently destroys fat cells providing patients a convenient noninvasive no-downtime solution to reduce localized fat deposits and body circumference. The UltraShape procedure is based on a natural fat clearance process where triglycerides and cell debris from the destroyed fat cells are processed by the body's natural physiological and metabolic pathways. These pathways are the same that handle fat during weight loss. Results from UltraShape's peer-reviewed published multi-center controlled clinical trial and other independent clinical studies show that the released triglycerides do not accumulate to a clinically significant extent in the blood or liver.\nOver 200,000 patient treatments have been performed worldwide with the Contour I showing high patient satisfaction while demonstrating safety and efficacy. The UltraShape procedure is guided by proprietary real-time tracking and guidance technology designed to deliver smooth, uniform body contouring results. The software guides the operator through a pres-determined treatment algorithm designed to minimize risk of contour irregularities, a common side effect of invasive and non-invasive procedures. The UltraShape procedure is performed during a convenient, 'walk-in, walk-out' session carried out in an office-based environment; it requires no anesthesia or sedation. After treatment, patients immediately resume their daily routines with no need for maintenance treatments.\nThe UltraShape Contour I received the CE Mark in 2005 and a medical device license from Health Canada in 2007. The Contour I system is not available for sale in the U.S; the Contour Plus system is an investigational product limited by U.S. law to investigational use only.
Medical equipment
Triglyceride
Ultrasound
Pulsed Ultrasound
Ultrasound energy
Critical structure
Metabolic pathway
Connective tissue
Algorithm design
Body contouring
Sedation
Aesthetic medicine
Patient treatment
Blood vessel
Patient satisfaction
Side effect
Weight loss
Zeltiq (pronounced Zel ′teek) Aesthetics, founded in 2005, is a science-based medical device company dedicated to the development of non-invasive procedures for the reduction of unwanted fat tissue. The Zeltiq approach utilizes a patented method called Cryolipolysis™ (the use of precisely controlled cooling to remove fat) that is designed to target only fat cells and not harm the skin or other tissue.
The Zeltiq device is cleared by the FDA in the Unites States for various applications related to skin cooling during dermatologic treatments.
Cryolipolysis
Medical equipment
Body contouring
Breast implant
Dermal Fillers
Plastic surgery
Mesotherapy
Diagnostic Reagent
Injector
Neothetics, Inc.
http://www.neothetics.com
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Neothetics, Inc. operates as a holding company, which provides clinical-stage specialty pharmaceutical and developing therapeutics for the aesthetic. It focuses on localized fat reduction and body contouring. The company products include LIPO-202, is an injectable formulation of the long-acting ß2-adrenergic receptor agonist, salmeterol xinafoate. Neothetics was founded by John D. Dobak in February 2007 and is headquartered in San Diego, CA.
SALMETEROL XINAFOATE
Fat reduction
Body contouring
Botanical drug
Herb
ROKIT Healthcare provides hardware, software, and application support. Their custom fabrication technologies deliver solutions to the design, creation, and applications of three-dimensional systems. They provide suffering patients and humans with a hyper-personalized medical organ regeneration solution. They apply artificial intelligence and 3d bioprinting technology to regenerate the skin and cartilage organs through surgery for patients.
3D printing
Biocompatibility
3D bioprinting
Biocompatible material
Tissue engineering
Allergan, Inc.
https://thespotlyte.com/index.html
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Allergan, Inc. operated as a global healthcare company. It engaged in the development and commercialization of specialty pharmaceutical, medical device ,and over-the-counter products for the ophthalmic, neurological, medical aesthetics, medical dermatology, breast aesthetics, obesity intervention, urological, and other specialty markets. The company was founded by Gavin S. Herbert in 1950 and headquartered in Irvine, CA.
Over-the-counter
Dermatology
Botanical drug
Herb
Medical equipment
Dental Equipment
LipoSonix, Inc.
https://innovationsmedical.com/cosmetic-services/liposonix
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LipoSonix, Inc. develops technology for non-invasive cosmetic surgery applications. Its products are used to remove fat and body sculpting. The company was founded by Steven B. Waite, Thomas D. Weldon, Jens Ulrich Quistgaard, Charles E. Larsen and John Arthur Deedrick in 1999 and is headquartered in Seattle, WA.
Caliway Biopharmaceuticals Co., Ltd.
http://www.caliway.com.tw
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Caliway Biopharmaceuticals Co. Ltd. offers pharmaceutical services. It focuses on medical aesthetics and inflammatory medicine discovery of small-molecule therapeutics to help patients suffering from illness or life threatening diseases. The company was founded in 2012 and is headquartered in New Taipei City, Taiwan.
RBio is superior pharmaceutical production standards (GMP) in the appropriate cell therapy manufacturing facilities were seolrim derived from adipose tissue for stem cell therapy in the world No.1 in technology of rare, incurable diseases and other treatment difficult disease for clinical trials and progress and We are devoting ourselves to commercializing therapeutics.
Pharmacy and Therapeutics
Stem-cell therapy
Stem cell
Incurable diseases
Adipose tissue
Cell therapy
Hematopoietic stem cell transplantation
Cell potency
Cancer stem cell
Mesenchymal stem cell
Progenitor cell
Cord blood
Blood stem cell
Embryonic stem cell
Adult stem cell
Clinical trial
Institut National de la Santé et de la Recherche Médicale
Institut National de la Sant? et de la Recherche M?dicale provides medical services. The firm specializes in biomedical research and public health research. The company is headquartered in Paris, Cedex, France.
Public health
Genomics
Antisense therapy
Epigenomics
Epigenetics
RNA interference
Messenger RNA
microRNA
Precision medicine
Genomic medicine
RNA
Genome
Cell signaling
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